<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19118

Description Mediator of RNA polymerase II transcription subunit 13
SequenceCMLINCLVFHSPCLESCNTSVFQLTKKMFLKFLFIWMSFLLVLFFLFSFFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQYKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTTGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPNSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYRLPPCEDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFVDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSAQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLLMCQTTFLPQAEGTRKSQEPPISLLLLLQSQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNSGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYSSEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2160
PositionMiddle
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.08
Grand average of hydropathy-0.362
Instability index58.82
Isoelectric point5.72
Molecular weight237486.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19118
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     119.01|      25|      28|    1545|    1570|       1
---------------------------------------------------------------------------
  396-  410 (25.34/ 6.18)	PGF.S..........AGPSS.SSS...LPP
  998- 1018 (28.09/ 7.61)	PTP.RTPRTPRTPRGGGTAS.GQ.......
 1544- 1568 (38.85/13.18)	PGI.SQISTTSSSGFSGSVG.GQN...PST
 1569- 1597 (26.72/ 6.90)	GG.iSTDRTQGNIGCGGDTDpGQSssqPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.32|      33|     913|     348|     391|       2
---------------------------------------------------------------------------
  355-  391 (56.44/42.39)	ASNPATWDFvDPTqrvSCSCSRHKLLKRCAVGPNRPP
 1504- 1536 (58.88/22.74)	AAPPAGSAF.NPT...SNSSTTNPAASSSASGSSVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     425.45|     112|     544|     202|     320|       3
---------------------------------------------------------------------------
  202-  320 (179.73/127.58)	LKEEDEL..GYDDDFPVAVEVIVGGVRMvyPSafvlISQNDIPVPQSVASAgGHITVGQQ....GLGSVKDPSNC..GMPLTPPTSPEQAILGESGGMQSAT.SHLGSQDG.GMITMHSPK........RSGKIPP.K
  631-  718 (97.71/53.44)	....................................IWQDKQPQMQPLHFV.DPLPLSQQ.pgdSLGEVNDPYTFedGDIKYIFTANKKC...KQGTEKDSL.KKNKSEDGfGTKDVTTPG........HSTPVPDgK
  756-  874 (148.01/88.19)	LHDLDNIfdNSDDDELGAVSPALRSSKM..PT....VGTEDRPLGKD.....GRAAVPYPptvaDLQRMF.PTPP..SLEQHPAFSP...VMNYKDGISSETvTALGMMES.PMVSMVSAQltefkmevEDGLGSP.K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      27|      28|    2020|    2047|       4
---------------------------------------------------------------------------
 2020- 2047 (41.86/24.78)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2049- 2078 (46.00/22.99)	YFV.STAKAENLpqwFWSSCPQAQNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1076|    1100|       5
---------------------------------------------------------------------------
 1076- 1100 (51.64/35.00)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1103- 1131 (36.91/22.69)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    1969|    1991|       6
---------------------------------------------------------------------------
 1969- 1991 (24.82/19.89)	SPNNDdmfvDLPFPDDmDNDIGI
 2000- 2017 (34.25/13.43)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.81|      21|      22|     898|     918|       7
---------------------------------------------------------------------------
  898-  918 (39.11/18.01)	MFAPLKMLPSHC.LLPLKIPDA
  920-  940 (34.75/15.17)	LFRPSWAIPPKIeQLPMP.PAA
 1039- 1055 (25.96/ 9.43)	..RPLNSVEPAT.MQP..IPEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.10|      23|      27|    1690|    1716|       8
---------------------------------------------------------------------------
 1694- 1716 (43.93/34.23)	IQYLKSM..AFSVYCQCR...RPLPTQI
 1718- 1745 (29.17/10.97)	IKSLTGFgpAASIEMTLKnpeRPSPIQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.99|      74|    1266|     105|     184|       9
---------------------------------------------------------------------------
  105-  184 (115.18/101.79)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1374- 1450 (124.81/86.13)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.50|      15|      16|    1184|    1199|      10
---------------------------------------------------------------------------
 1184- 1199 (22.11/15.51)	Q..PFASLSFlDYISSNN
 1201- 1217 (24.40/12.37)	QtlPCVSWSY.DRVQADN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.34|      12|      27|    1823|    1834|      11
---------------------------------------------------------------------------
 1823- 1834 (24.58/12.44)	KIGLQKLWEWCI
 1853- 1864 (22.75/11.02)	RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.09|      17|      22|    1325|    1341|      12
---------------------------------------------------------------------------
 1325- 1341 (32.92/16.16)	SPEPLPI.PTLLV...GYDKD
 1346- 1366 (23.18/ 9.13)	SPFSLPFwERLLLdpyGGHRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.43|      11|      16|     552|     563|      15
---------------------------------------------------------------------------
  552-  563 (15.53/11.86)	GQRlPLMAEVSE
  569-  579 (20.90/11.33)	GIR.PSNPESSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.35|      19|     910|     330|     349|      16
---------------------------------------------------------------------------
  330-  349 (32.79/25.07)	WKECiLNRTQYKRSQMSTPT
 1221- 1239 (37.56/24.00)	WTEC.FNALEQGRQYVDNPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.08|      17|     136|    1649|    1666|      17
---------------------------------------------------------------------------
 1649- 1666 (26.88/25.02)	WLLSLMRCyTEMLDNLPE
 1672- 1688 (31.20/22.34)	FILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.22|      15|      25|    1926|    1940|      18
---------------------------------------------------------------------------
 1926- 1940 (25.53/14.32)	TALNMQSSQLNTPQD
 1951- 1965 (25.68/14.45)	TSSTIQVAPANYPNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19118 with Med13 domain of Kingdom Metazoa
Unable to open file!