<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19173

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAMNGNSTIPNGEADDASSENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSQLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEEIQWMSDVNTQLSLRLNLEDFDKIPYPFRNYEIDSGRVTFTVPGEFEVDLTIADEDFEKQFWFIDFRFAFRPAASSIPEGLKNYLESHVNDILSKDGLLGCYQFLHELVLTHKLNELKRQANQMSRGSWTGTLKVEPLNRALAIQYWTSRAQPGSPKSWVSVAVTSGKKANGQLDPKLSSHLTAKWYRDNKEVKGENITFDADNLSAEALMKTVIGRHIDFLLGSVHSKLLSFPRFQNRQAAMVLRSSQDDPAASSLTMRVGFKDSATLLIEPTTGVFAVKPHSKFTWSPENQLNNGKNPAEDGAACLENVRCAVMEDELSRRGSTTGWSIKRSPLNKDELRSLTNTREWTKTIWLHRAGWEANWFVMVLLSPSGDVWWLVDVNRNASGQAPRLASKLPLNKGYPRLDDEFWNNLTLFASGMIAQAVDQRELHKQNIKFKPHGANNWSLPQQVRLPTLEIALSGIFPSMVFDNAEKDNPKTAGATESGKFGSTVRAASASGISTKQPWANDIVSVRFKGVQPAETESTSPESAKPGDDKSDIPFACVSDAIIKVRRPAKFAMLKSHMVGRDVSWNARTGEFCLRMRSSIGQSMLESLKARVKAVDRFVSFFESMDKAKESIVAESVSLKEVTFSYGPLASEVSNKDQPSRLWRITLNLSQNDIDLVMGETNPHLPVTNLMQKLVNGANGIGALMNWLPGSLPALEAVKKIRETWRDVESRHQGRFRFMMDSVDEMSIQYSVTGTGPGNHPIHCDITFLAHIKHRRGEPWWHIMRKPLNGASVSNDEFSKALKPVWEATGEKWTGLVTGAAGRPHDGIASLLLAIDEAIRPLAGSSFPNNSEVVVLE
Length1019
PositionTail
OrganismFusarium venenatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.08
Grand average of hydropathy-0.349
Instability index37.73
Isoelectric point7.71
Molecular weight113507.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19173
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.02|      32|      49|     646|     680|       1
---------------------------------------------------------------------------
  646-  680 (47.89/36.14)	NAEKDNPKTAgatESGKFGSTVRAASASG..ISTKQP
  697-  730 (51.14/30.66)	ETESTSPESA...KPGDDKSDIPFACVSDaiIKVRRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.85|      24|     373|     169|     200|       3
---------------------------------------------------------------------------
  153-  162 ( 9.56/ 6.04)	GEAAWMPDLS.........................
  173-  200 (39.75/27.79)	EEIQWMSDVNTQLS...LRLNledfDKIP....YP
  548-  578 (35.54/14.72)	GDVWWLVDVNRNASgqaPRLA....SKLPlnkgYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.41|      14|     193|     295|     315|       6
---------------------------------------------------------------------------
  295-  314 (13.72/25.34)	NqmSRgSWTGTLKvepLNRA
  519-  532 (28.68/11.62)	N..TR.EWTKTIW...LHRA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.52|       9|     192|      46|      59|       9
---------------------------------------------------------------------------
   46-   59 (12.95/17.52)	PAAamngnSTIPNG
  245-  253 (18.57/ 8.77)	PAA.....SSIPEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19173 with Med14 domain of Kingdom Fungi
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