Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSFHPQTPQSPSQFSSGTSEPVLSVATSMTTTTTPTTLPTPAHSVTGSAHHDLAMADDSPHKRKRSMDDSGDRDQKKFHVEESKLGIEDLHLDVGKKYLLCQTPHPETLPRVSEDLYDLFNLNELAAEVAREKPNGEKNALRSSYTGHMKRLGIAGHWKVQRTDKDSNEKPDFFDILHMPDEDWDNTIVKGQNIKHGLSQASLSALGRSVTMAKGPLGKKDWDISVLGLQSPGGDSKLPSSARPTAPNTPLNIPGAVGRLKAQGSSSNDPNRPKRNVKKRTYGDSSFEGYGEGYPDDDTAMEGGYSTGEGEGGQKRRKKNPGNASPYPSAMRQQSYGPGMVGA |
Length | 343 |
Position | Head |
Organism | Fusarium venenatum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.918 |
Instability index | 50.06 |
Isoelectric point | 7.22 |
Molecular weight | 37194.81 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP19164 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 100.36| 31| 35| 183| 217| 1 --------------------------------------------------------------------------- 183- 217 (42.54/32.47) DWDNTIVkGQNIKHGLSQASLSAlgRSvTMAKGPL 221- 251 (57.82/29.32) DWDISVL.GLQSPGGDSKLPSSA..RP.TAPNTPL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.76| 20| 214| 47| 70| 2 --------------------------------------------------------------------------- 47- 70 (33.00/25.13) GSAHHDlamaDDSPHK..RKRSMDDS 264- 285 (32.76/16.43) GSSSND....PNRPKRnvKKRTYGDS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FDILH 2) GQKRRKKNPGNASPYPSAMRQQ 3) SFEGYGEGYP | 174 313 286 | 178 334 295 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab