<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19114

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKEMESHVFLKAKTRDEYLSLVARLIIHFRDIHPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTATPQSEYHASWRICHFLQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSSIPLGRQPMAQVFTGQPHMFLSLGCSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length732
PositionTail
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.04
Grand average of hydropathy-0.595
Instability index81.81
Isoelectric point9.37
Molecular weight80907.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19114
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.15|      18|      20|     276|     294|       1
---------------------------------------------------------------------------
  248-  265 (32.73/ 7.54)	QPPMQQPQPPPSQALPQQ
  276-  293 (40.42/ 8.57)	QPPPQPQQPPVAQNQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.20|      20|      20|     199|     218|       2
---------------------------------------------------------------------------
  199-  218 (37.27/ 9.95)	LIKLHHQNQQQIQQQQQQLQ
  222-  241 (38.93/10.72)	QLQLQQQQQQQQQQQQQALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     145.27|      30|      30|     415|     444|       3
---------------------------------------------------------------------------
  169-  196 (34.87/ 7.85)	.AQQ.......SAMQQ.QFQAVVQQ......QQQQL.QQQQQQQ
  310-  346 (34.37/ 7.62)	LPGQ.......MLYTQPPLKFVRAPmvvqqpQVQPQvQQQTAVQ
  376-  404 (38.23/ 9.42)	FPPT.......TAVSAIPSSSIP.L......GRQPM.AQVFTGQ
  405-  440 (37.80/ 9.22)	.PHMflslgcsSGPAPSPSSFLPSP......SPQPS.QSPVTAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     314.71|      79|     124|     491|     569|       6
---------------------------------------------------------------------------
   68-  121 (49.10/18.18)	...............DIHPMNALQSLTGGPAagaagigmpPRGPGQ.SLG.GMG.GLSAMGQ....PMSLSG..QP.PP...................
  491-  569 (136.76/64.85)	RRMINKIDKNEDRKKDLSKMKSLLDILTDPS.........KRCPLK.TLQ.KCEIALEKLKN....DMAVPT..PP.PPPVPPTKQ.QYLCQPLLDAV
  580-  614 (32.44/ 9.31)	.............................................H.SLY.RTFV..PAM.......TAIHG..PPiTAPVVCTRK.R....RLEDDE
  615-  696 (96.41/43.37)	RQSIPSVLQGEVARLD...PKFLVNL..DPS.........H.CSNNgTVHlICKLDDKDLPSvpplELSVPAdyPA.QSPLWIDRQwQYDANPFLQSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19114 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTAT
2) APMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSS
3) LSLGCSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQ
4) QQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
74
326
409
233
138
389
475
312










Molecular Recognition Features






MoRF SequenceStartStop




NANANA