<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18882

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVLLMLSICFYVSFNVNLPYSIITFFVTSFFHPLIVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNSSVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1547
PositionMiddle
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.05
Grand average of hydropathy-0.630
Instability index53.49
Isoelectric point8.77
Molecular weight164590.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18882
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     426.14|      50|      50|    1048|    1097|       1
---------------------------------------------------------------------------
  948-  998 (53.32/12.36)	LAG........PGLDSKPGKR....SRTPSNDG.......KSKDKP..PKRK.K.......................A...DTEGK.SP.SHSSSnrpfTP
  999- 1047 (43.48/ 8.56)	PTS........TG.....GSK.SPGSSGRSQTP.......PGVATPpiPKIT.I.......................Q...IPKGTvMV.GKPSS...hSQ
 1048- 1097 (87.84/25.69)	YTS........SGSVSSSGSK.SHHSHSSSSSS.......SSASTS..GKMK.S.......................S...KSEGS.SS.SKLSS....SM
 1098- 1148 (54.15/12.68)	YSS........QGSSGSSQSKnSSQSGGKPGSSpitkhglSSGSSS..TKM..............................KPQG......KPSS....LM
 1151- 1191 (50.75/11.37)	SLS........KPNISPS......HSRPPGGSD.......KLAS.....PMK.P.......................V.....PGTpPS.SKAKS....PI
 1233- 1280 (56.90/13.75)	TAS........SSSFSSSGSS.MSSSQNQHGSS.......KGKSPS..RNKK.P.......................S...LT..A.VI.DKLKH....GV
 1281- 1342 (42.77/ 8.29)	VTSgpggedplDGQMGVSTNS.SSHPMSSKHNM.......SGGEFQ..GKRE.K.......................SdkdKSKVS.TSgSSVDS....SK
 1442- 1512 (36.94/ 6.04)	YQN........SPS.SDDGIR.PLPEYSTEKHK.......KHKKEK..KKVKdKdrdrdrdkdrdkkkshsikpeswS...KSPIS.SD.QSL......SM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     244.76|      50|      50|     289|     338|       2
---------------------------------------------------------------------------
  251-  287 (49.71/20.90)	....PSF.SSITSANSVDLPACFFL.KFPQPIPVSRA.................F...VQKL...Q..
  289-  338 (94.87/46.21)	CTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNM...............RF...YAALPGQQHC
  349-  389 (43.58/17.46)	.......DGRSLQGTLVSKIT.F...QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  399-  454 (56.61/24.77)	SPGLLQFEV....CPLSE..SRFSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.48|      17|      20|     506|     523|       3
---------------------------------------------------------------------------
  506-  522 (35.50/14.17)	PPASSPGYGMTTGNNPM
  528-  543 (26.04/ 7.58)	PTNTFPGGPITTLFN.M
  594-  609 (27.94/ 8.46)	PPPVSSMAG.NTKNHPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     232.76|      42|     117|     548|     589|       4
---------------------------------------------------------------------------
  548-  583 (53.82/22.27)	...................................KDRH......ESVGHGED..F.SK.......V.SQ.....NP.ILTSLLQITGNGGSTI
  584-  643 (39.17/14.01)	GSSPTP....phhtpppvssmagntknhpmlmnllKD.........N..PAQD..F.ST.......L.YG.....SS.PLER..QNSSSGSPRM
  648-  701 (38.50/13.64)	GSNKT...................kkkkssrlppeKPKH......QT...EDD..F.QRelfsmdvD.SQ.....NP.IFD..VNMTADTLDTP
  702-  768 (29.56/ 8.60)	HITPAPsqcstppttypqpvphpqpsiqrmvrlssSD.........SI..GPD..V.TD.......IlSD.....IA.EEASKLPSTSDDGPAI
  769-  815 (26.04/ 6.61)	G......................................tplrdsSSSGHSQStlFdSD.......V.FQtnnneNP.YTDPADLIADAAGSPS
  816-  848 (45.66/17.67)	SDSPT.................................N......HFFHDGVD..F...................NPdLLNSQSQ.SGFGEEYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.51|      37|      45|    1347|    1385|       5
---------------------------------------------------------------------------
 1347- 1385 (54.97/30.22)	SKNVGSTGVAKiIISKHDGGSPSiKAKVTLQKPGESSGE
 1394- 1430 (68.53/31.06)	SKNYGSPLISG.STPKHERGSPS.HSKSPAYTPQNLDSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.74|      37|      49|     111|     148|       6
---------------------------------------------------------------------------
  111-  148 (60.44/42.19)	NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  161-  199 (62.30/39.14)	NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.93|      13|      49|     872|     884|       9
---------------------------------------------------------------------------
  872-  884 (24.99/13.63)	GVPMLGGDNGESK
  907-  919 (20.94/10.01)	GPADLMEHHSGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      13|      35|     856|     868|      11
---------------------------------------------------------------------------
  856-  868 (23.80/14.69)	DNDDFK..GFASQAL
  892-  906 (17.34/ 8.55)	DTVDFSiiSVAGKAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18882 with Med1 domain of Kingdom Metazoa
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