<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18884
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | TSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNSSVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGSKNPELGSG |
Length | 485 |
Position | Middle |
Organism | Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini>
Cercopithecidae> Colobinae> Rhinopithecus.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.136 |
Instability index | 51.96 |
Isoelectric point | 6.68 |
Molecular weight | 53450.97 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP18884
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 122.74| 37| 48| 75| 122| 1
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75- 112 (60.44/51.28) NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
125- 163 (62.30/29.73) NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 189.97| 47| 51| 260| 310| 2
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213- 257 (55.58/29.06) .....WTPSFSSIT....SANSVDLPACFFL.KF...PQPIPVSR..A...FVQKlqsctGIP
260- 310 (73.27/53.85) ETQPTYAPLYELITqFelSKDPDPIPLNHNM.RF...YAALPGQQhCY...FLNK.....DAP
313- 364 (61.12/32.61) DGRSLQGTLVSKIT.F...QHPGRVPLILNLiRHqvaYNTLIGS..CVkrtILKE.....DSP
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