<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19141

Description Mediator of RNA polymerase II transcription subunit 1
SequenceSSYSPASASRVAGITGAHHHTKLIFVLLVERGLTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLATGDLGKEKTQKRAKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSIYSSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSSSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSSHPMSSKHNISGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1543
PositionMiddle
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.05
Grand average of hydropathy-0.661
Instability index52.45
Isoelectric point8.84
Molecular weight163776.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19141
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     397.83|      45|      50|    1038|    1082|       1
---------------------------------------------------------------------------
  615-  656 (36.63/ 6.55)	.PAQdfSTLYGS........SPlerQNSSSG.S..PRMEI................CSGSNKTKKKKSSR
  970- 1009 (40.32/ 8.08)	KPPK..RKKADT........EG...K.SPSH.SS.SNRPFTPPTStggS.......KSPGSSG.......
 1038- 1082 (76.50/23.17)	KPSS..HSQYTS........SG...SVSSSG.SK.SHHSHSSSSS...S.......SSASTSGKMKSSKS
 1089- 1137 (44.56/ 9.85)	KLSS...SIYSS........QG...S.SGSGqSKnSSQSGGKPGS...SpitkhglSSSSSSTKMK...P
 1140- 1177 (45.98/10.44)	KPSS.lMNPSLS........KP...NISPS.......HSRPPGGS...D.......KLASP...MKPVPG
 1178- 1221 (50.19/12.20)	TPPS...SKAKS........PI...SSGSGG.S...HMSGTSSSSgmkS.......SGLGSSGSL.SQKT
 1222- 1266 (61.51/16.92)	PPSS..NSCTAS........SS...SFSSSG.SS.MSSSQNQHGS...S.......KGKSPSRNKKPSLT
 1271- 1322 (42.15/ 8.85)	K.LK..HGVVTSgpggedpmDG...QMGVST.NS.SSHPMSSKHN...I.......SGGEFQGKREKSDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     241.84|      52|      52|    1363|    1414|       2
---------------------------------------------------------------------------
 1324- 1366 (57.07/21.67)	KSKVSTS..G.SSVDSSK.KTSESKNVGSTGV..akiIISKHD........................GGSP...............SI
 1367- 1433 (83.56/35.86)	KAKVTLQKPGESSGEGLRPQMASSKNYGSPLISG...STPKHERGSPS..................HSKSPaytpqnldsesesgsSI
 1434- 1490 (54.48/20.29)	AEKSYQNSP..SSDDGIRP...........LPEY...STEKHKKHKKEkkkvkdkdrdrdrdkdrdKKKSH...............SI
 1491- 1524 (46.73/16.13)	KPESWSKSP.ISSDQSL..SMTSN....TIL.ST...DRPS..RLSP.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.33|      13|      26|     289|     301|       3
---------------------------------------------------------------------------
  261-  275 (18.07/ 8.02)	LPacFFLKFPQPIPV
  289-  301 (24.14/13.23)	IP..LFETQPTYVPL
  317-  329 (22.11/11.49)	IP..LNHNMRFYAAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.74|      37|      50|     108|     155|       4
---------------------------------------------------------------------------
  108-  145 (60.44/56.25)	NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  158-  196 (62.30/32.36)	NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     158.39|      36|      50|     862|     897|       5
---------------------------------------------------------------------------
  763-  803 (47.81/24.56)	PAIG.TPLRDSSSS.....GHSQStlfDSDVFQTNNneN....PYTDPADL
  841-  870 (22.59/ 6.67)	........GEEYFD.....ESSQS..gDNDDFK......gfasQALNTLGV
  871-  908 (57.96/31.76)	PMLG.GDNGETKFK.....GNSQA...DTVDFSIISvaG....KALGPADL
  918-  952 (30.03/11.95)	PLLAtGDLGKEKTQkrakeGNGTS...N....STLS..G....PGLDS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     178.44|      50|      52|     658|     707|       6
---------------------------------------------------------------------------
  552-  597 (42.85/17.17)	GHGEDFS.KV.SQNPILTslLQITGNGGSTigssptpPHHTPPPvSSM..................
  670-  724 (85.78/42.67)	FQRELFSMDVDSQNPIFD..VNMTADTLDT.......PHITPAP.SQCstPPttyPQPV.PHPQPS
  725-  761 (49.81/21.30)	IQRMVRLSSSDSIGP..D..V...................TDIL.SDI..AE...EASKlPSTSDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.73|      38|     340|      63|     106|       7
---------------------------------------------------------------------------
   63-  106 (56.53/53.99)	CYITSDMFYVEVQlDPAGQ..LC...DVKVAHHgenpVSCpELVQQLRE
  405-  447 (61.20/37.54)	CPLSESRFSVSFQ.HPVNDslVCvvmDVQDSTH....VSC.KLYKGLSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19141 with Med1 domain of Kingdom Metazoa
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