Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDGRFERLEKALANLIDSVTKFHPSIQQGDELDAADKELSNGLGEVQTHQNNYLRIQQLRESSAALDTQIRETLSNLATTRKDIVTTHTTTFPAGPSYAIAYEELLNYARRISKTTMPPAGTIKAIPATAAPPTPDGQTPGAQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSTMSANTSLPNEWTQFLNPLTDQIFVPWPNDLQLGAGALAAHQVLLEQGINPKGYDPAEEEERKRREEEERKKKEEEDRIAQEEREKKIREERERQRIERERQREKDQEAWRRASLVGGPTAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 343 |
Position | Middle |
Organism | Fusarium venenatum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.009 |
Instability index | 52.95 |
Isoelectric point | 4.80 |
Molecular weight | 38232.52 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP19175 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.12| 12| 15| 255| 269| 1 --------------------------------------------------------------------------- 255- 266 (21.40/14.63) REEEERKKKEEE 279- 290 (21.72/ 6.86) REERERQRIERE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.06| 24| 28| 13| 40| 2 --------------------------------------------------------------------------- 15- 39 (36.75/29.41) ALANLIDSVtKFHPS....IQQGDELDAA 42- 69 (35.31/13.20) ELSNGLGEV.QTHQNnylrIQQLRESSAA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 88.16| 25| 27| 130| 154| 3 --------------------------------------------------------------------------- 130- 154 (47.13/27.55) IPATAAPPTPDGQTPGAQTPGPD.SQ 158- 183 (41.03/22.94) VMTPSAPPSSQVQSPAVMNGTPHvSQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.46| 19| 28| 76| 99| 4 --------------------------------------------------------------------------- 76- 99 (24.86/34.42) ETLSNLAttRKdivTTHTTTFPAG 107- 125 (35.60/26.87) EELLNYA..RR...ISKTTMPPAG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EAWRRASLVGGPT 2) PPQQKAQFQFTNLDDLDDD | 298 321 | 310 339 |
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