<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18961
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MAASSSGEKEKERLGGGLGVASGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQVGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD |
Length | 270 |
Position | Middle |
Organism | Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Colobinae> Rhinopithecus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.613 |
Instability index | 49.42 |
Isoelectric point | 5.02 |
Molecular weight | 29803.17 |
Publications | PubMed=25362486
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl
nucleoplasm GO:0005654 IEA:Ensembl
|
GO - Biological Function | thyroid hormone receptor binding GO:0046966 IEA:Ensembl
transcription coactivator activity GO:0003713 IEA:Ensembl
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
transcription by RNA polymerase II GO:0006366 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP18961
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 91.62| 27| 28| 58| 84| 1
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37- 52 (15.88/ 7.98) ........LEVL..SR..ELIEMLAISR
58- 84 (45.34/36.80) QVGEENQVLELLI.HRDGEFQELMKLAL
88- 112 (30.40/22.19) KIHHEMQVLEKEVeKRDSDIQQLQK...
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.07| 23| 23| 216| 238| 2
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216- 238 (44.66/31.64) LAPQYPWQSNDMSMNMLPPNHSS
242- 264 (39.42/27.05) LEPPGHNKENEDDVEIMSTDSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 44.53| 13| 15| 6| 18| 3
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6- 18 (22.82/12.53) SGEKEKERLGGGL
22- 34 (21.71/11.64) SGNSTRERLLSAL
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