<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18990

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDHSSPHKEVINTTEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAIEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGLCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFSKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLYPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2087
PositionMiddle
OrganismRhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.405
Instability index53.27
Isoelectric point5.38
Molecular weight229305.98
Publications
PubMed=25362486

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18990
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.50|      42|      61|     376|     419|       1
---------------------------------------------------------------------------
  376-  419 (69.10/41.09)	EKSEKPQKRPLTPfhHRVSVSDDVGMDTDSA..SQRLV.ISAPDSQV
  439-  483 (73.40/37.78)	EMANSPQPPPLSP..HPCDVVDEGVTKTPSTpqSQHFYqMPTPDPLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.04|      40|     846|     990|    1044|       2
---------------------------------------------------------------------------
  991- 1036 (67.81/63.62)	SESVMNLFK...DCNFDSCCIcvcnmNIKGADVgVYIPDP.TQEAQYRCT
 1526- 1569 (65.23/27.04)	SESTMDRDKvgiPTDGDSHAI.....TYPPAIV.VYIIDPfTYENTDEST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.78|      13|      35|    1165|    1177|       3
---------------------------------------------------------------------------
 1165- 1177 (24.74/15.87)	DEALVKSSCLYPW
 1203- 1215 (24.04/15.19)	QDAIQKKRTVRPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.32|      56|      68|     837|     901|       4
---------------------------------------------------------------------------
  837-  893 (99.14/70.77)	PSQYLPPIkLPEECIYR.QSWTVGKLELLSSGSAMPFIKEGDGSNMDQE.YGPAYTPQT
  906-  963 (93.19/46.82)	PSNSGAGI.LPSPSTPRfPTPRTPRTPRTPRGAGGPASAQGSVKYENSDlYSPASTPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     477.90|     132|     482|     164|     341|       5
---------------------------------------------------------------------------
  175-  312 (208.23/120.50)	DDSLAAVEVLVAGV..RMIYPAcfVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQ.SAQKWVKF...........SSVSDGFNSDSTSHHGGKipRKLANHVVDRVwqECNMNRAQNKRKYSASS
  645-  739 (137.79/53.18)	.................................TSSVTVLSHEEDAMSLFSP.SIKQDAPRPASHARPPSTSLIYDSDLA........VSF...........TDLDNLFNSDEDELTPGS..KKSANGSDDKA..SCKESKTGNLDPLSCIS
 1383- 1500 (131.88/49.70)	DSSLLSQPNLVAPTsqSLITPP..QMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGvSSNKLPSFppfgsmnsnaaGSMSTQANTVQSGQLGGQ................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     251.25|      77|     482|     742|     823|       6
---------------------------------------------------------------------------
  742-  823 (131.18/83.09)	DLHKM.....YPTPPSLEQHIMgfsPMNMNNKEYGSMDTTPGG......TVLE..GNSSSIGAQFKIEVDEGLCSPKPSEIKDFSYVYkpENCQI
 1225- 1314 (120.08/64.25)	QFHKMagrgsYGTDESPEPLPI...PTFLLGYDYDYLVLSPFAlpywerLMLEpyGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIY..ESCRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.89|      96|    1060|     539|     641|       7
---------------------------------------------------------------------------
  539-  641 (155.58/117.32)	VEFLPPQLPS...............DKFKDDPVGPfgQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPK.IDPYAfvegdEEFLFPDKKDRQN..SER..EAGKKHKV
 1587- 1702 (145.32/92.71)	VQTLPPHIKStvsvqiipcqyllqpVKHEDREIYP..QHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPEcIRLYA.....PPFILAPVKDKQTelGETfgEAGQKYNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.83|      45|     990|     103|     159|       8
---------------------------------------------------------------------------
  103-  159 (70.43/68.83)	LSEEHITLAQQSNSPfqvILCPFGLNGtltgqafkmSDSATKK.LIGEWKQFYPISCC
 1097- 1142 (77.41/48.24)	LSDDLILLLQDQCTN...LFSPFGAAD.........QDPFSKSgVISNWVRVEERDCC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      14|      28|    1037|    1052|      10
---------------------------------------------------------------------------
 1037- 1052 (21.97/19.65)	CGFSAimNRKFGNSSG
 1068- 1081 (25.31/14.94)	CGKEA..EKRFEALRG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18990 with Med13 domain of Kingdom Metazoa
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