<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18895

Description Cyclin dependent kinase 19
SequenceMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQVPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSNVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
Length442
PositionKinase
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.08
Grand average of hydropathy-0.654
Instability index57.41
Isoelectric point8.79
Molecular weight49894.91
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18895
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.52|      37|      41|     259|     295|       1
---------------------------------------------------------------------------
  259-  295 (67.83/31.68)	DPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPK
  303-  339 (69.69/32.74)	DPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQVPPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.77|      33|      37|     364|     400|       2
---------------------------------------------------------------------------
  350-  372 (14.72/ 8.01)	..........G.GAGAGVGG......TGAglqhsqDSGLN
  373-  406 (57.56/28.58)	QVPPNKKPRLG.PSGANSGGPVMPSDYQH.....sSSRLN
  412-  440 (36.49/14.65)	QGSSQSQSTLGySSSSQQSSQYHPSHQAH...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.22|      36|      40|     127|     166|       3
---------------------------------------------------------------------------
   91-  117 (31.61/18.37)	.........DLKPANILVMGEGPE.....RGRVKIADMgFA
  120-  159 (59.27/50.55)	FNSPLKPLADLDPVVVTFWYRAPELllgaRHYTKAIDI.WA
  160-  181 (28.35/14.46)	IGCIFAELLTSEPI...FHCRQEDI................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18895 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQVPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSGLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSNVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
293
442










Molecular Recognition Features






MoRF SequenceStartStop




1) NKKPRLG
2) QYHPSHQAHRY
377
432
383
442