<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19042
Description |
Mediator complex subunit 14 |
Sequence | MVDFSGQIVAFTTPGGGGGRESGKGKAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSVHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1454 |
Position | Tail |
Organism | Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Colobinae> Rhinopithecus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.186 |
Instability index | 51.14 |
Isoelectric point | 9.03 |
Molecular weight | 160735.81 |
Publications | PubMed=25362486
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP19042
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 83.03| 24| 30| 1326| 1351| 1
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1326- 1351 (43.68/29.42) PdqATQLKWNVQFC..LTIPPSAPPIAP
1355- 1380 (39.36/20.24) P..AVVLKSKMLFFlqLTQKTSVPPQEP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.19| 29| 30| 69| 97| 2
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69- 97 (46.39/39.11) LTDLLPRKSDVERKIEIVQFASRTRQLFV
102- 130 (48.79/41.59) LVKWANNAGKVEKCAMISSFLDQQAILFV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 77.08| 24| 29| 252| 280| 3
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252- 275 (40.30/35.35) ILVEDKETGDGRALVH....SMQISFIH
282- 309 (36.78/19.49) LFADEKPLQDMYNCLHsfclSLQLEVLH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 247.72| 59| 66| 1013| 1077| 4
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1013- 1069 (104.18/49.63) .........PGTSGAYPL.TSP.PTSYHS....TVNQS.PSMM..HTQSPGNLHAASSPSGALRAP..SPASFVPTP
1071- 1131 (74.92/41.76) PSshgisigPGASFASPHgTLD.PSSPYT....MV..S.PSGR..AGNWPGS.PQVSGPSPAARMPgmSPAN.....
1132- 1190 (68.63/28.43) PS...............L.HSPvPDASHSpragTSSQTmPTNMppPRKLPQRSWAASIPTILTHSA..LNILLLPSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 37.33| 10| 24| 1402| 1411| 5
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1402- 1411 (17.56/10.65) PRQQNSSVAA
1428- 1437 (19.77/13.02) PRQGECTIFA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 155.09| 51| 508| 329| 379| 6
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329- 379 (92.74/64.94) YHAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP
812- 878 (62.35/40.97) YGTTKGSSISIqWNsvhQKfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.49| 14| 29| 168| 181| 7
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168- 181 (26.30/14.06) RLPTCIRDKII....PPD
194- 211 (19.19/ 8.15) QLNQILRHRLVttdlPPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.60| 14| 36| 1247| 1261| 11
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1247- 1261 (21.47/17.29) LKCRVALSP.KTNqTL
1285- 1299 (22.14/12.18) FETRVAGPPfKAN.TL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 87.55| 28| 34| 509| 540| 13
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509- 540 (41.94/33.55) IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
542- 571 (45.60/25.97) LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
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