<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19037
| Description |
Mediator of RNA polymerase II transcription subunit 1 |
| Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLLPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN |
| Length | 1582 |
| Position | Middle |
| Organism | Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Colobinae> Rhinopithecus.
|
| Aromaticity | 0.04 |
| Grand average of hydropathy | -0.676 |
| Instability index | 54.33 |
| Isoelectric point | 8.89 |
| Molecular weight | 168524.19 |
| Publications | PubMed=25362486
|
Function
| Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
|
| GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleolus GO:0005730 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
| GO - Biological Function | DNA binding GO:0003677 IEA:Ensembl
estrogen receptor binding GO:0030331 IEA:Ensembl
LBD domain binding GO:0050693 IEA:Ensembl
nuclear receptor coactivator activity GO:0030374 IEA:Ensembl
peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl
promoter-specific chromatin binding GO:1990841 IEA:Ensembl
protein-containing complex binding GO:0044877 IEA:Ensembl
retinoic acid receptor binding GO:0042974 IEA:Ensembl
thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription corepressor activity GO:0003714 IEA:Ensembl
vitamin D receptor binding GO:0042809 IEA:Ensembl
|
| GO - Biological Process | androgen biosynthetic process GO:0006702 IEA:Ensembl
angiogenesis GO:0001525 IEA:Ensembl
animal organ regeneration GO:0031100 IEA:Ensembl
brain development GO:0007420 IEA:Ensembl
cell morphogenesis GO:0000902 IEA:Ensembl
cellular response to epidermal growth factor stimulus GO:0071364 IEA:Ensembl
cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl
cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl
embryonic heart tube development GO:0035050 IEA:Ensembl
embryonic hemopoiesis GO:0035162 IEA:Ensembl
embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl
embryonic placenta development GO:0001892 IEA:Ensembl
enucleate erythrocyte development GO:0048822 IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl
fat cell differentiation GO:0045444 IEA:Ensembl
intracellular steroid hormone receptor signaling pathway GO:0030518 IEA:Ensembl
keratinocyte differentiation GO:0030216 IEA:Ensembl
lactation GO:0007595 IEA:Ensembl
lens development in camera-type eye GO:0002088 IEA:Ensembl
liver development GO:0001889 IEA:Ensembl
mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl
mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl
megakaryocyte development GO:0035855 IEA:Ensembl
monocyte differentiation GO:0030224 IEA:Ensembl
mRNA transcription by RNA polymerase II GO:0042789 IEA:Ensembl
negative regulation of apoptotic process GO:0043066 IEA:Ensembl
negative regulation of keratinocyte proliferation GO:0010839 IEA:Ensembl
negative regulation of neuron differentiation GO:0045665 IEA:Ensembl
negative regulation of transcription by RNA polymerase II GO:0000122 IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl
positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl
positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl
positive regulation of gene expression GO:0010628 IEA:Ensembl
positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl
positive regulation of keratinocyte differentiation GO:0045618 IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
protein import into nucleus GO:0006606 IEA:Ensembl
regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl
retinal pigment epithelium development GO:0003406 IEA:Ensembl
thyroid hormone generation GO:0006590 IEA:Ensembl
thyroid hormone mediated signaling pathway GO:0002154 IEA:Ensembl
ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl
|
Interaction
Repeat regions
| Repeats |
>MDP19037
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
7| 381.57| 50| 50| 1083| 1132| 1
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983- 1033 (51.70/10.87) LAG........PGLDSKPGKR....SRTPSNDG.......KSKDKP..PKRKKA...DTEGK...SP.SHSSSnrpfTP
1034- 1082 (44.24/ 8.18) PTS........TG.....GSK.SPGSSGRSQTP.......PGVATPpiPKITIQ...IPKGT..vMV.GKPSS...hSQ
1083- 1132 (88.88/24.25) YTS........SGSVSSSGSK.SHHSHSSSSSS.......SSASTS..GKMKSS...KSEGS...SS.SKLSS....SM
1133- 1183 (54.12/11.74) YSS........QGSSGSSQSKnSSQSGGKPGSSpitkhglSSGSSS..TKM......KPQG........KPSS....LM
1186- 1226 (48.38/ 9.67) SLS........KPNISPS......HSRPPGGSD.......KLASP.....MKPV.....PGT..pPS.SKAKS....PI
1268- 1315 (50.68/10.50) TAS........SSSFSSSGS..SM....SSSQN.......QHGSSK..GKSPSR...NKKPSltaVI.DKLKH....GV
1316- 1377 (43.57/ 7.94) VTSgpggedplDGQMGVSTNS.SSHPMSSKHNM.......SGGEFQ..GKREKSdkdKSKVS...TSgSSVDS....SK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 173.19| 43| 48| 1397| 1442| 2
---------------------------------------------------------------------------
1397- 1427 (48.07/16.66) ..............KH.................DGGSPSIKAKVTLQKPGE......SSGEGLRPQMA
1431- 1460 (52.77/22.74) NYGSPLISGST..PKH.................ERGSPS...........H......SKSPAYTPQ..
