<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19090

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNINFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRNVVDPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPSSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPGSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLDPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQTGVRSTAILPEQQQQQQQQQQQQQQYHIRQQQQQQILRVRHWDCIWDAGTWGRGEAQFLPTQLPRLNKAVYPNTQQSGWPLVVLEVSYLPPFCFLGVIEGETWTLSAGYPRVGFFLGSSLRREGSRPQAPSLLPHPLPSALQF
Length2185
PositionKinase
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index52.64
Isoelectric point6.62
Molecular weight243108.75
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     734.97|     213|     230|     350|     578|       1
---------------------------------------------------------------------------
  217-  424 (250.03/152.10)	..........................GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPSSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH.......YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLRE
  425-  660 (320.03/183.60)	IEQQIKERGQAVevrwSFDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCE..LIRHdvfshnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLED
  664-  814 (164.91/81.96)	SESMDIDPGSSV....LFEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ.............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     311.92|      63|      76|    1844|    1906|       2
---------------------------------------------------------------------------
 1740- 1811 (72.92/34.86)	..EPLPLPPEDEEP..PAPTLLePEKKAPEPPktDK.PG.AA...PpsteerkkKST...KGKKR.SQPAT.KTEDY.GMGPgrSGP
 1844- 1906 (118.35/61.71)	QNQPLPAGGPRVDP..YRPVRL.PMQKLPTRP..TY.PG.VL...P........TTM...TGVMG.LDPSSYKTSVYRQQQP..AVP
 1920- 1973 (56.13/24.93)	QSQGM.LGQSSVHQ..MTPS...SSYGLQTSQ..GYtPY.VS...H........VGLqqhTGPAGtMVPPSYSS.............
 1974- 2030 (64.51/29.88)	..QPYQSTHPSTNPtlVDPTR.....HLQQRP..S...GyVHqqaP........TYG...HGLTS.TQRFSHQT...LQQTP..MI.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     854|     868|       3
---------------------------------------------------------------------------
  854-  868 (26.85/20.30)	LEQITSFALG.MSYHL
  870-  885 (23.14/16.26)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.20|      14|     205|    1092|    1106|       8
---------------------------------------------------------------------------
 1092- 1105 (29.50/19.62)	EWLG..VLKALCCSSN
 1291- 1306 (24.70/ 9.97)	EWVGerCLKSLCEDSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1028|    1040|       9
---------------------------------------------------------------------------
 1028- 1040 (25.11/16.77)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/12.67)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.46|      22|     205|     913|     938|      12
---------------------------------------------------------------------------
  913-  938 (29.83/30.59)	SDLvgSYTTSLClCIVAVLRHYHaCL
 1121- 1142 (39.62/22.69)	SDL..SFHDSLA.TFVAILIARQ.CL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      14|      16|    1329|    1343|      13
---------------------------------------------------------------------------
 1329- 1343 (22.34/20.45)	HRLLDNEDgENPQRQ
 1346- 1359 (26.58/18.02)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.60|       8|      16|    1671|    1680|      14
---------------------------------------------------------------------------
 1671- 1680 (10.11/ 9.77)	IFkkEGLQVS
 1690- 1697 (15.50/ 7.25)	LF..EGLKPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19090 with Med12 domain of Kingdom Metazoa
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