<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19188

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMGSHAGKSELGGGEMHVRCAFASAHISSRVRQVEYCVLRPAEKPGGPDLLAGAARALQAAQMQLHAGLEGENAPCNALKLLEQTWLYAIESTPTFPSAPASLWVFGAHDPLDHAGLRETERGTLTAPQDGLEHSTAQHAYFLRAIENAIADMRTADPHAERGVRCGAGVLLVESTPLRLLEFHAHTTLDTLVVRMDAHSVPWMPLAMQYDPDRPCSAPPVRPGESQLVLLPTLVHATYLDVFPGAISQNTRLADALAPVFAQRAAHDTMRVMVRIPVQHPPAMPMDTMDMGLDTATGTLAVTLLWPAALCLCLPAPPAPKEREPLGALCTLSVAALLRAMHRAPSAPLEAAESVVRSHSPRDEEEDVFQGIGQLTEDDFRFFGEPVDAAAAPPPVQAHAPAASHASPLGSPHETPIFAAPTPRASKYDVHGKLYTPLLSRKRRASGELALERRVVPRISPYMPADTPQVPVHSPLLDASESGSGSEKSEKSDAPALPFVSRAVALVRLQCSTWVAHQGALQARPCSGTRLEWAAHGAPRPIERDQCAPAAWGPLESVCVAVANPVPRFLLGCQRAVVQVCPTALDAWATLGLEPVGGPKRICVCAVLLGDMDPLAVRQWLTGLEHAYVRLRMGTLCASSAVLAWQDGQLVNTANGTPTVLANAWGAKHAADTRAICLLHAPDTASLDAAEHLYKQYRAAPSVHAAHAVLALPRDFVQPAWRQDFRAQARIARVIYDAVPRAGRAIAHTLALAPGYYAACKYLRAECAMQLAWPPPLQNVLQHGAVLHVAYDVVPQDACSMVRVVGIDDRAQCTFVQTWASQGTRADVRRIWEMVRAQMRTAPQVAWNSVVCRFGAMPMAESEAWAVLGTERKRDAALLDTLIACVERGAPLHMPAQEKNTLAAPLHAVFPTERMVLGAKGEQLLALQTAYVAQESTGAWTVHLLHAFFTAQERALDGYMHDLVLHLGALQYLATARWPLEAPLLPWHVAVLAAA
Length994
PositionKinase
OrganismMalassezia vespertilionis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Malasseziomycetes> Malasseziales> Malasseziaceae> Malassezia.
Aromaticity0.06
Grand average of hydropathy0.005
Instability index44.05
Isoelectric point6.48
Molecular weight107104.93
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19188
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.37|      29|      44|     408|     450|       1
---------------------------------------------------------------------------
  337-  376 (40.07/13.22)	LRAMHRAP..SAPleaaesvvrshSPRDEEEDVFQGI............GQLTE
  382-  404 (31.47/ 6.57)	FGEPVDAA..AAP...........PPVQAHAPAASH..................
  408-  450 (39.83/31.41)	LGSPHETPifAAP...........TPRASKYDVHGKLytpllsrkrrasGELAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.89|      27|      45|     816|     842|       3
---------------------------------------------------------------------------
  816-  842 (49.67/34.61)	QTWASQGT..RADVRRIWEMVRAQMRTAP
  862-  890 (41.22/27.29)	EAWAVLGTerKRDAALLDTLIACVERGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     222.25|      53|      53|     688|     740|       6
---------------------------------------------------------------------------
  624-  689 (59.24/24.96)	EHAYVRLRMG.TLCASSAVLAWQDgQLVNtangtPtvlanAWG...AKHAADTRAICLLHapDtASLDAA
  690-  742 (91.84/42.51)	EHLYKQYRAAPSVHAAHAVLALPR.DFVQ.....P.....AWR...QDFRAQARIARVIY..D.AVPRAG
  743-  795 (71.17/31.38)	RAIAHTLALAPGYYAACKYLR.AE.CAMQ.....L.....AWPpplQNVLQHGAVLHVAY..D.VVPQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.24|      25|      48|     165|     189|       7
---------------------------------------------------------------------------
  165-  189 (44.16/27.24)	CGAGVLLVESTPLRLLEFHAHTT.LD
  215-  240 (40.08/23.96)	CSAPPVRPGESQLVLLPTLVHATyLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     113.14|      24|      53|     895|     918|       8
---------------------------------------------------------------------------
  895-  918 (42.06/19.41)	AQEKNTLAAPLHAVFPTERMVLGA
  950-  968 (32.94/13.71)	AQER.ALDGYMHDLV....LHLGA
  973-  993 (38.14/16.96)	ATARWPLEAPL...LPWHVAVLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.72|      29|      33|     563|     592|      10
---------------------------------------------------------------------------
  563-  592 (50.12/29.03)	NPV..PRFLLGCQRAVVQVCPTALDAWATlGL
  593-  623 (49.61/24.92)	EPVggPKRICVCAVLLGDMDPLAVRQWLT.GL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.07|      18|      35|     280|     301|      11
---------------------------------------------------------------------------
  280-  301 (26.06/24.98)	PPAmPMDTMDMGldtATGTLAV
  316-  333 (35.01/18.84)	PPA.PKEREPLG...ALCTLSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19188 with Med13 domain of Kingdom Fungi
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