<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19053

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDDLGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGVQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPLNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2210
PositionMiddle
OrganismRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index57.79
Isoelectric point5.67
Molecular weight242729.02
Publications
PubMed=25362486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19053
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.62|      21|      28|    1595|    1620|       1
---------------------------------------------------------------------------
 1578- 1594 ( 5.10/ 6.07)	...SASGSSVppvSSS....ASA...P....
 1600- 1620 (39.60/16.48)	STTSSSGFSG...SVG....GQN...PSTGG
 1622- 1649 (28.92/ 8.51)	STDRTQGNIG...CGGdtdpGQSssqPSQDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2068|    2095|       2
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 2068- 2095 (37.05/29.09)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2098- 2126 (44.88/25.32)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.02|      27|      28|    1010|    1036|       3
---------------------------------------------------------------------------
 1022- 1049 (34.96/11.89)	VTLNSTAPASNSGAG...........vlpsP........ATPRFSVP
 1050- 1091 (38.32/13.72)	TPRTPRTPRTPRGGGtasgqgsvkydstdqG.....SPASTPSTTRP
 1533- 1573 (24.74/ 6.32)	.PAAAQGQATPGNAG.....plapngsaapPagsafNPTSNSSTTNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     237.93|      45|     546|     941|     986|       4
---------------------------------------------------------------------------
  307-  335 (39.64/16.44)	...VG..QQGLGSVK.DPSNCGMPLTPPTS.....PEQAI........
  845-  875 (48.47/19.52)	....G..KDGRAAVP.YP.........PTVAD.LQRMFPTPPSLEQHP
  942-  986 (83.43/41.82)	QPFVG..SSMFAPLKMLPSHCLLPLKIPDACL.FRPSWAIPPKIEQLP
 1486- 1532 (66.38/30.94)	QPWSGeeNDNHSRLKLYAQVCRHHLAPYLATLqLDSSLLIPPKY.QTP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.82|      26|      28|    1858|    1884|       5
---------------------------------------------------------------------------
 1858- 1884 (42.51/34.41)	IALPSRSRRSkVSAR..KIGLQKLWEWCI
 1887- 1914 (43.32/29.80)	VQMTSLPWRV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      24|     543|     554|       6
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  543-  554 (24.80/12.60)	NPMDSPHSPISP
  569-  580 (22.89/10.90)	ESLDPPSVPVNP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.21|      18|      24|    1697|    1716|       7
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 1697- 1716 (29.95/25.25)	NFWLLSLMRC.YteMLDNLPE
 1720- 1738 (28.26/17.00)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.08|      21|     113|     690|     715|       9
---------------------------------------------------------------------------
  693-  715 (30.68/28.33)	LHFLDPLpLSQQPGDSLGEVNdP
  807-  827 (38.40/15.66)	LHDLDNI.FDNSDDDELGAVS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.52|      17|     547|      68|      87|      10
---------------------------------------------------------------------------
   68-   84 (33.29/26.29)	LLCVWRRDVKPDCKELW
   94-  110 (29.23/12.26)	LVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1266|     156|     189|      12
---------------------------------------------------------------------------
  156-  189 (52.23/48.64)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1425- 1456 (59.04/44.03)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.13|      20|      28|    1132|    1158|      13
---------------------------------------------------------------------------
 1132- 1151 (40.30/34.24)	CICACNMNIK.GADVGLYIPD
 1162- 1182 (33.83/13.48)	CGFSAIMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      11|      24|    2030|    2041|      14
---------------------------------------------------------------------------
 2030- 2041 (17.73/14.41)	PFPDDmDNDIGI
 2057- 2067 (21.55/11.56)	PSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.06|      18|      22|    1230|    1250|      15
---------------------------------------------------------------------------
 1233- 1250 (32.44/25.18)	HTQPFASLSFLDYISSNN
 1252- 1269 (34.61/17.56)	QTLPCVSWSYDRVQADNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.99|      29|     485|     243|     302|      16
---------------------------------------------------------------------------
  251-  293 (33.84/79.39)	EESKEEddlgydddFPVAVeVIVGgvrmvYPSAFVLISQNDIP
 1374- 1402 (54.15/22.42)	EESPEP........LPIPT.LLVG.....YDKDFLTISPFSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.02|      21|     105|     512|     532|      17
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  512-  532 (35.37/20.06)	G..IDSSLEVSS.SRKYDKQMAVP
  620-  639 (37.53/21.77)	G..I.RPLNPES.SEKWWHSYRLP
  653-  676 (25.12/11.90)	GerCDAKMEVNSeSTALQRLLAQP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19053 with Med13 domain of Kingdom Metazoa
Unable to open file!