<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19115

Description Mediator of RNA polymerase II transcription subunit 13
SequenceANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQYKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTTGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPNSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYRLPPCEDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFVDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSAQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLLMCQTTFLPQAEGTRKSQEPPISLLLLLQSQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNSGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYSSEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2207
PositionMiddle
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.07
Grand average of hydropathy-0.390
Instability index57.80
Isoelectric point5.64
Molecular weight242484.55
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19115
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.25|      17|      22|    1556|    1577|       1
---------------------------------------------------------------------------
 1556- 1573 (25.70/ 7.86)	GSAFNPTSnSSTTNPAAS
 1578- 1594 (28.55/12.91)	GSSVPPVS.SSASAPGIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.68|      20|      22|     945|     965|       2
---------------------------------------------------------------------------
  945-  965 (35.03/17.91)	MFAPLKMLPSHC.LLPLKiPDA
  967-  987 (34.65/14.14)	LFRPSWAIPPKIeQLPMP.PAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      17|      22|     772|     793|       3
---------------------------------------------------------------------------
  759-  775 (30.29/22.70)	TPV.PD...GKNAMSIFSSAT
  777-  797 (18.91/21.74)	TDVrQDnaaGRAGSSSLTQVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     159.92|      28|      28|    1030|    1057|       4
---------------------------------------------------------------------------
 1021- 1048 (42.12/20.72)	NSAAPASNSGAGVLPSPATPRFSVPTPR
 1049- 1076 (47.18/24.31)	TPRTPRTPRGGGTASGQGSVKYDSTDQG
 1599- 1625 (41.68/20.41)	TSSSGFSGSVGGQNPSTGGISTDRT.QG
 1626- 1644 (28.95/11.38)	N.....IGCGGDTDPGQSSSQ...PSQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      27|      28|    2067|    2094|       5
---------------------------------------------------------------------------
 2067- 2094 (41.86/25.93)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2096- 2125 (46.00/24.06)	YFV.STAKAENLpqwFWSSCPQAQNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1123|    1147|       6
---------------------------------------------------------------------------
 1123- 1147 (51.64/29.61)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1150- 1178 (36.91/19.15)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.11|      12|      23|     539|     550|       7
---------------------------------------------------------------------------
  539-  550 (24.23/11.82)	NPMDSPNSPISP
  565-  576 (22.89/10.66)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     284.24|      88|     547|     249|     367|       8
---------------------------------------------------------------------------
  255-  357 (133.35/127.16)	LGYDDDFPVAvevivggvrmvYPSAFVLIsQNDIPVPQSVAS..AGGHITVGQQGLGSvKDPSNCGMPLTPPTSPEQAILGESgGMQsATSHLGSQDGGMITMHS
  840-  929 (150.88/77.22)	LGKDGRAAVP...........YPPTVADL.QRMFPTPPSLEQhpAFSPVMNYKDGISS.ETVTALGMMESPMVSMVSAQLTEF.KME.VEDGLGSPKPEEIKDFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.42|      18|      22|    1694|    1713|       9
---------------------------------------------------------------------------
 1694- 1713 (30.77/24.74)	NFWLLSLMRC.YteMLDNLPE
 1717- 1735 (29.64/17.00)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.19|      18|      23|    1997|    2014|      10
---------------------------------------------------------------------------
 1973- 1989 (21.38/ 9.40)	.TALNMQSS...QLNTPQDAS
 1997- 2014 (31.10/17.47)	PTSSTIQVA...PANYPNEDG
 2017- 2037 (26.70/13.81)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.09|      17|      22|    1372|    1388|      11
---------------------------------------------------------------------------
 1372- 1388 (32.92/20.15)	SPEPLPI.PTLLV...GYDKD
 1393- 1413 (23.18/11.48)	SPFSLPFwERLLLdpyGGHRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.52|      20|      23|      61|      80|      12
---------------------------------------------------------------------------
   61-   80 (38.38/29.29)	QANLLCVWRRDVKPDCKELW
   87-  106 (35.14/26.06)	EPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.99|      74|    1266|     152|     231|      14
---------------------------------------------------------------------------
  152-  231 (115.18/84.49)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1421- 1497 (124.81/71.46)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.18|      25|      27|    1855|    1881|      15
---------------------------------------------------------------------------
 1855- 1881 (40.61/35.67)	I...ALPNRSRRSKVSarKIGLQKLWEWCI
 1884- 1911 (39.57/27.27)	VqmtSLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.32|      17|      22|    1232|    1252|      16
---------------------------------------------------------------------------
 1235- 1252 (27.29/25.39)	SLSFlDYI.SSNNRQTLPC
 1254- 1271 (31.03/13.75)	SWSY.DRVqADNNDYWTEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.78|      18|      27|     458|     475|      18
---------------------------------------------------------------------------
  458-  475 (29.89/19.95)	PASSKHKTTERQEKGDKL
  487-  504 (30.89/20.90)	PSVAEELCMEQDTTGQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.43|      12|      27|     359|     370|      21
---------------------------------------------------------------------------
  359-  370 (22.36/14.60)	KRSGKIPPKLHN
  388-  399 (21.06/13.18)	KRSQMSTPTLEE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19115 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVP
2) CAVGPNRPPTISQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTTGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPNSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLEL
3) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
5) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLH
6) PPKYQTPPAAAQGQATPGNAGPLAPNSGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAH
7) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
800
430
2037
732
301
1522
1000
849
585
2085
798
369
1670
1097










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIW
674
679