<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18882

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMVLLMLSICFYVSFNVNLPYSIITFFVTSFFHPLIVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNSSVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1547
PositionMiddle
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.05
Grand average of hydropathy-0.630
Instability index53.49
Isoelectric point8.77
Molecular weight164590.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
chromatin binding	GO:0003682	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18882
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     426.14|      50|      50|    1048|    1097|       1
---------------------------------------------------------------------------
  948-  998 (53.32/12.36)	LAG........PGLDSKPGKR....SRTPSNDG.......KSKDKP..PKRK.K.......................A...DTEGK.SP.SHSSSnrpfTP
  999- 1047 (43.48/ 8.56)	PTS........TG.....GSK.SPGSSGRSQTP.......PGVATPpiPKIT.I.......................Q...IPKGTvMV.GKPSS...hSQ
 1048- 1097 (87.84/25.69)	YTS........SGSVSSSGSK.SHHSHSSSSSS.......SSASTS..GKMK.S.......................S...KSEGS.SS.SKLSS....SM
 1098- 1148 (54.15/12.68)	YSS........QGSSGSSQSKnSSQSGGKPGSSpitkhglSSGSSS..TKM..............................KPQG......KPSS....LM
 1151- 1191 (50.75/11.37)	SLS........KPNISPS......HSRPPGGSD.......KLAS.....PMK.P.......................V.....PGTpPS.SKAKS....PI
 1233- 1280 (56.90/13.75)	TAS........SSSFSSSGSS.MSSSQNQHGSS.......KGKSPS..RNKK.P.......................S...LT..A.VI.DKLKH....GV
 1281- 1342 (42.77/ 8.29)	VTSgpggedplDGQMGVSTNS.SSHPMSSKHNM.......SGGEFQ..GKRE.K.......................SdkdKSKVS.TSgSSVDS....SK
 1442- 1512 (36.94/ 6.04)	YQN........SPS.SDDGIR.PLPEYSTEKHK.......KHKKEK..KKVKdKdrdrdrdkdrdkkkshsikpeswS...KSPIS.SD.QSL......SM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     244.76|      50|      50|     289|     338|       2
---------------------------------------------------------------------------
  251-  287 (49.71/20.90)	....PSF.SSITSANSVDLPACFFL.KFPQPIPVSRA.................F...VQKL...Q..
  289-  338 (94.87/46.21)	CTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNM...............RF...YAALPGQQHC
  349-  389 (43.58/17.46)	.......DGRSLQGTLVSKIT.F...QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  399-  454 (56.61/24.77)	SPGLLQFEV....CPLSE..SRFSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.48|      17|      20|     506|     523|       3
---------------------------------------------------------------------------
  506-  522 (35.50/14.17)	PPASSPGYGMTTGNNPM
  528-  543 (26.04/ 7.58)	PTNTFPGGPITTLFN.M
  594-  609 (27.94/ 8.46)	PPPVSSMAG.NTKNHPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     232.76|      42|     117|     548|     589|       4
---------------------------------------------------------------------------
  548-  583 (53.82/22.27)	...................................KDRH......ESVGHGED..F.SK.......V.SQ.....NP.ILTSLLQITGNGGSTI
  584-  643 (39.17/14.01)	GSSPTP....phhtpppvssmagntknhpmlmnllKD.........N..PAQD..F.ST.......L.YG.....SS.PLER..QNSSSGSPRM
  648-  701 (38.50/13.64)	GSNKT...................kkkkssrlppeKPKH......QT...EDD..F.QRelfsmdvD.SQ.....NP.IFD..VNMTADTLDTP
  702-  768 (29.56/ 8.60)	HITPAPsqcstppttypqpvphpqpsiqrmvrlssSD.........SI..GPD..V.TD.......IlSD.....IA.EEASKLPSTSDDGPAI
  769-  815 (26.04/ 6.61)	G......................................tplrdsSSSGHSQStlFdSD.......V.FQtnnneNP.YTDPADLIADAAGSPS
  816-  848 (45.66/17.67)	SDSPT.................................N......HFFHDGVD..F...................NPdLLNSQSQ.SGFGEEYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.51|      37|      45|    1347|    1385|       5
---------------------------------------------------------------------------
 1347- 1385 (54.97/30.22)	SKNVGSTGVAKiIISKHDGGSPSiKAKVTLQKPGESSGE
 1394- 1430 (68.53/31.06)	SKNYGSPLISG.STPKHERGSPS.HSKSPAYTPQNLDSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.74|      37|      49|     111|     148|       6
---------------------------------------------------------------------------
  111-  148 (60.44/42.19)	NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  161-  199 (62.30/39.14)	NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.93|      13|      49|     872|     884|       9
---------------------------------------------------------------------------
  872-  884 (24.99/13.63)	GVPMLGGDNGESK
  907-  919 (20.94/10.01)	GPADLMEHHSGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      13|      35|     856|     868|      11
---------------------------------------------------------------------------
  856-  868 (23.80/14.69)	DNDDFK..GFASQAL
  892-  906 (17.34/ 8.55)	DTVDFSiiSVAGKAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18882 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
2) FNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFN
3) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQAD
902
541
503
834
1547
831
536
892










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFD
2) IKAKVTLQK
3) IRPLPEYSTEKHKKHKKEKKKVKDKDRD
4) ITIQIPK
5) KPSLTAVIDKLKHGV
6) RLSPDFMIGEEDDDLMDV
7) VAKIIISKH
843
1370
1452
1028
1266
1525
1355
849
1378
1479
1034
1280
1542
1363