<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18922

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2055
PositionKinase
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.416
Instability index52.21
Isoelectric point6.48
Molecular weight228378.07
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18922
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.06|      16|      17|     638|     654|       1
---------------------------------------------------------------------------
  643-  661 (22.94/10.08)	DPEHKEAEGSSSsklEDPG
 1758- 1773 (30.12/11.35)	EPEKKAPEPPKT...DKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     853|     867|       2
---------------------------------------------------------------------------
  853-  867 (26.85/21.84)	LEQITSFALG.MSYHL
  869-  884 (23.14/17.52)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.82|      15|      18|    1663|    1680|       3
---------------------------------------------------------------------------
 1663- 1680 (18.50/22.94)	NKIAGFDsIFkkEGLQVS
 1683- 1697 (30.32/20.83)	QKISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.16|      16|      17|    1230|    1245|       4
---------------------------------------------------------------------------
 1230- 1245 (28.77/15.47)	LGDAE.LKGSGFTVTGG
 1249- 1265 (26.39/13.55)	LPEEEgGGGSGGRRQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.27|      16|      17|    1792|    1807|       5
---------------------------------------------------------------------------
 1792- 1807 (31.23/20.73)	RSQPAAKT..ED..YGMGPG
 1808- 1827 (24.04/13.72)	RSGPYGVTvpPDllHHPNPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.29|      20|      24|    1956|    1977|       6
---------------------------------------------------------------------------
 1958- 1977 (38.76/27.56)	GPAGTMVPPSYSSQ..PYQSTH
 1979- 2000 (32.54/14.56)	STNPTLVDPTRHLQqrPSGYVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      24|    1561|    1574|       7
---------------------------------------------------------------------------
 1561- 1574 (24.50/14.04)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/10.39)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.70|      22|      24|     471|     494|       8
---------------------------------------------------------------------------
  466-  493 (30.25/27.49)	HsferSDFSNSLDSLCNriFGLGPSKDG
  494-  518 (34.45/23.59)	H.eisSDDDAVVSLLCE..WAVSCKRSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.35|      20|      22|    2014|    2034|       9
---------------------------------------------------------------------------
 2014- 2034 (30.40/20.19)	QFQRQgLQQTQQQQQTAALVR
 2035- 2054 (35.95/19.37)	QLQQQ.LSNTQPQPSTNIFGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      17|      22|     334|     353|      10
---------------------------------------------------------------------------
  337-  353 (32.74/25.21)	PTSSTPSTPFSDLLM.CP
  357-  374 (26.91/ 9.49)	PLVFGLSCILQTILLcCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      11|      22|    1075|    1085|      11
---------------------------------------------------------------------------
 1075- 1085 (21.19/11.05)	AILCAELTGYC
 1098- 1108 (22.77/12.43)	ALCCSSNNGTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.27|      66|     202|     912|     988|      12
---------------------------------------------------------------------------
  912-  988 (98.43/104.21)	SDLvgSYTTSLClCIVAVLRHYHaCLILnQDQMAqvfeglCGVVKHGMN....RSDGSSAER..C.ILAYLYDL..YTSCSHLKNK
 1120- 1194 (97.84/68.71)	SDL..SFHDSLA.TFVAILIARQ.CLLL.EDLIR......CAAIPSLLNaacsEQDSEPGARltCrILLHLFKTpqLNPCQSDGNK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.82|      21|     565|    1339|    1360|      13
---------------------------------------------------------------------------
 1339- 1360 (37.01/23.93)	PQRQRIKRILQNlDQWTMRQSS
 1906- 1926 (38.80/21.19)	PQGQRLRQQLQQ.SQGMLGQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.97|      21|     123|    1732|    1755|      14
---------------------------------------------------------------------------
 1732- 1755 (33.87/32.50)	PRPRAYylEPLPLPPEdEEPPAPT
 1853- 1873 (42.11/26.43)	PRVDPY..RPVRLPMQ.KLPTRPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.31|      24|      24|     694|     717|      15
---------------------------------------------------------------------------
  694-  717 (42.89/22.62)	EGKGSPSPEKP.DVEKEVK.PPPKEK
  719-  744 (33.43/15.92)	EGTLGVLYDQPrHVQYATHfPIPQEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1027|    1039|      16
---------------------------------------------------------------------------
 1027- 1039 (25.11/16.88)	ENPAA.HTFTYTGL
 1045- 1058 (21.03/12.76)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     245.97|      75|     338|     189|     266|      18
---------------------------------------------------------------------------
  189-  266 (129.84/111.71)	IITKYLwEQLQKMAEYYRPGPA......GSGGCGSTIGP.LPHDVEVAIRQWDytEKLAMFMFQDGMLDRHEFLTWVLECFEKIR
  524-  605 (116.13/86.10)	VVAKLL.EKRQAEIEAERCGESeaadekGSIASGSLSAPsAPIFQDVLLQFLD..TQAPMLTDPRSESERVEFFNLVLLFCELIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      22|      23|    1611|    1632|      19
---------------------------------------------------------------------------
 1611- 1632 (34.88/23.78)	RAYMNLAKKLQKELGERQSDSL
 1636- 1657 (37.82/26.56)	RQLLPLPKQTRDVITCEPQGSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18922 with Med12 domain of Kingdom Metazoa
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