1461- 1489 (37.55/ 8.80) NLDSESESGSSiaEKS.................YQNSPS...................SDDGIRP...
1490- 1548 (34.81/ 9.48) .....LPEYST..EKHkkhkkekkkvkdkdrdrDRDKDRDKKKSHSIKPESwskspiSSDQSL..SMT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 448.01| 108| 117| 535| 651| 3
---------------------------------------------------------------------------
535- 619 (138.21/56.42) .............................MVKKNLP.PAS..SPGYGMT.TGNNPMSGTTT.PTNTFP...GGPITTLFNM.SMSI.....KDRHESVGHGEDFS.KV.SQNP.ILTSLLQITGNGGSTIG
625- 735 (119.57/62.79) PHHTPPPVSSMAGNTKNHpmLMNllKD.........nPAQdfSTLYGSS.PLERQNSSSGS.PRMEIC...SGSNKTKKKK.SSRLlpekpKHQTEDDFQRELFSmDVdSQNP.IF.D.VNMTADTLDT..
736- 804 (85.02/29.57) PHITPAP.SQCS.................................................tPPTTYPqpvPHPQPSIQRMvRLSS.....SD...SI..GPDVT.DIlSDIA.EEASKLPSTSDDGPAIG
805- 884 (105.20/41.25) ...TPLRDSSSSGHSQST..LFD..SDvfQTNNNEN.PYT..DPADLIAdAAGSPSS..DS.PTNHF..............................FHDGVDF.......NPdLLNSQSQ.SGFGEEYFD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 208.08| 48| 48| 146| 193| 4
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146- 193 (81.59/36.92) NFD.EFSKHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQ.DLSKMAIMYWK
196- 244 (70.55/31.08) NAG.PLDKILHGSVG.YLT..........PrsGGHLMNLKYYVSPSDLLD.DKTASPIILHE
250- 306 (55.94/23.35) SLGmNASVTIEGTSAMYKLpiaplimgshP..VDNKW.TPSFSSITSANSvDLP..ACFFLK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 56.23| 17| 46| 308| 324| 5
---------------------------------------------------------------------------
308- 324 (31.84/17.88) PQPIPVSRA..FVQKL...QSC
352- 373 (24.39/12.01) PDPIPLNHNmrFYAALpgqQHC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.93| 13| 51| 907| 919| 6
---------------------------------------------------------------------------
907- 919 (24.99/13.98) GVPMLGGDNGESK
942- 954 (20.94/10.24) GPADLMEHHSGSQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 182.72| 48| 55| 376| 424| 7
---------------------------------------------------------------------------
376- 421 (71.89/39.99) .......LNKDAP..LP.DGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLI
423- 475 (60.79/34.37) SCvkrtiLKEDSPglLQfEVCPLSESRFS.VSFQHPVNDSLV..CVVMDVQDSTHV
476- 514 (50.03/22.85) SC....kLYKG....LS.DALICTDDFIAKVV.QRCMSIPVTMRAIRRK.......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.14| 13| 35| 891| 903| 8
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891- 903 (23.80/16.88) DNDDFK..GFASQAL
927- 941 (17.34/ 9.92) DTVDFSiiSVAGKAL
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|
