<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18926

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTGSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQKQCSPSSPCFPGKACSRPSSSSRRPPWCGSSRSSFQATSHSKE
Length2107
PositionKinase
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.410
Instability index57.75
Isoelectric point8.13
Molecular weight235510.84
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18926
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     528.91|     174|     203|     874|    1074|       1
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  874- 1070 (278.09/217.63)	SYTTGLCVCIVAVLRRyhsclilnpdqtaQVFeGLCGVVKHVVNPS.........ECSSPER..C.ILAYLYDLYVSCsHLRSKFGDLFS...SACSKVKQTIYNNVMPANSNLRWDPDFMM..DF.IENPSARSI...NYSMLGKILSDNAANRYSFVCNTlmNVCmGHQDAGRINDIANFSSE.LTACCtvlSSEWLG..VLKA...LCCSSNHVwgFNDVL
 1079- 1279 (250.82/141.64)	SFHDSLATFIAILIAR.............QCF.SLEDVVQHVALPSllaaacgdaDAEPGARmtCrLLLHLFRAPQAC.FLPQATGKPFPgirSSCDRHLLAAAHNSIEVGAVFAVLKAIMMlgDAkIGNNSVSSLkndDFTMRGLRCDGNADDIWTASQNP..KSC.GKSISIETANLREYARYvLRTIC...QQEWVGehCLKEperLCTDKELI..LDPVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     697.54|     169|     203|    1638|    1813|       2
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 1465- 1632 (204.57/105.64)	QPFLSLVLT...CLKGQD..EQREG..LL......TSLQNQVnqilSNWReeryqddikarqmMHEALQLRLNLVGG................MFDTV...QRSTQWTTDWALLLLQiitsgTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKR....SESID........KV.........RQLLPL...PKQTC.
 1639- 1812 (268.83/160.04)	.PMGSLIDTKGnKIAGFDSIDKKQG..LQ......VSTKQKV....SPWD.............LFEGQKNPAPLSWA................WFGTVRVDRRVIKYEEQHHLLLYH.....THPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEypQSniyRVPPNYSPIS.SQMMHH...PQSTLW
 1840- 2024 (224.15/112.49)	DPAGSFVPTNT.KQALSNMLQRRSGamMQppslhaITSQQQL....IQMK.............LLQQQQQQRLLRQAqtrpfqqgqpgdqaalFAAQARPSPQLPQYPG.....LQQ.....AQTMPQGYTMYGTQMPL..QQTSQQQAGSVVLSPSYNSRAYPAAHSNPVLMERL...RQIQQQPSGYVQQ..QA.....SPYLQPLTgSQRLNHqalQQSPLV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.10|      18|     251|     554|     584|       5
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  566-  584 (27.42/10.15)	LPVFQNVLLRFlDTQAPSL
  824-  841 (32.68/14.29)	LPLAHHIQLIF.DLMEPAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.47|      12|     251|     408|     419|       6
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  408-  419 (25.34/15.51)	PMPG.....GNTAFNQQ
  660-  676 (18.13/ 8.76)	PMPGescenANTSLGRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.94|      54|    1056|     308|     369|      10
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  308-  369 (90.59/75.80)	DSPNLLAAHSPHM.MIGPNnsSIGAPSPGppgpgmSPVQLAFSDFLSCAQH......GPLVYGLSCMLQ
 1366- 1426 (82.35/49.32)	QSADLNNSSNSGMsLFNPN..SIGSADTG......STRQNGIKTFLSSSERrgvwlvAPLIARLPTSVQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18926 with Med12 domain of Kingdom Metazoa
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