Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLLPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1582 |
Position | Middle |
Organism | Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.676 |
Instability index | 54.33 |
Isoelectric point | 8.89 |
Molecular weight | 168524.19 |
Publications | PubMed=25362486 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl nucleolus GO:0005730 IEA:Ensembl nucleoplasm GO:0005654 IEA:Ensembl |
GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 IEA:Ensembl peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 IEA:Ensembl transcription corepressor activity GO:0003714 IEA:Ensembl vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl angiogenesis GO:0001525 IEA:Ensembl animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 IEA:Ensembl cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl keratinocyte differentiation GO:0030216 IEA:Ensembl lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 IEA:Ensembl liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 IEA:Ensembl monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl negative regulation of apoptotic process GO:0043066 IEA:Ensembl negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl negative regulation of neuron differentiation GO:0045665 IEA:Ensembl negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 IEA:Ensembl positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl protein import into nucleus GO:0006606 IEA:Ensembl regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats | >MDP19037 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 7| 381.57| 50| 50| 1083| 1132| 1 --------------------------------------------------------------------------- 983- 1033 (51.70/10.87) LAG........PGLDSKPGKR....SRTPSNDG.......KSKDKP..PKRKKA...DTEGK...SP.SHSSSnrpfTP 1034- 1082 (44.24/ 8.18) PTS........TG.....GSK.SPGSSGRSQTP.......PGVATPpiPKITIQ...IPKGT..vMV.GKPSS...hSQ 1083- 1132 (88.88/24.25) YTS........SGSVSSSGSK.SHHSHSSSSSS.......SSASTS..GKMKSS...KSEGS...SS.SKLSS....SM 1133- 1183 (54.12/11.74) YSS........QGSSGSSQSKnSSQSGGKPGSSpitkhglSSGSSS..TKM......KPQG........KPSS....LM 1186- 1226 (48.38/ 9.67) SLS........KPNISPS......HSRPPGGSD.......KLASP.....MKPV.....PGT..pPS.SKAKS....PI 1268- 1315 (50.68/10.50) TAS........SSSFSSSGS..SM....SSSQN.......QHGSSK..GKSPSR...NKKPSltaVI.DKLKH....GV 1316- 1377 (43.57/ 7.94) VTSgpggedplDGQMGVSTNS.SSHPMSSKHNM.......SGGEFQ..GKREKSdkdKSKVS...TSgSSVDS....SK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 173.19| 43| 48| 1397| 1442| 2 --------------------------------------------------------------------------- 1397- 1427 (48.07/16.66) ..............KH.................DGGSPSIKAKVTLQKPGE......SSGEGLRPQMA 1431- 1460 (52.77/22.74) NYGSPLISGST..PKH.................ERGSPS...........H......SKSPAYTPQ.. 1461- 1489 (37.55/ 8.80) NLDSESESGSSiaEKS.................YQNSPS...................SDDGIRP... 1490- 1548 (34.81/ 9.48) .....LPEYST..EKHkkhkkekkkvkdkdrdrDRDKDRDKKKSHSIKPESwskspiSSDQSL..SMT --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 448.01| 108| 117| 535| 651| 3 --------------------------------------------------------------------------- 535- 619 (138.21/56.42) .............................MVKKNLP.PAS..SPGYGMT.TGNNPMSGTTT.PTNTFP...GGPITTLFNM.SMSI.....KDRHESVGHGEDFS.KV.SQNP.ILTSLLQITGNGGSTIG 625- 735 (119.57/62.79) PHHTPPPVSSMAGNTKNHpmLMNllKD.........nPAQdfSTLYGSS.PLERQNSSSGS.PRMEIC...SGSNKTKKKK.SSRLlpekpKHQTEDDFQRELFSmDVdSQNP.IF.D.VNMTADTLDT.. 736- 804 (85.02/29.57) PHITPAP.SQCS.................................................tPPTTYPqpvPHPQPSIQRMvRLSS.....SD...SI..GPDVT.DIlSDIA.EEASKLPSTSDDGPAIG 805- 884 (105.20/41.25) ...TPLRDSSSSGHSQST..LFD..SDvfQTNNNEN.PYT..DPADLIAdAAGSPSS..DS.PTNHF..............................FHDGVDF.......NPdLLNSQSQ.SGFGEEYFD --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 208.08| 48| 48| 146| 193| 4 --------------------------------------------------------------------------- 146- 193 (81.59/36.92) NFD.EFSKHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQ.DLSKMAIMYWK 196- 244 (70.55/31.08) NAG.PLDKILHGSVG.YLT..........PrsGGHLMNLKYYVSPSDLLD.DKTASPIILHE 250- 306 (55.94/23.35) SLGmNASVTIEGTSAMYKLpiaplimgshP..VDNKW.TPSFSSITSANSvDLP..ACFFLK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.23| 17| 46| 308| 324| 5 --------------------------------------------------------------------------- 308- 324 (31.84/17.88) PQPIPVSRA..FVQKL...QSC 352- 373 (24.39/12.01) PDPIPLNHNmrFYAALpgqQHC --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.93| 13| 51| 907| 919| 6 --------------------------------------------------------------------------- 907- 919 (24.99/13.98) GVPMLGGDNGESK 942- 954 (20.94/10.24) GPADLMEHHSGSQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 182.72| 48| 55| 376| 424| 7 --------------------------------------------------------------------------- 376- 421 (71.89/39.99) .......LNKDAP..LP.DGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLI 423- 475 (60.79/34.37) SCvkrtiLKEDSPglLQfEVCPLSESRFS.VSFQHPVNDSLV..CVVMDVQDSTHV 476- 514 (50.03/22.85) SC....kLYKG....LS.DALICTDDFIAKVV.QRCMSIPVTMRAIRRK....... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.14| 13| 35| 891| 903| 8 --------------------------------------------------------------------------- 891- 903 (23.80/16.88) DNDDFK..GFASQAL 927- 941 (17.34/ 9.92) DTVDFSiiSVAGKAL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) IRPLPEYSTEKHKKHKKEKKKVKDKDRD 3) KITIQIPK 4) KPSLTAVIDKLKHGV 5) RLSPDFMIGEEDDDLMDV 6) SIKAKVTLQK 7) VAKIIISKH | 878 1487 1062 1301 1560 1404 1390 | 884 1514 1069 1315 1577 1413 1398 |
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