<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19073

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHQEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVAAADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDRFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNQGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDETLVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLQLDGLARAPGQPKIDHLRRLHLGAYPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPGASEAPRASVQLGPRPTHHPPSWDPRSLDHLHPEDQPRGLGVQADPVVTWLGAPASVSLPRLQWMLNLDKLRLGEGRSNKRPPRPGLCPSRQCPGPTRDLHSVLGSLCPLGLSLNHSALTGAQRMPGPGRPQ
Length960
PositionTail
OrganismSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Platyrrhini> Cebidae> Saimiriinae> Saimiri.
Aromaticity0.06
Grand average of hydropathy-0.057
Instability index48.89
Isoelectric point8.30
Molecular weight105822.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19073
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.35|      45|      74|     815|     861|       1
---------------------------------------------------------------------------
  815-  861 (83.73/49.33)	RWIKNCLAVE.GRGPGASEAPRASvqLGPRPTHHPPSWDPRS.LDHLHP
  891-  937 (79.62/41.70)	QWMLNLDKLRlGEGRSNKRPPRPG..LCPSRQCPGPTRDLHSvLGSLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.24|      27|     132|      22|      48|       2
---------------------------------------------------------------------------
   22-   48 (53.17/32.33)	EKWSKSTHCPSVPLACAWSCRNLIAFT
  157-  183 (49.06/29.23)	EKFSRVKFSPSLTLFGGKPMEGWIAVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.35|      22|     146|     721|     742|       4
---------------------------------------------------------------------------
  695-  719 (21.21/ 6.93)	..KLWICCRDEGPA..SepdETLVDEccL
  721-  742 (39.98/18.97)	PSQLLIPSLDWLPA..S...DGLVSR..L
  744-  763 (20.16/ 6.25)	PKQPLRLQFGRAPTlqL...DGL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.06|      61|     200|      72|     136|       5
---------------------------------------------------------------------------
   72-  136 (99.53/75.15)	DLHSipSEHQEAITCLEW...DQSGSRLL..SADADGQIKCWSM.ADHL.ANSWESSVGSLVeGD..PIVaLSW
  270-  339 (85.53/51.22)	DLNR..KDRFPAITHLKFlarDMSEQVLLcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVV.GDkqPTI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.84|      31|      74|     551|     583|       7
---------------------------------------------------------------------------
  551-  583 (49.75/41.49)	LFLIAISSTLKSLLRP.H.FLNtpDKSPGDRLTEI
  626-  658 (47.09/31.45)	LYLLASLPNQGSLLRPgHsFLR..DGTSLGMLREL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19073 with Med16 domain of Kingdom Metazoa
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