<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19168

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMYFKKPLCKAIVLWTRFRASLSILDSFRDTDYHPLPPLDDRYRASFAMENPAAAGDAMRTAIEYWCQFVARCVSERLETDKFEAYVKIVHDQHPLPPTLVADFFLRPQPSDDSSLDPRIPPYLQVLTKLGYVDTPSILRALYKYSSSHAHAQAQKEHLQLNTEEGKGKEKEKQKENGDDKEKVEEKGDAQPKKNIIRWKSSYWAEEVLFYRLTKSVVEGRAIQDSRTALEVAMIISKFMELFTTALPATAFAADMLEQQFPSGQLRDEMESSRAALVALLLRLCENNILVSAIGKPFAKDVRKALSTSLASFLPALQLVPEIADKLELFRTEILASSDPADKKKQVANAAMDELLDSTVGLENFVVAPISVSNTRAGLYIYLNAALIGRPILDDHALFSYMSNKYGADIQSSAIDLILASFDILANAVFRNEGQKDAHLLRSFLINKLPLLLYQLLPPGFSGTSAEFCITEALTHVDTSLFPTASLMFDESRNNNPYTESIREEFCAACVLHGLVQREHVERILGEISLSYEPSLQKHSKDKLVQDCLSDIDKIQGLVRELDKTDGNVGAVCQALVEVLRQSCHNKETMSLKLLCSQLAAKPQSLDVILLFEKLPNILEPLCQLLDNWRYEEDQGEYQPVYEEFGAVLLLVFAFTYRYNLNAVEIGITAPDSWVARIIGRGHIGRQGDELTQRENDHINGWVHGLFDTEAGGLGDELMSSCPPQEFYLIVAPLFQSIVVAYTYGYLNDESLKGGIEYLVDTFLLPSLVPAIRFLADYLWIDQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHALRTYQRRDPKNQDIEPLLRTLQESIPLSRRTGGTDLNELESWTATPPSGLSSAVKLTIQGLVHWSIHPAMNSMPTSYTHRQILAGLKILGPRRLLHVILEEVRQHTAAGSANIIYDVAMSLICAPDAVKDTPVTGMLDANGNMLPPIQRQRTLRDLLKVEVEGCRKLQKEDPVLAEHVVRLLRRVEAQMIVPQPQGMLQPADMTLNLTDDTAALGDAMAAAASGVQGDNMSVDNLALDVSMGGVSSDMGLGSATDGGNLDPSGDAAMFEGFDTQDMDNFNWDITDTF
Length1110
PositionTail
OrganismFusarium venenatum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.07
Grand average of hydropathy-0.141
Instability index43.30
Isoelectric point5.07
Molecular weight123455.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19168
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.57|      30|      30|     736|     765|       1
---------------------------------------------------------------------------
  727-  743 (18.65/ 7.99)	..............YLIVAPLFQSIVVAYTY
  744-  773 (51.35/35.35)	GYL.NDESLKGGIEYLVDTFLLPSLVPAIRF
  776-  798 (22.57/11.27)	DYLwIDQKEQKSIIKILQLILLP........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.29|      40|     148|     520|     569|       2
---------------------------------------------------------------------------
  520-  569 (55.17/57.44)	VERILGEISLSyepslqkHSKDKLVQdclSDIDKIQGLVREL.DKTDGNVG
  674-  714 (69.12/43.95)	VARIIGRGHIG.......RQGDELTQ...RENDHINGWVHGLfDTEAGGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.85|      37|      59|      31|      71|       3
---------------------------------------------------------------------------
   31-   71 (61.70/48.41)	DYHPLPPlddRYRASFAMEnPAAAGD.AMRTAIEYWCQFVAR
   91-  128 (65.15/38.72)	DQHPLPP...TLVADFFLR.PQPSDDsSLDPRIPPYLQVLTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     255.50|      70|     151|     808|     881|       4
---------------------------------------------------------------------------
  808-  881 (102.99/80.02)	MLSSVKNLIAkPLEHAlRTYqrRDPKNQDIEPLLRTLQESIP........LSRRTGGTDLNELESWTATP.PSGLSSAVKLTI
  897-  944 (61.01/34.55)	........................PTSYTHRQILAGLK..IL........GPRRLLHVILEEVRQHTAAG.SANIIYDVAMSL
  959- 1028 (91.50/57.35)	MLDANGNMLP.PIQRQ.RTL..RDLLKVEVEG.CRKLQKEDPvlaehvvrLLRR........VEAQMIVPqPQGMLQPADMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.84|      29|     152|     428|     457|       5
---------------------------------------------------------------------------
  428-  457 (47.40/39.54)	VFR....NEGQKDAHLLRSFLINKlP.....LLLYQLLP
  578-  615 (38.44/26.23)	VLRqschNKETMSLKLLCSQLAAK.PqsldvILLFEKLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19168 with Med5 domain of Kingdom Fungi
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