<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19111

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKEMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTATPQTQQFQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length765
PositionTail
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.03
Grand average of hydropathy-0.670
Instability index85.86
Isoelectric point9.49
Molecular weight84008.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19111
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.98|      17|      19|     156|     173|       1
---------------------------------------------------------------------------
  182-  199 (28.71/ 7.67)	AVVQQQQQQLQqQQQQQQ
  223-  239 (32.26/ 6.68)	AQLQLQQQQQQ.QQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     745.36|     150|     154|     246|     399|       2
---------------------------------------------------------------------------
   69-  219 (152.63/34.60)	..IHNK.KSQASV.....SDPMNAL.QSLTGG...................PAAGAAGIGMPPRGPGQSLggmgglsaMGQPMSLSGQ....PP.PGTSGMAPhnMAV.....vstATPQTQ.QFQQQAALQQ.QQQQQQF....QAQQSAMQQQFQavvqqqqqqlqqqqqqqqHL.......IKLHHQ...NQQQIQQQQ.QQL
  246-  399 (265.80/70.58)	PPIQQP.PMQQPQ.....PPPSQALPQQLQQMHHPQHH...QPPPQPQQ.PPVAQNQPSQLPPQSQTQPL........VSQAQALPGQmlytQP.PLKFVRAP..MVV........QQPQVQPQVQQQTAVQT.AQTAQMVAPGVQMITEALAQGGM..................HVRARFPPTTAVSAI...PSSSIPLGR.QPM
  408-  561 (185.70/43.98)	PMLSSPsPGQQVQtpqsmPPPPQPSPQPGQPGSQPNSNvssGPAPSPSSfLPSPSPQPSQSPVTART.P...........QNFSVP......SPgPLNTPVNP..SSV........MSPAGSSQAEEQQYLDKlKQLSKYIEPLRRMINKIDKNEDR....................KKDLSKMKSLLDIltdPSKRCPLKT....
  573-  684 (141.23/31.37)	....KN.DMAVPT.....PPPP.PVP........PTKQ...QYLCQPLL.DAVLANIRSPVFNHSLYRTF........VPAMTAIHG......P.P...ITAP..VVCtrkrrledDERQSIPSVLQ.......GEVA.........................................RLDPKFLVNLD...PSHCSNNGTvHLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19111 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLSAMGQPMSLSGQPPPGTSGMAPHNMAVVSTATPQTQQFQQQAALQQQQQQQQFQAQQ
2) QQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
3) QQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQ
4) RAPMVVQQPQVQPQVQQQTAVQTAQTAQMVAPGVQMITEALAQGGMHVRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
70
235
194
327
173
314
233
515










Molecular Recognition Features






MoRF SequenceStartStop




NANANA