<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19175

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDTYIDGRFERLEKALANLIDSVTKFHPSIQQGDELDAADKELSNGLGEVQTHQNNYLRIQQLRESSAALDTQIRETLSNLATTRKDIVTTHTTTFPAGPSYAIAYEELLNYARRISKTTMPPAGTIKAIPATAAPPTPDGQTPGAQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSTMSANTSLPNEWTQFLNPLTDQIFVPWPNDLQLGAGALAAHQVLLEQGINPKGYDPAEEEERKRREEEERKKKEEEDRIAQEEREKKIREERERQRIERERQREKDQEAWRRASLVGGPTAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD
Length343
PositionMiddle
OrganismFusarium venenatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.05
Grand average of hydropathy-1.009
Instability index52.95
Isoelectric point4.80
Molecular weight38232.52
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19175
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.12|      12|      15|     255|     269|       1
---------------------------------------------------------------------------
  255-  266 (21.40/14.63)	REEEERKKKEEE
  279-  290 (21.72/ 6.86)	REERERQRIERE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.06|      24|      28|      13|      40|       2
---------------------------------------------------------------------------
   15-   39 (36.75/29.41)	ALANLIDSVtKFHPS....IQQGDELDAA
   42-   69 (35.31/13.20)	ELSNGLGEV.QTHQNnylrIQQLRESSAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.16|      25|      27|     130|     154|       3
---------------------------------------------------------------------------
  130-  154 (47.13/27.55)	IPATAAPPTPDGQTPGAQTPGPD.SQ
  158-  183 (41.03/22.94)	VMTPSAPPSSQVQSPAVMNGTPHvSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.46|      19|      28|      76|      99|       4
---------------------------------------------------------------------------
   76-   99 (24.86/34.42)	ETLSNLAttRKdivTTHTTTFPAG
  107-  125 (35.60/26.87)	EELLNYA..RR...ISKTTMPPAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19175 with Med4 domain of Kingdom Fungi
Unable to open file!