Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLATGDLGKEKTQKRAKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNISGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1505 |
Position | Middle |
Organism | Saimiri boliviensis boliviensis (Bolivian squirrel monkey) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.687 |
Instability index | 52.98 |
Isoelectric point | 8.78 |
Molecular weight | 159849.15 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP19142 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 8| 397.83| 45| 50| 1000| 1044| 1 --------------------------------------------------------------------------- 577- 618 (36.63/ 6.40) .PAQdfSTLYGS........SPlerQNSSSG.S..PRMEI................CSGSNKTKKKKSSR 932- 971 (40.32/ 7.93) KPPK..RKKADT........EG...K.SPSH.SS.SNRPFTPPTStggS.......KSPGSSG....... 1000- 1044 (76.50/22.99) KPSS..HSQYTS........SG...SVSSSG.SK.SHHSHSSSSS...S.......SSASTSGKMKSSKS 1051- 1099 (44.56/ 9.70) KLSS...SIYSS........QG...S.SGSGqSKnSSQSGGKPGS...SpitkhglSSSSSSTKMK...P 1102- 1139 (45.98/10.29) KPSS.lMNPSLS........KP...NISPS.......HSRPPGGS...D.......KLASP...MKPVPG 1140- 1183 (50.19/12.04) TPPS...SKAKS........PI...SSGSGG.S...HMSGTSSSSgmkS.......SGLGSSGSL.SQKT 1184- 1228 (61.51/16.76) PPSS..NSCTAS........SS...SFSSSG.SS.MSSSQNQHGS...S.......KGKSPSRNKKPSLT 1233- 1284 (42.15/ 8.69) K.LK..HGVVTSgpggedpmDG...QMGVST.NS.SSHPMSSKHN...I.......SGGEFQGKREKSDK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 241.84| 52| 52| 1325| 1376| 2 --------------------------------------------------------------------------- 1286- 1328 (57.07/19.79) KSKVSTS..G.SSVDSSK.KTSESKNVGSTGV..akiIISKHD........................GGSP...............SI 1329- 1395 (83.56/32.75) KAKVTLQKPGESSGEGLRPQMASSKNYGSPLISG...STPKHERGSPS..................HSKSPaytpqnldsesesgsSI 1396- 1452 (54.48/18.52) AEKSYQNSP..SSDDGIRP...........LPEY...STEKHKKHKKEkkkvkdkdrdrdrdkdrdKKKSH...............SI 1453- 1486 (46.73/14.73) KPESWSKSP.ISSDQSL..SMTSN....TIL.ST...DRPS..RLSP......................................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 64.33| 13| 26| 251| 263| 3 --------------------------------------------------------------------------- 223- 237 (18.07/ 9.27) LPacFFLKFPQPIPV 251- 263 (24.14/15.32) IP..LFETQPTYVPL 279- 291 (22.11/13.29) IP..LNHNMRFYAAL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 122.74| 37| 50| 70| 117| 4 --------------------------------------------------------------------------- 70- 107 (60.44/60.48) NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD 120- 158 (62.30/34.83) NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 135.80| 36| 50| 824| 859| 5 --------------------------------------------------------------------------- 725- 765 (47.81/20.60) PAIG.TPLRDSSSS.....GHSQStlfDSDVFQTNNneNPYTDPADL 833- 870 (57.96/26.67) PMLG.GDNGETKFK.....GNSQA...DTVDFSIISvaGKALGPADL 880- 914 (30.03/ 9.97) PLLAtGDLGKEKTQkrakeGNGTS...N....STLS..GPGLDS... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 165.48| 43| 340| 25| 68| 6 --------------------------------------------------------------------------- 25- 68 (74.11/41.15) CYITSDMFY..VEVQlDPAGQ..LC...DVKVAHH.GENPVSC...PELVQQLRE 367- 409 (60.79/29.48) CPLSESRFS..VSFQ.HPVNDslVCvvmDVQDSTH.....VSC....KLYKGLSD 637- 678 (30.58/11.15) .......FSmdVDSQ.NPIFD..VNmtaDTLDTPHiTPAPSQCstpPTTYPQ... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 75.30| 20| 20| 457| 476| 7 --------------------------------------------------------------------------- 457- 476 (37.00/17.95) EDMVKKNLPPASSPGYGMTT 479- 498 (38.29/18.86) NPMSGTTTPTNTFPGGPITT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 73.82| 22| 25| 780| 803| 8 --------------------------------------------------------------------------- 768- 789 (37.73/17.29) DAAGSPSSDSPTNHFFHDGVDF 792- 813 (36.09/23.46) DLLNSQSQSGFGEEYFDESSQS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.04| 12| 422| 545| 556| 10 --------------------------------------------------------------------------- 545- 556 (27.54/10.62) SPTPPHHTPPPV 973- 984 (24.50/ 8.67) SQTPPGVATPPI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IKAKVTLQ 3) IRPLPEYSTEKHKKHKKEKKKVKDKDRD 4) ITIQIPK 5) KPSLTAVIDKLKHGV 6) RLSPDFMIGEEDDDLMDV 7) VAKIIISKH | 802 1328 1410 987 1224 1483 1313 | 808 1335 1437 993 1238 1500 1321 |
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