<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19113
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKEMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQQFQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA |
Length | 654 |
Position | Tail |
Organism | Saimiri boliviensis boliviensis (Bolivian squirrel monkey) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae>
Saimiriinae> Saimiri.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.776 |
Instability index | 89.59 |
Isoelectric point | 9.38 |
Molecular weight | 73169.20 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP19113
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 192.50| 36| 36| 316| 351| 3
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226- 262 (44.48/ 8.26) PPQSQTQPlvSQAQA....LPGQMLYTQP...PLKFVRAPmvVQ
263- 300 (44.75/ 8.36) QPQVQPQV..QQQTAvqtaQTAQMVAPGVQVSQSS.LPML..S.
317- 351 (63.70/15.38) PPQPSPQP..GQPGS....QPNSNVSSGPAPSPSSFLPSP..S.
352- 381 (39.56/ 6.44) .PQPSQSP..VTART....PQNFSV...PSPGP...LNTP.vNP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 109.11| 28| 63| 70| 108| 4
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80- 100 (35.57/12.46) ........AQ.QFQQQAALQQQQQQQQFQA
144- 173 (43.02/ 8.77) QQQQLQRmAQlQLQQQQQQQQQQQQQALQA
178- 199 (30.53/ 6.47) QQPPMQQ...pQPPPSQALPQQLQQ.....
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.40| 23| 27| 429| 455| 5
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420- 447 (35.23/20.75) DKNEdrkkdLSKMKSLLDILTDPSKRCP
452- 476 (39.17/15.61) QKCE...iaLEKLKNDMAVPTPPPPPVP
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