<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19002

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHNKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALPGPWPQLILGVRALGPSDGLTHLCPTVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length744
PositionTail
OrganismRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.03
Grand average of hydropathy-0.652
Instability index82.67
Isoelectric point9.42
Molecular weight82342.08
Publications
PubMed=25362486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP19002
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     334.95|      40|      40|     143|     182|       1
---------------------------------------------------------------------------
  171-  213 (58.02/10.12)	QQQQ.QQQFQAQQ.......saMQQQfQAV.VQQQ....QQQLQQQQQQQ...QHLIKL
  214-  254 (65.34/12.51)	HHQN.QQQIQQQQ.........QQLQ.RMAqLQLQ....QQQQQQQQQQQ...QALQAQ
  263-  300 (70.22/14.10)	QQPQ.PPPTQALP.........QQLQ.Q...MHHP....QHHQPPPQPQQ...PPVAQN
  301-  342 (46.28/ 6.29)	QPSQlPPQSQTQP.........LVSQ.AQA.LPGQmlytQPPLKF...VR...APMVVQ
  343-  379 (46.26/ 6.29)	QPPV.QPQVQ...............Q.QTA.VQTA....QAAQMVAPGVQmitEALAQG
  380-  428 (48.83/ 7.13)	GMHI.RARFPPTTavsavpsssIPLG.RQP.MAQV....QTPQSMPPPPQ...PSPQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.95|      18|      21|      76|      96|       2
---------------------------------------------------------------------------
   76-   93 (35.49/12.96)	QSLTGGPAAGAAGIGMPP
   98-  113 (25.91/11.34)	QSLGGMGSLGAMGQPM..
  115-  128 (23.55/ 7.47)	..LSGQPPPGTS..GMAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.17|      16|     139|     454|     471|       3
---------------------------------------------------------------------------
  454-  471 (26.86/23.64)	RalGPS........DGLTHLCPTVNP
  478-  501 (20.30/10.66)	A..GSSqaeeqqylDKLKQLSKYIEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     192.11|      46|     112|     550|     596|       4
---------------------------------------------------------------------------
  550-  596 (81.36/42.41)	KLkNDMAVPTPP.P............PPVPPTKQ.QYLCQPLLDAVLANIRSPVF....NHSLYR
  601-  640 (58.59/25.93)	AM...TAIHGPPiT............APVVCTRK.R....RLEDDERQSIPS.VL....QGEVAR
  665-  724 (52.16/22.25)	KL.DDKDLPSVP.PlelsvpadypaqSPLWIDRQwQYDANPFLQSVHRCMTSRLLqlpdKHS...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.56|      14|      15|     140|     153|       5
---------------------------------------------------------------------------
  140-  153 (25.78/10.05)	QTQL.QLQQVALQQQ
  156-  170 (22.78/ 7.86)	QQQFqQQQQAALQQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19002 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) GLTHLCPTVNPSSVMSPAGSSQAEEQQYLD
3) MLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALPG
4) QQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
74
461
325
245
138
490
444
323










Molecular Recognition Features






MoRF SequenceStartStop




NANANA