<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18913

Description Mediator complex subunit 14
SequenceMAPVQLENHQLVPPGGGAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAVRWCKRSLRPPSWCIPRSSTTYTLLFLRLFLLKANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPGKMLLSLFDKVAASIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVSMQRSDLESGIIGSYGKCVFNFVENCKLFSKLSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSVHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELKFPISSCLAIPVPSIPVHLSSGQPELPWLASPSRDGPFIKANSIALINF
Length1181
PositionTail
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.07
Grand average of hydropathy-0.149
Instability index53.47
Isoelectric point9.08
Molecular weight130558.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18913
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     212.67|      42|      42|     903|     944|       1
---------------------------------------------------------------------------
  835-  885 (50.47/17.09)	SYHSTVnqSPSMMHT........QSPGNlHAASSPSGALRAP..SPASfvptppPSSHgiS
  903-  944 (84.09/33.04)	SPYTMV..SPSGRAG........NWPGS.PQVSGPSPAARMPGMSPAN......PSLH..S
  952-  988 (40.20/12.22)	SP..........RAGtssqtmptNMPPP.RKLPQRSWAASIPTILT...........H..S
  989- 1020 (37.91/11.14)	ALNILL..LPSPTPG........LVPGL.AGSYLCSPLERFLG..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      18|      43|      86|     108|       2
---------------------------------------------------------------------------
   86-  108 (14.82/31.76)	LFVRLLaLVKwANnaGKVeKCAV
  132-  149 (33.25/22.73)	LFLRLF.LLK.AN..GRV.KFRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.57|      14|      42|     418|     431|       3
---------------------------------------------------------------------------
  418-  431 (24.18/15.05)	NLSKN.KLFIKLTRL
  458-  472 (20.40/11.64)	NFVENcKLFSKLSNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.12|      20|      43|     290|     310|       4
---------------------------------------------------------------------------
  290-  309 (37.83/23.22)	SKPLQIFHD..PPLPGKMLLSL
  335-  356 (33.29/14.59)	SECLHIFVDlhSGMFQLMLYGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.79|      93|     121|     596|     716|       5
---------------------------------------------------------------------------
  600-  716 (135.52/131.18)	AHLNI.FSE...VRVYnyrklilCygTTKG......SSISIQWNS.VHQKFHislgtvgPNSGCSNCHNTILHQLQEMFNKT.......PNVV..QLLQVLFDTQAPLNAINKLPTVPmlGltqrTNTAYQCFSilP
  720-  832 (138.27/75.35)	THIRLaFRNmycIDIY.......C..RSRGvvairdGAYSLFDNSkLVEGFY.......PAPGLKTFLNMFVDSNQDARRRSvneddnpPSPIggDMMDSLISQLQPPPQQQPFPKQP..G....TSGAYPLTS..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.48|      30|      32|     197|     226|       6
---------------------------------------------------------------------------
  169-  196 (37.82/21.98)	..............RLLKLEILVEDKETGDGRALVHSMQISF
  197-  226 (53.88/34.27)	IH............QLVQSRLFADEKPLQDMYNCLHSFCLSL
  231-  260 (22.78/10.46)	LHsqtlmlirerwgDLVQVERYHAGK............CLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.19|      20|     122|     263|     282|       7
---------------------------------------------------------------------------
  263-  282 (36.64/26.09)	WNQQV...LGRKTGTASV.HKVTI
  378-  401 (29.55/19.50)	WIQQLkfwLGQQRCKQSIkHLPTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.36|      12|      38|    1058|    1069|       8
---------------------------------------------------------------------------
 1058- 1069 (20.95/12.12)	RVALSPKTNQTL
 1096- 1107 (22.41/13.55)	RVAGPPFKANTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18913 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
778
978










Molecular Recognition Features






MoRF SequenceStartStop




NANANA