<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18928

Description Mediator of RNA polymerase II transcription subunit 13
SequenceEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDDLGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTMSQPGFSAGPSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDAPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPLNPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPQMQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRPSKIPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTRKPQEPPISLLLLLQNQHTQPFASLSFLDYISSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSTTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISTDRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2050
PositionMiddle
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index59.57
Isoelectric point5.65
Molecular weight224291.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18928
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     500.73|     107|     112|     660|     766|       1
---------------------------------------------------------------------------
  366-  452 (110.42/48.67)	...............DKQMAV.PSRN.TSKQMNLNPMD.SP.........HSPISPLP.PTLSPQPRGQETesldPPS.....VPVNPAL.....Y.GN..GLEL.QQLSTLD....DRTVL......VGQRLPLMAEV
  454-  573 (124.80/56.11)	ETALYCGIRPLNPesSEKWWHSYRLP.PSD....DAEF.RPpelQGErcDAKMEVNSE.STA..LQRLLAQ....PNKrfkiwQDKQPQMQP.LHF.LDplPLSQ.QPGDSLG...EVNDPYtfedgdIKYIFTANKKC
  660-  753 (144.85/66.48)	...............DELGAVSPALR.PSKIPTVGTED.RP...LGK..DGRAAVPYP.PTVADLQRMFPT....PPS.....LEQHPAFSPVMNY.KD..GISS.ETVTALG...MMESPM......VSMVSTQLTEF
  754-  859 (120.66/53.97)	KMEVEDGLGSPKP..EEIKDFSYVHKvPSFQPFVGSSMfAP...LKM.lPSHCLLPLKiPDACLFRPSWAI....PPK.....IEQLP.MPPAATFiRD..GYNNvPSVGSLAdpdYLNTPQ......MN.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     492.38|     168|    1266|       3|     257|       2
---------------------------------------------------------------------------
   61-  244 (263.89/216.20)	TGQAYKMSDPATRKLieEWQYFYPMVLK...KKEESKEEDDLGYDDDFPVAVEVIVGgvrmVYPSAFVLISQNDIPVPQS..VASAGGHITV......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GQQGLGSVKDPSN.CGMPLTPPTSPEQAILGESGGMQSAASHLVsQDGGMITMHsPKRSGKIPPKLHNhMVHRVWKECILNrTQSkrSQMSTPtleeE
 1183- 1255 (77.34/13.74)	TGRTWENIQHVQGPL..TWQQFHKMAGRgtyGSEESPEP........LPIPT.LLVG.....YDKDFLTISPFSLPFWERllLDPYGGH...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1742- 1829 (112.68/35.22)	............................................................................................rdvayivvcpeneallegaktffrdlsavyemcrlgqhkpickvlrdgimrvgktvaqkltdelvsewfnqpwsgeendnhsrlklyaqvcrhhlapylatlqldssllippkyqtppaaaqgqatpgnagplapngsaappagsafnptsnssttnpaasssasgssvppvsssasapgisqisttsssgfsgsvggqnpstggistdrtqgnigcggdtdpgqsssqpsqdgqesvtererigiptepdsadshahppavviymvdpftyaaeedstsgnfwllslmrcytemldnlpehmrnsfilqivpcqymlqtmkdeqvfyiqylksmafsvycqcrrplptqihiksltgfgpaasiemtlknperpspiqlysppfilapikdkqtelgetfgeasqkynvlfvgyclshdqrwllasctdlhgelletcvvnialpsrsrrskvsarkiglqklwewcigivqmtslpwrvvigrlGRLGHGELKDWSIlLGECSLQTISKKLKDVCRMCGISAADSPSI.LSACLVAME.PQGSFVVMPDAVT.MGSVFGRSTALN.MQS..SQLNTP....Q
 1859- 1908 (38.47/23.72)	...................................SPNNDDMFVDLPFPDDMDNDIG....ILMTGNLHSSPNSSPVP.S..PGSPSG.IGV......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................G.................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.15|      26|    1266|       3|      29|       3
---------------------------------------------------------------------------
    3-   29 (45.39/37.43)	LSCAFTFFlHGESNVCTSVEIAQHQPI
 1271- 1296 (48.77/35.17)	LEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     348.70|      64|     480|     881|     948|       4
---------------------------------------------------------------------------
  249-  298 (67.24/25.12)	......PATWDFVDPT....QRvscsCS..........RHKLLKRCAvGPNRP.......PTMSQ...........PGFSAGPSSSSS
  598-  636 (48.40/15.56)	..........................................TPGHS.TPV.PDGKN....AMSIFSSATKTDVRQD.NAAGRAGSSS
  878-  942 (110.88/48.05)	LP...sPATPRFSVPT....PR....TP..........RTPRTPRGG.GTASGQGSVK.YDSTDQGSPASTPSTTRPLNSVEPATMQP
 1366- 1423 (90.61/36.96)	......P..PKYQTP.....PA....AA..........QGQATPGNA.GPLAPNGSAA.PPAGSAFNPTSNSSTTNPAAS.SSASGSS
 1424- 1486 (31.58/14.16)	VPpvssSA....SAPGisqiST....TSssgfsgsvggQNPST..GGiSTDRTQGNIGcGGDTDPGQSSSQPS...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.91|      46|     623|    1300|    1350|       5
---------------------------------------------------------------------------
 1300- 1350 (68.05/59.93)	LRDGIMRVGKTVAQKLTDELvSEWFnqpWSG.EENDNHSRLKLYAQVcRHHL
 1930- 1976 (80.85/50.92)	LKQQPLALGYFVSTAKAENL.PQWF...WSScPQAQNQCPLFLKASL.HHHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.04|      23|      26|    1580|    1605|       8
---------------------------------------------------------------------------
 1583- 1605 (44.77/28.12)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1607- 1634 (30.27/10.34)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.65|      17|    1582|     327|     344|      10
---------------------------------------------------------------------------
  327-  344 (27.87/23.01)	FHHRPSVAEELcMEQDAP
 1911- 1927 (30.78/18.90)	FQHSRSQGERL.LSREAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.72|      18|      26|    1689|    1706|      11
---------------------------------------------------------------------------
 1689- 1706 (29.91/15.78)	ELLETCVVNIALPSRSRR
 1718- 1735 (36.81/21.06)	KLWEWCIGIVQMTSLPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.86|      19|      25|    1537|    1556|      12
---------------------------------------------------------------------------
 1537- 1556 (31.05/25.63)	NFWLLSLMRCyTEMLDNLPE
 1560- 1578 (34.81/22.76)	NSFILQIVPC.QYMLQTMKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18928 with Med13 domain of Kingdom Metazoa
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