<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18914

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAVRWCKRSLRPPSWCIPRSSTTYTLLFLRLFLLKANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPGKMLLSLFDKVAASIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVSMLECNGVISTHCNLSLPDSSDSPASASQVAGNTGMCHHTWLIFVLLSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSVHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELKFPISSCLAIPVPSIPVHLSSGQPELPWLASPSRDGPFIKANSIALINF
Length1196
PositionTail
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.134
Instability index54.45
Isoelectric point8.94
Molecular weight131902.79
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18914
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     212.67|      42|      43|     918|     959|       1
---------------------------------------------------------------------------
  850-  900 (50.47/16.40)	SYHSTVnqSPSMMHT........QSPGNlHAASSPSGALRAP..SPASfvptppPSSHgiS
  918-  959 (84.09/31.66)	SPYTMV..SPSGRAG........NWPGS.PQVSGPSPAARMPGMSPAN......PSLH..S
  967- 1003 (40.20/11.74)	SP..........RAGtssqtmptNMPPP.RKLPQRSWAASIPTILT...........H..S
 1004- 1035 (37.91/10.71)	ALNILL..LPSPTPG........LVPGL.AGSYLCSPLERFLG..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      18|      43|      86|     108|       2
---------------------------------------------------------------------------
   86-  108 (14.82/30.00)	LFVRLLaLVKwANnaGKVeKCAV
  132-  149 (33.25/21.47)	LFLRLF.LLK.AN..GRV.KFRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     231.54|      72|     278|     300|     458|       3
---------------------------------------------------------------------------
  217-  300 (118.54/39.70)	NCLHSFClslqleVLHSQ..TLMLIRERWGDLVQVERYHAGKCLSLSVWNQQV...LGRKTGTASV.HKVTIKidendvSKPLQI..FHDPP
  336-  415 (113.00/100.48)	ECLHIFV......DLHSGmfQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLkfwLGQQRCKQSIkHLPTIS......SETLQLsnYSTHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.54|      36|     121|     575|     695|       4
---------------------------------------------------------------------------
  575-  617 (58.95/149.48)	LLSEPVggrkvveMFLNDWNSIARL...YECVLEFARSLPDIPAHL
 1128- 1166 (61.59/10.27)	LLGAPT.......HILRDCVHIMKLelkFPISSCLAIPVPSIPVHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.90|      34|      62|     472|     507|       5
---------------------------------------------------------------------------
  472-  507 (58.54/43.10)	GMCHHTWLIFVLLSNleIPHQGVQVEGDGFSHAIRL
  537-  570 (60.36/38.41)	GRNNRTWVAELVFAN..CPLNGTSTREQGPSRHVYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.25|      26|     802|      10|      38|       6
---------------------------------------------------------------------------
   10-   38 (45.49/23.97)	QLVPPGGGAPAPPPPGaavAAAAAAAASP
  822-  847 (53.76/23.15)	QLQPPPQQQPFPKQPG...TSGAYPLTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.49|      34|      42|     721|     756|       8
---------------------------------------------------------------------------
  721-  756 (55.84/50.72)	NTAYQCF..SILPQS...STHIRlAFRNMYcIDIY..CRSRGV
  761-  801 (44.65/29.72)	DGAYSLFdnSKLVEGfypAPGLK.TFLNMF.VDSNqdARRRSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.07|      22|     110|     307|     333|       9
---------------------------------------------------------------------------
  307-  333 (34.98/30.72)	LS...LFDKVaasieTALPA.LVVPILEPCG
  419-  444 (32.09/17.59)	LSknkLFIKL.....TRLPQyYIVSMLECNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.36|      12|      36|    1073|    1084|      12
---------------------------------------------------------------------------
 1073- 1084 (20.95/12.19)	RVALSPKTNQTL
 1111- 1122 (22.41/13.63)	RVAGPPFKANTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18914 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
793
993










Molecular Recognition Features






MoRF SequenceStartStop




NANANA