<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19145

Description Mediator of RNA polymerase II transcription subunit 13
SequenceHSVSFVSTGVHICFLISDMADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLAEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQKKRKYSASSGGLCEEETAAKVASWDFVEATQRTNCSCLRHKNLKPRNAGQQGQAPTLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVAMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFPPQFPEAVEPTVYVGTAVNLEEDEASIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKVSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSGVGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQFLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSTEHINGGLRESEKLPDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVASTSQSLITPSQMANTGNANTPSATLASAASTTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQGTDRLLSTEAHEEVPNILQQPLALGYFVSTAKAGPLPNWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2171
PositionMiddle
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.08
Grand average of hydropathy-0.382
Instability index52.29
Isoelectric point5.49
Molecular weight239142.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19145
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.86|      39|      39|     971|    1009|       1
---------------------------------------------------------------------------
  514-  552 (43.58/18.12)	.AKTPQMH.GTEMANSPQPPPLSphpcdvvDEGVTKTP.STP.....
  971- 1009 (77.86/39.02)	PAYTPQTHTSFGMPPSSAPPSNS.......GAGILPSP.STPRFPTP
 1012- 1050 (65.42/31.44)	P.RTPRTPRGAGGPASAQGSVKY.......ENSDLYSPaSTPSTCRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.83|      34|      40|      27|      66|       2
---------------------------------------------------------------------------
   33-   66 (60.76/47.97)	QGPTSAPILFPVTEEDPILSSF.SRCLKADVLGVW
   70-  104 (62.07/32.97)	QRPGRRELWIFWWGEDPNFADLiHHDLAEEEDGVW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.60|      36|      40|     865|     903|       3
---------------------------------------------------------------------------
  865-  903 (57.59/44.03)	VLEGNSsgVGAQFKiEVDEGFCSP.K.PSE.IKDFSY.VYKPE
  907-  946 (51.01/28.56)	ILVGCS..MFAPLK.TLPSQFLPPiKlPEEcIYRQSWtVGKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.95|      22|      37|    1249|    1270|       4
---------------------------------------------------------------------------
 1249- 1270 (39.20/21.22)	DEALVKSSCLHPWSKRNDVSMQ
 1287- 1308 (40.75/22.35)	QDAIQKKRTVRPWGVQGPLTWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.17|      26|      45|     332|     357|       5
---------------------------------------------------------------------------
  332-  357 (46.31/28.48)	QTVDPQSAQKWVKFSSVSDGFNSDST
  378-  403 (46.86/28.92)	QECNMNRAQKKRKYSASSGGLCEEET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.79|      42|      46|    1513|    1556|       6
---------------------------------------------------------------------------
 1513- 1556 (62.00/41.81)	MTSGVAisTSVATANSTLTTASTSSSSSSNLNS.GVS..SNKLPSFP
 1561- 1605 (59.80/34.45)	MNSNAA..GSMSTQANTVQSGQLGGQQPSALQTaGISgeSSSLPIQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.96|      33|      39|    1110|    1146|      10
---------------------------------------------------------------------------
 1110- 1146 (52.19/49.78)	DPTQEVQYRctcgFSAVMNRKFGN.NSGLFLEDEL..DII
 1151- 1186 (46.78/31.51)	DCGKEAEKR....FEALRATSTEHiNGGLRESEKLpdDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.67|      16|      40|     225|     241|      11
---------------------------------------------------------------------------
  225-  241 (26.59/22.65)	ATKKLIGEWKQFYPiSC
  263-  278 (28.08/18.35)	AVEVLVAGVRMIYP.AC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.06|      30|      41|     134|     165|      17
---------------------------------------------------------------------------
  134-  165 (49.51/41.95)	VRIGKWfvKP.YEKDEKPINKSEHLSCSFTFFL
  175-  205 (46.56/31.80)	VEINQH..QPvYLLSEEHITLAQQSNSPFQVIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19145 with Med13 domain of Kingdom Metazoa
Unable to open file!