<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19144

Description Mediator of RNA polymerase II transcription subunit 13
SequenceYKIFFCPNLHSISLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLAEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQKKRKYSASSGGLCEEETAAKVASWDFVEATQRTNCSCLRHKNLKPRNAGQQGQAPTLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVAMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFPPQFPEAVEPTVYVGTAVNLEEDEASIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKVSCKESKTGNLDPLSSPHSLYLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSGVGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQFLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSTEHINGGLRESEKLPDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVASTSQSLITPSQMANTGNANTPSATLASAASTTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQGTDRLLSTEAHEEVPNILQQPLALGYFVSTAKAGPLPNWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2166
PositionMiddle
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.08
Grand average of hydropathy-0.392
Instability index52.40
Isoelectric point5.54
Molecular weight238839.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19144
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.74|      31|      40|       7|      46|       1
---------------------------------------------------------------------------
   11-   44 (48.58/45.47)	SIS...LADLTGIkWKRYvwQGPTSAPILFPVTEEDP
   48-   81 (58.17/25.51)	SFSrclKADVLGV.WRRD..QRPGRRELWIFWWGEDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.86|      39|      39|     966|    1004|       2
---------------------------------------------------------------------------
  509-  547 (43.58/14.73)	.AKTPQMH.GTEMANSPQPPPLSphpcdvvDEGVTKTP.STP.....
  966- 1004 (77.86/31.90)	PAYTPQTHTSFGMPPSSAPPSNS.......GAGILPSP.STPRFPTP
 1007- 1045 (65.42/25.67)	P.RTPRTPRGAGGPASAQGSVKY.......ENSDLYSPaSTPSTCRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.60|      36|      40|     860|     898|       3
---------------------------------------------------------------------------
  860-  898 (57.59/39.49)	VLEGNSsgVGAQFKiEVDEGFCSP.K.PSE.IKDFSY.VYKPE
  902-  941 (51.01/25.61)	ILVGCS..MFAPLK.TLPSQFLPPiKlPEEcIYRQSWtVGKLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      26|      37|     696|     732|       4
---------------------------------------------------------------------------
  696-  725 (36.84/42.44)	DEEFLF.PDKKdrQNSEREAgkKHKVEDGTS
  735-  761 (44.07/20.24)	DAMSLFsPSIK..QDAPRPA..SHARPPSTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.17|      26|      43|     327|     352|       5
---------------------------------------------------------------------------
  327-  352 (46.31/34.16)	QTVDPQSAQKWVKFSSVSDGFNSDST
  373-  398 (46.86/34.68)	QECNMNRAQKKRKYSASSGGLCEEET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.95|      22|      37|    1244|    1265|       6
---------------------------------------------------------------------------
 1244- 1265 (39.20/21.84)	DEALVKSSCLHPWSKRNDVSMQ
 1282- 1303 (40.75/23.00)	QDAIQKKRTVRPWGVQGPLTWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.76|      50|      56|    1487|    1536|       7
---------------------------------------------------------------------------
 1487- 1536 (77.06/44.57)	NTGNANTPSATLASAASTTMTMTSGVAISTSVATAN.STLTTASTSSSSSS
 1545- 1595 (78.69/45.69)	NKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQpSALQTAGISGESSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.96|      33|      39|    1105|    1141|       8
---------------------------------------------------------------------------
 1105- 1141 (52.19/43.30)	DPTQEVQYRctcgFSAVMNRKFGN.NSGLFLEDEL..DII
 1146- 1181 (46.78/27.36)	DCGKEAEKR....FEALRATSTEHiNGGLRESEKLpdDLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.67|      16|      40|     220|     236|      10
---------------------------------------------------------------------------
  220-  236 (26.59/24.08)	ATKKLIGEWKQFYPiSC
  258-  273 (28.08/19.50)	AVEVLVAGVRMIYP.AC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.35|      32|      40|    1394|    1425|      11
---------------------------------------------------------------------------
 1394- 1425 (52.84/37.47)	GQHRPVSRL.LTDGIMR..VGS.TASKKLSEKLVAE
 1433- 1468 (40.51/26.69)	GNNEAFSKLkLYAQVCRydLGPyLASLPLDSSLLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.65|      24|      40|     787|     817|      12
---------------------------------------------------------------------------
  787-  812 (38.85/33.31)	TPGS.KKSANG.SDDKVSCKEskTGNLD
  828-  853 (38.80/15.78)	TPPSlEQHIMGfSPMNMNNKE..YGSMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.35|      20|     850|    1069|    1104|      16
---------------------------------------------------------------------------
 1083- 1104 (36.82/20.69)	DSCCI...CVCNMNIKGAdvGVYIP
 1897- 1919 (33.53/25.02)	DSPSIlsaCLVAMEPQGS..FVIMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.25|      15|      43|    1626|    1641|      17
---------------------------------------------------------------------------
 1626- 1641 (26.21/19.37)	TYPP....AIVVYIIdPFTY
 1668- 1686 (25.03/13.08)	TLPPhiksTVSVQII.PCQY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.06|      30|      41|     129|     160|      18
---------------------------------------------------------------------------
  129-  160 (49.51/40.45)	VRIGKWfvKP.YEKDEKPINKSEHLSCSFTFFL
  170-  200 (46.56/30.66)	VEINQH..QPvYLLSEEHITLAQQSNSPFQVIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.60|      16|     251|     944|     959|      19
---------------------------------------------------------------------------
  944-  959 (33.14/15.98)	PSGPA..MPFIKEGDGSN
 1194- 1211 (27.46/12.01)	PFGAAdqDPFPKSGVISN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19144 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCLRHKNLKPRNAGQQGQAPTLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVAMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPVEDRIDSLSQSFP
2) DLDNLFNSDEDELTPGSKKSANGSDDKVSCKESKTG
3) GPAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
4) SPVHSPGSHYPHGGDVGKGQGTDRLLSTEAH
5) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQPSALQTAGISGESSSLPIQPHPDVSESTMDRDKVGIPTDGD
416
774
946
2014
1523
579
809
1031
2044
1621










Molecular Recognition Features






MoRF SequenceStartStop




NANANA