<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18907

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVNEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAIEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTEYVFFLIYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGLCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKPLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFSKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLYPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2143
PositionMiddle
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.08
Grand average of hydropathy-0.370
Instability index53.84
Isoelectric point5.31
Molecular weight235694.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18907
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     942.52|     303|     402|    1212|    1538|       1
---------------------------------------------------------------------------
  933- 1043 (59.90/12.86)	..............................................................................................................................................................................................................................................................................................DGSNMDQeygPAYTPQTHT.SFGMPPSSappSNSGAGILPSPSTPRFPTPRTPR..TprtprgAGGPA.....SAqgSVKYENSDLYSPASTPSTCRPLNS.VEPATVPSIPEAHSLYVN
 1212- 1536 (473.66/233.93)	MDNMSGGKVDEALVKSSClypWS...KRNDVSM.QCSQDILRMLLSLQ..P...VLQDAIQKKRTVRPWGVQGpLTWQQFHKMagRGSYGTDESPEPLpiPTFLLGYDYDYLVLSPfALPYWERLMLEPY......GSQRDI..AYVVLCPENEALLNG.........................................AKSFfrDLTAIYESCrLGQHRPVSRLLTDGIMRVGSTASNKLSeklvaEWFSQAADGNNEAFSK.LKlyaQVCRYdLGPYLASLPlDSSLLSQ...PNLVAPTSQ.SLITPPQM...TNTGNANTPSATLASAASSTMTM..T......SGVAI.....ST..SVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSN
 1613- 1960 (408.96/165.30)	IDPFTYENTDESTNSSSV...WTlglLRCFLEMvQTLPPHIKSTVSVQiiPcqyLLQPVKHEDREIYPQHLKS.LAFSAFTQC..RRPLPTSTNVKTL..TGFGPGLAMETALRSP.DRPECIRLYAPPFilapvkDKQTELgeTFGEAGQKYNVLFVGyclshdqrwilasctdlygelletciinidvpnrarrkkssARKF..GLQKLWEWC.LGLVQMSSLPWRVVIGRLGRIGHGELK.....DWSCLLSRRNLQSLSKrLK...DMCRM.CGISAADSP...SILS....ACLVAMEPQgSFVIMPDS...VSTGSVFGRSTTLNMQTSQLNTPqdT......SCTHIlvfptSA..SVQVASATYTTENLDLAFNPN.NDG..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.09|      25|      26|     853|     877|       2
---------------------------------------------------------------------------
  853-  877 (46.99/27.16)	VDEGLCSP.KPSEIKDFSYVYKPENC
  881-  906 (44.11/24.96)	VGCSMFAPlKPLPSQYLPPIKLPEEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     735.60|     237|     263|      21|     283|       3
---------------------------------------------------------------------------
   21-  283 (381.98/301.25)	CLadltGIKWKKYVWQGPT.SAPILFPVT..EE....DPilSSFSRCLK.ADVLGVWRRDQRPGRrelwifwWGEDP.NFADLIHHDLSEEED.GVWENGLSYECRT..LLFKAVhnllERCLMNRNFVRIGKwfvNEHLSCSFTFFLHG.DSNVCTSVEINQHQPVyLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLI....GEWKQFYPISCC.LKEMSEEKQEDM..DWEDDSLA..AVEVLVAGVRMIyPACfvlvPQS....DIPTPSP
  293-  555 (353.62/221.36)	CL....GVHQVPASTRDPAmSSVTLTPPTspEEvqtvDP..QSAQKWVKfSSVSDGFNSDSTSHH.......GGKIPrKLANHVVDRVWQECNmNRAQNKRKYSASSggLCEEAT....AAKVASWDFVEATQ...RTNCSCLRHKNLKSrNAGQGQAPSLGQQQQI.LPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVisapDSQVRFSNIRTNdVAKTPQMHGTEManSPQPPPLSphPCDVVDEGVTKT.PST....PQSqhfyQMPTPDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.99|      15|      26|    1565|    1581|       4
---------------------------------------------------------------------------
 1565- 1581 (19.21/18.38)	GI..SGESSSLpTQPhPDV
 1592- 1608 (24.78/11.64)	GIptDGDSHAI.TYP.PAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.22|      29|      30|    1069|    1097|       5
---------------------------------------------------------------------------
 1069- 1097 (54.94/38.15)	MNIK.GADVGVYIPDPTQEAQYRCTCGFSA
 1099- 1128 (46.27/30.75)	MNRKfGNSSGLFLEDELDIIGRNTDCGKEA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.47|      19|      31|     626|     646|       6
---------------------------------------------------------------------------
  626-  646 (30.31/23.44)	KDDPVGPFGqeSVTSVTEYVF
  660-  678 (33.16/19.33)	QEPKIDPYA..FVEGDEEFLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.37|      50|     444|     684|     738|       8
---------------------------------------------------------------------------
  684-  736 (76.70/52.06)	RQNSERE...AGKKhKVEDGTSSVTvlSHEEDAMSLFSP.SIKQDAPRPASHARPPS
  755-  808 (79.67/39.48)	LFNSDEDeltPGSK.KSANGSDDKA..SCKESKTGNLDPlSCISTADLHKMYPTPPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18907 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
2) CLRHKNLKSRNAGQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
3) GSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHE
4) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
5) VAPTSQSLITPPQMTNTGNANTPSATLASAA
925
414
1990
1500
1449
1008
574
2022
1598
1479










Molecular Recognition Features






MoRF SequenceStartStop




NANANA