<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19169

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASIAFRIYEPSIDQSHSFQSSALEIQSTLRDQGKLVSYDTDRGAIWIFQITNKDGASKAVSFGSGVSLEACGYTLGMVEEGTLEPAALQKNRIPGNTTQNAATNTAAITSPAEPHQRNPLISPTQTVGTQAEGGVQLPAQPVDTKTTQPVPKIIYEQFIIAVISAITFAFCSQSMAVPLNYRTILIPPLQADRNEHEKDSLQADPVIGTFKTYLTTTGSLVVSLYFSYCQNLATVEDVLSGDSTSSSGPILAAPYGVFATKSSFSNGDADRSLVQTPNTQALSVRSFPDANDSLWKHSCLKALEYCGLNPSNFKAGSWVNLLIMKPTSQDVDGEQKRLRATVPWPGALCFRKKLLEVSTTHRVGNTMLSGHEECHDPLGDARGWFAGTSEREERVSRRKAERAHTAAKEVNVANLQAQSLNGQSPLSVRRPSTAAAGVMYPTPPDAIQQHLGVTPSIDGATSSPNNHHPTLAVVDADATMPTVTLMADVDHDTWDGGHEQKRERSDSNLLGDTDDIMNGMGGDVFGDHDVTEDDFNFFDGPDGNDMDIDIADLQPISHPPPPQAIPPPAIPPQTILPQAILTPAMPPQAMPPPMITQPQPQKVIEPKPNIKSKPKTHEPVFAKPELKHARSSLNDEINHKVKTERSNSNKRGSSPFDPDTVFKRVKASLASPTQENFTFQAPLRRKSSIFEKVEFDPKIPLINKKYEHGGAFDFSKDQGSGELKRDTEGLSRDEYLERQGKIKPDSKTLSGVSLIRSLTGVDGSANYTNAQKSNGNASFSEDSDVDSEADDLSSISGGPMSPIKSSVKRTVVDDDALSQATTSREADLIDDATEEQFAIELPKLSKTESPELPLHRFFSDPEPLNAEVGLSNLEFVEVAQIVTEQAATGRLDIGIDHRKESAALATMKGHELNVARSSLQLLHNIIPSNLGSAMAVRLKGLLEILDLPLVGQPNRMQPRPIPGRDTNVEQLRANNLYQIPVPHLEVRRSETKLSVLPSSISFWEGLGLSPSWGAKDVTALCIFPGWKGMPDHVGSFLSRSKSVYESLKLGTFNNLPLSGDWDDGILPYEVDRISTSPDATVTGHGSSLVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSELLAARKESPQNELVLQLVSSNLISSTTSLVVPTPAEMIKLCVETYDRCTLFLAPEYGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCIHVGYAESLDGRWITAAWTDNRGQRQATASYSITRSRTPDRSASQHKAAIITEIWATTLSMISIWKVQWRVIITRAGPMDQKEVEWWQAASTLDDKYSFTMILMSVDTSPSLQLVPPVVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRENTLAATPGAESVTEPDADSFLIDATDQTWGAIAAHRFGNSTTLLEVRPALASGYLIKRTGIKIEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVTDREMDVRPWHIAVAEKGVRALHLLL
Length1537
PositionKinase
OrganismFusarium venenatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.354
Instability index46.41
Isoelectric point5.29
Molecular weight167765.97
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19169
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.28|      37|     254|    1202|    1277|       1
---------------------------------------------------------------------------
  597-  634 (70.17/21.25)	LTPAM.PPQAMPPPMITQPqPQKVIEPK.PNIKSKPKTHE
 1207- 1245 (59.11/81.78)	LAPEYgGPTPAPAVMLEQP.PPRMIDFKlTTSPSQSLMHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     298.43|      97|     190|    1077|    1189|       2
---------------------------------------------------------------------------
 1077- 1179 (146.14/101.33)	WDD......GILPYEVDRiSTSPDATVTGHGSSLVesMEVLRSSLSELKS.KDKNLVIYFVYSPDNPASiIEACTAFYRCFDEYS..ELLAARKESPQNELVLQLVssNLIS
 1266- 1371 (152.29/87.05)	WTDnrgqrqATASYSITR.SRTPDRSASQHKAAII..TEIWATTLSMISIwKVQWRVIITRAGPMDQKE.VEWWQAASTLDDKYSftMILMSVDTSPSLQLVPPVV..KIPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     293.10|      87|     115|     316|     410|       3
---------------------------------------------------------------------------
  316-  410 (145.69/103.29)	LKALEYCGLNPSNFKAGSWVNLLIMKPTSQdvDGEQKRLRATVPWPGALCF...RKKLLEVSTTHRVGNTMLSGHEECHDPlgdargWFAGTSEREER
  431-  520 (147.41/87.53)	LQAQSLNGQSPLSVRRPSTAAAGVMYPTPP..DAIQQHLGVTPSIDGATSSpnnHHPTLAVVDADATMPTVTLMADVDHDT......WDGGHEQKRER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.38|      11|      21|     737|     747|       4
---------------------------------------------------------------------------
  737-  747 (19.06/10.11)	GELKRDTEGLS
  756-  766 (19.32/10.34)	GKIKPDSKTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.02|      25|     116|     787|     846|       5
---------------------------------------------------------------------------
  542-  576 (40.05/ 7.21)	GDHDVTEDdfnffdgpdgNDMDIDIADLQPISHPP
  791-  815 (43.97/55.70)	GNASFSED..........SDVDSEADDLSSISGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.53|      10|      15|     670|     679|       8
---------------------------------------------------------------------------
  670-  679 (18.91/12.77)	SPFDPDTVFK
  687-  696 (18.62/12.42)	SPTQENFTFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.58|      28|     867|     100|     127|      11
---------------------------------------------------------------------------
  100-  127 (48.86/32.58)	EPAALQKNRIPG...NTTQNAATNTAAITSP
  968-  998 (48.72/32.46)	QPNRMQPRPIPGrdtNVEQLRANNLYQIPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.97|      15|      15|     816|     830|      12
---------------------------------------------------------------------------
  816-  830 (24.51/13.70)	MSPIKSSVKRTVVDD
  833-  847 (23.46/12.83)	LSQATTSREADLIDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19169 with Med13 domain of Kingdom Fungi
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