<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP19001

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHNKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length673
PositionTail
OrganismRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.04
Grand average of hydropathy-0.798
Instability index92.25
Isoelectric point9.38
Molecular weight75438.68
Publications
PubMed=25362486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP19001
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.16|      32|      34|     136|     168|       2
---------------------------------------------------------------------------
  136-  168 (59.10/14.89)	QQQLQQQQQQQQHLIKlHHQNQQQIQQ...QQQQLQ
  177-  207 (48.47/ 8.83)	QQQQQQQQQQQQAL.....QAQPPIQQppmQQPQPP
  209-  239 (54.59/11.18)	TQALPQQLQQMHH.PQ.HHQPPPQPQQ...PPVAQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     227.52|      36|      36|     335|     370|       3
---------------------------------------------------------------------------
  240-  284 (47.75/12.93)	QP..SQLPPQSQT...QP........LV.SQAQ..AlpgqmlytQ.PPL...KFV.RAPMvvqQPP
  286-  319 (36.50/ 7.69)	QPqvQQQTAVQTA...QA......AQMV.APGV..Q........V.SQS...S.L.PMLS......
  338-  371 (68.17/22.43)	QP..SPQPGQPGS...QP......NSNV.SSGP..A........P.SPS...SFL.PSPS.....P
  372-  409 (35.40/ 7.18)	QP..SQSPVTART...PQ......NFSVpSPGPlnT........PvNPS...SVMsPAGS......
  490-  538 (39.70/ 9.18)	PP..PPVPPTKQQylcQPlldavlANIR.SP....V........F.NHSlyrTFV.PAMTaihGPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.83|      18|      42|      75|      92|       4
---------------------------------------------------------------------------
   75-   92 (28.40/10.05)	QASVSAQLQLQQVALQQQ
  118-  135 (29.43/10.68)	QAQQSAMQQQFQAVVQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.42|      30|     150|     433|     467|       5
---------------------------------------------------------------------------
  433-  467 (47.90/33.84)	RMINKIDknedrKKDLSKMKSL.LDILTDPSKRCPL
  590-  620 (47.52/23.89)	HLICKLD.....DKDLPSVPPLeLSVPADYPAQSPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP19001 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
184
423










Molecular Recognition Features






MoRF SequenceStartStop




1) LKFVRA
271
276