<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19053

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDDLGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGVQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPLNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2210
PositionMiddle
OrganismRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index57.79
Isoelectric point5.67
Molecular weight242729.02
Publications
PubMed=25362486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19053
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.62|      21|      28|    1595|    1620|       1
---------------------------------------------------------------------------
 1578- 1594 ( 5.10/ 6.07)	...SASGSSVppvSSS....ASA...P....
 1600- 1620 (39.60/16.48)	STTSSSGFSG...SVG....GQN...PSTGG
 1622- 1649 (28.92/ 8.51)	STDRTQGNIG...CGGdtdpGQSssqPSQDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2068|    2095|       2
---------------------------------------------------------------------------
 2068- 2095 (37.05/29.09)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2098- 2126 (44.88/25.32)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.02|      27|      28|    1010|    1036|       3
---------------------------------------------------------------------------
 1022- 1049 (34.96/11.89)	VTLNSTAPASNSGAG...........vlpsP........ATPRFSVP
 1050- 1091 (38.32/13.72)	TPRTPRTPRTPRGGGtasgqgsvkydstdqG.....SPASTPSTTRP
 1533- 1573 (24.74/ 6.32)	.PAAAQGQATPGNAG.....plapngsaapPagsafNPTSNSSTTNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     237.93|      45|     546|     941|     986|       4
---------------------------------------------------------------------------
  307-  335 (39.64/16.44)	...VG..QQGLGSVK.DPSNCGMPLTPPTS.....PEQAI........
  845-  875 (48.47/19.52)	....G..KDGRAAVP.YP.........PTVAD.LQRMFPTPPSLEQHP
  942-  986 (83.43/41.82)	QPFVG..SSMFAPLKMLPSHCLLPLKIPDACL.FRPSWAIPPKIEQLP
 1486- 1532 (66.38/30.94)	QPWSGeeNDNHSRLKLYAQVCRHHLAPYLATLqLDSSLLIPPKY.QTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.82|      26|      28|    1858|    1884|       5
---------------------------------------------------------------------------
 1858- 1884 (42.51/34.41)	IALPSRSRRSkVSAR..KIGLQKLWEWCI
 1887- 1914 (43.32/29.80)	VQMTSLPWRV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      24|     543|     554|       6
---------------------------------------------------------------------------
  543-  554 (24.80/12.60)	NPMDSPHSPISP
  569-  580 (22.89/10.90)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.21|      18|      24|    1697|    1716|       7
---------------------------------------------------------------------------
 1697- 1716 (29.95/25.25)	NFWLLSLMRC.YteMLDNLPE
 1720- 1738 (28.26/17.00)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.08|      21|     113|     690|     715|       9
---------------------------------------------------------------------------
  693-  715 (30.68/28.33)	LHFLDPLpLSQQPGDSLGEVNdP
  807-  827 (38.40/15.66)	LHDLDNI.FDNSDDDELGAVS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.52|      17|     547|      68|      87|      10
---------------------------------------------------------------------------
   68-   84 (33.29/26.29)	LLCVWRRDVKPDCKELW
   94-  110 (29.23/12.26)	LVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1266|     156|     189|      12
---------------------------------------------------------------------------
  156-  189 (52.23/48.64)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1425- 1456 (59.04/44.03)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1132|    1158|      13
---------------------------------------------------------------------------
 1132- 1151 (40.30/34.24)	CICACNMNIK.GADVGLYIPD
 1162- 1182 (33.83/13.48)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      11|      24|    2030|    2041|      14
---------------------------------------------------------------------------
 2030- 2041 (17.73/14.41)	PFPDDmDNDIGI
 2057- 2067 (21.55/11.56)	PSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.06|      18|      22|    1230|    1250|      15
---------------------------------------------------------------------------
 1233- 1250 (32.44/25.18)	HTQPFASLSFLDYISSNN
 1252- 1269 (34.61/17.56)	QTLPCVSWSYDRVQADNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.99|      29|     485|     243|     302|      16
---------------------------------------------------------------------------
  251-  293 (33.84/79.39)	EESKEEddlgydddFPVAVeVIVGgvrmvYPSAFVLISQNDIP
 1374- 1402 (54.15/22.42)	EESPEP........LPIPT.LLVG.....YDKDFLTISPFSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.02|      21|     105|     512|     532|      17
---------------------------------------------------------------------------
  512-  532 (35.37/20.06)	G..IDSSLEVSS.SRKYDKQMAVP
  620-  639 (37.53/21.77)	G..I.RPLNPES.SEKWWHSYRLP
  653-  676 (25.12/11.90)	GerCDAKMEVNSeSTALQRLLAQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19053 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVP
2) ECILNRTQSKRSQMSTPTLEEEPASNPATWDFV
3) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
4) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
5) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGVQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
6) KRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYG
7) PPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADS
8) VGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
804
383
2040
736
305
432
1526
1004
853
415
2088
802
373
584
1670
1101










Molecular Recognition Features






MoRF SequenceStartStop




1) KRFKIW
678
683