<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19051

Description Mediator of RNA polymerase II transcription subunit 13
SequenceCMLTNCSVFHSACLESCNTSVFQLTNFFLFGCPFYCFVFFFFLFFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDDLGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGVQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPLNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2154
PositionMiddle
OrganismRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.08
Grand average of hydropathy-0.365
Instability index58.67
Isoelectric point5.69
Molecular weight236651.33
Publications
PubMed=25362486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP19051
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     503.63|     107|     112|     764|     870|       1
---------------------------------------------------------------------------
  470-  556 (111.38/38.38)	...............DKQMAV.PSRN.TSKQMNLNPMD.SP.........HSPISPLP.PTLSPQPRGQETesldPPS.....VPVNPAL.....Y.GN..GLEL.QQLSTLD....DRTVL......VGQRLPLMAEV
  558-  677 (125.79/44.19)	ETALYCGIRPLNPesSEKWWHSYRLP.PSD....DAEF.RPpelQGErcDAKMEVNSE.STA..LQRLLAQ....PNKrfkiwQDKQPQMQP.LHF.LDplPLSQ.QPGDSLG...EVNDPYtfedgdIKYIFTANKKC
  764-  857 (145.36/52.08)	...............DELGAVSPALR.PSKIPTVGTED.RP...LGK..DGRAAVPYP.PTVADLQRMFPT....PPS.....LEQHPAFSPVMNY.KD..GISS.ETVTALG...MMESPM......VSMVSTQLTEF
  858-  963 (121.10/42.30)	KMEVEDGLGSPKP..EEIKDFSYVHKvPSFQPFVGSSMfAP...LKM.lPSHCLLPLKiPDACLFRPSWAI....PPK.....IEQLP.MPPAATFiRD..GYNNvPSVGSLAdpdYLNTPQ......MN.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     329.06|     111|    1266|     100|     361|       2
---------------------------------------------------------------------------
  165-  294 (162.33/206.16)	TGQAYKMSDPATRKLieEWQYFYPMVLK...KKEESKEEddlgydddFPVAVeVIVGgvrmvYPSAFVLISQNDIPVPQS..VASAGGH.....ITVGQ.............QGLGSVKDPSNCGM..PLTPPTspEQAIL..GESgGVQSAASHLV
 1287- 1424 (166.73/19.76)	TGRTWENIQHVQGPL..TWQQFHKMAGRgtyGSEESPEP........LPIPT.LLVG.....YDKDFLTISPFSLPFWERllLDPYGGHrdvayIVVCPeneallegaktffRDLSAVYEMCRLGQhkPICKVL..RDGIMrvGKT.VAQKLTDELV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.09|      25|      28|    1539|    1564|       3
---------------------------------------------------------------------------
  395-  414 (25.57/ 8.96)	.....AGPSSSSSLPPPAS.SKHKTT
 1522- 1546 (40.77/20.12)	SASGSSVPPVSSSASAPGI.SQISTT
 1547- 1571 (34.75/15.70)	SSSGFSGSVGGQNPSTGG.iSTDRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2012|    2039|       4
---------------------------------------------------------------------------
 2012- 2039 (37.05/34.07)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2042- 2070 (44.88/29.69)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.11|      51|     480|     985|    1038|       5
---------------------------------------------------------------------------
  985- 1038 (86.22/44.77)	PatPRFSVPtPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNS
 1470- 1520 (93.89/41.40)	P..PKYQTP.PAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.20|      29|    1265|     333|     361|       6
---------------------------------------------------------------------------
  333-  361 (53.61/34.99)	TQSKRSQMST.PTLEEEPASNPATWDF.VDP
 1598- 1628 (44.59/27.49)	TERERIGIPTePDSADSHAHPPAVVIYmVDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.82|      26|      28|    1802|    1828|       7
---------------------------------------------------------------------------
 1802- 1828 (42.51/34.20)	IALPSRSRRSkVSAR..KIGLQKLWEWCI
 1831- 1858 (43.32/29.64)	VQMTSLPWRV.VIGRlgRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.04|      23|      26|    1684|    1709|       8
---------------------------------------------------------------------------
 1687- 1709 (44.77/36.88)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1711- 1738 (30.27/13.78)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      12|     299|      71|      82|       9
---------------------------------------------------------------------------
   71-   82 (23.47/13.07)	HNLLERCLMDKN
  372-  383 (23.32/12.94)	HKLLKRCAVGPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      24|    1641|    1660|      10
---------------------------------------------------------------------------
 1641- 1660 (31.05/26.04)	NFWLLSLMRCyTEMLDNLPE
 1664- 1682 (34.81/23.11)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.71|      19|     395|     295|     313|      13
---------------------------------------------------------------------------
  295-  313 (36.36/20.09)	SQDG.GMITMHSPKRSGKIP
  691-  710 (31.35/16.22)	SEDGfGTKDVTTPGHSTPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.28|      11|      24|    1974|    1985|      15
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 1974- 1985 (17.73/12.82)	PFPDDmDNDIGI
 2001- 2011 (21.55/10.28)	PSPGS.PSGIGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19051 with Med13 domain of Kingdom Metazoa
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