<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19180

Description Uncharacterized protein
SequenceMTSRTPMGAHPRPPQRSVSSSSLPVQRPPPQRTLSHQQQFVPASPVRKDSSFIDLTADAGDTTPNRYNTTPRRGGSRLRLELSHNASTNSLPTSESPQSLTPSRIPANSDPFQTMVGSPIPINSANSTSMPMPTRRPVASQLRSAPPVTTTTAPALVKKDTRPKPYTVEVPSAAPRYFAANRPETTPRNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLTALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVTGFSEKDWKTRVTYAIRLATNLYSEQLLDRDHYLDWIVSGIENSLQSRIPMWLLIAQIYWKDILRFRKYGRRLVFALLSHLHVIYNDPDQDLLMQLSSRLSTLLSSLVLSNPESFINPGAWPRYKNTLQAFLRTDHEPTQKSLHIINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDDHLAATCWATSENKPLIMKTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDSISIEDKTRKNLIYHLVTELVRTGHFSVSQYMQWTIARGGYHSGAEIDADSGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSIVEEEQDIANAIKFVRHTVGLPLPPGDPLSERKPVSLKKLLPRLSSSSGALRSCIGAHLRDVLTSQFNHNNQPSLPLTMYNSVRAIMEAVEDYSMLSDVLGACSKIADYDVLASVADTVHSNLQIFSALGSANDLFNVLIERLKSMNEEQGIVPRPLLASLSSLAQRMTGYEVIASHLRQELLQSDRSNAVDACSPVSDIVAAPTQHAENELAEDIEKQLSSGTRLDPPTMNKLFRRIIPALERGWEKTDDTRRVFATLLTRIRVFDAHHFDKLMTDWTSHVRSLSNRSPLVSLFPLLVSTGCLTMPIVMSTASPPSASFQNLSSDPSGNKFGPATYLQELLQLIIMPLPSGTGLYAEEGYRFHTEQKCAKFEQSKGLLNLVRNALLEYSGLRNHANSPEFPLDNPTCQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPNANEGQDQGSSRFEIFAKAMDRAIEAGNIMWTSLLPCLSDDITQHLKSQAQSVFLELIPSSKAPECADTGSRQSLRMAENLLEVVEAIISGQPPPKVAQLSSGMVEKLTDLWEIIATGPHERPNCYAAVLQHWLPAMLRFVTLHSLSSEPPSAPLPTASATRPPIPPVHDTRARIILVLCGLLLEIDTLSPAIVGSLPQQVFDIAILLVDALPEDLRANCAKAILLTSGGLPNQGTSSDPRLYYLFSSPPPSVADNIMLSHREKAATPQSAVARGMGAQYGIGPAVQERLTPFVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1532
PositionKinase
OrganismFusarium venenatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.234
Instability index50.27
Isoelectric point8.83
Molecular weight168930.10
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP19180
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     215.58|      69|      97|     802|     875|       1
---------------------------------------------------------------------------
  802-  875 (104.09/72.93)	EAVEDYSMLSDVLGACSKIADYDvlasVADTVHSNLQIFSALG..SANDLFNVLIERLKSMNEEQGiVPRPLLASL
  903-  973 (111.50/66.10)	NAVDACSPVSDIVAAPTQHAENE....LAEDIEKQLSSGTRLDppTMNKLFRRIIPALERGWEKTD.DTRRVFATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.16|      32|      96|    1325|    1358|       2
---------------------------------------------------------------------------
 1325- 1358 (59.35/41.66)	PHE.RPNCYAAVL..QHWLPAM.....LRFVTLhsLSSEPPS
 1419- 1458 (47.81/26.75)	PEDlRANCAKAILltSGGLPNQgtssdPRLYYL..FSSPPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.18|      25|      96|      43|      67|       3
---------------------------------------------------------------------------
   43-   67 (44.73/25.33)	ASPVRKDSSFIDLTADA...GDTTPNRY
  139-  166 (40.45/22.16)	ASQLRSAPPVTTTTAPAlvkKDTRPKPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.23|      23|      95|       2|      30|       6
---------------------------------------------------------------------------
    4-   27 (38.37/22.89)	RTPMGAhPRPPQRSVSSS.SLPVQR
  113-  136 (35.86/12.86)	QTMVGS.PIPINSANSTSmPMPTRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     181.35|      46|     253|     743|     788|       7
---------------------------------------------------------------------------
  743-  781 (52.21/27.89)	.................................LSERKPVSLK..KLLPRLSS....SSGALRSCIGAHLRDVLTSQF
  999- 1034 (48.86/25.58)	.................................LSNRSP..LV..SLFP.LLV....STGCLTMPIVMSTASPPSASF
 1036- 1107 (42.61/21.28)	NLSSDPSgnkfgpatylqellqliimplpsgtgLYAEEGYRFHteQKCAKFEQ....SKGLLNLVRNALLE..YSGLR
 1108- 1146 (37.67/17.87)	NHANSPE..........................FPLDNPTCQE..SLLETLRTlvlvDSSAVSNALG...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.29|      19|     427|     723|     741|       9
---------------------------------------------------------------------------
  723-  741 (35.48/20.90)	ANAIKFVRHTVGLPLPPGD
 1152- 1170 (31.80/17.97)	AEAVGLVRKVTTKLLIPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.03|      34|      99|    1270|    1306|      10
---------------------------------------------------------------------------
 1270- 1303 (59.84/46.24)	PECADTGSRQSLRMAENLLEV..VEAIISGQPPPKV
 1372- 1407 (54.19/32.94)	PPVHDTRARIILVLCGLLLEIdtLSPAIVGSLPQQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.81|      28|      47|     533|     560|      12
---------------------------------------------------------------------------
  533-  560 (44.47/24.71)	SRNSRLVVSSTASPPAG..RSQLVKLLDAA
  577-  606 (42.34/23.16)	SENKPLIMKTVVEWATSfhRPGLAKVYAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.62|      14|     253|      28|      41|      17
---------------------------------------------------------------------------
   28-   41 (27.77/16.06)	PPPQRTLSHQQQFV
  282-  295 (25.85/14.38)	PPPRVTLTDTKREV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.54|      35|     305|    1184|    1222|      25
---------------------------------------------------------------------------
 1184- 1222 (49.32/42.61)	IANELTlPFCQLKLNLdLSLPQPNAneGQDQGSSRFEIF
 1492- 1526 (62.22/37.01)	VQERLT.PFVLRRWEV.LSEPTPNV..GENDTSLSLGLF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19180 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MTSRTPMGAHPRPPQRSVSSSSLPVQRPPPQRTLSHQQQFVPASPVRKDSSFIDLTADAGDTTPNRYNTTPRRGGSRLRLELSHNASTNSLPTSESPQSLTPSRIPANSDPFQTMVGSPIPINSANSTSMPMPTRRPVASQLRSAPPVTTTTAPALVKKDTRPKPYTVEVPSAAPRYFAANRPETTPRNPVDPF
1
194










Molecular Recognition Features






MoRF SequenceStartStop




NANANA