<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18881

Description Mediator of RNA polymerase II transcription subunit 1
SequenceTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNSSVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1511
PositionMiddle
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.05
Grand average of hydropathy-0.685
Instability index54.29
Isoelectric point8.79
Molecular weight160391.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364059

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     462.25|      50|      50|    1012|    1061|       1
---------------------------------------------------------------------------
  912-  962 (53.32/13.33)	LAG........PGLDSKPGK.R....SRTPSNDG.......KSKDKP..PKRK.K.......................A...DTEGK.SP.SHSSSnrpfTP
  963- 1011 (43.48/ 9.25)	PTS........TG.....GS.K.SPGSSGRSQTP.......PGVATPpiPKIT.I.......................Q...IPKGTvMV.GKPSS...hSQ
 1012- 1061 (87.84/27.62)	YTS........SGSVSSSGS.K.SHHSHSSSSSS.......SSASTS..GKMK.S.......................S...KSEGS.SS.SKLSS....SM
 1062- 1112 (54.15/13.67)	YSS........QGSSGSSQS.KnSSQSGGKPGSSpitkhglSSGSSS..TKM..............................KPQG......KPSS....LM
 1115- 1155 (50.75/12.26)	SLS........KPNISPS.......HSRPPGGSD.......KLAS.....PMK.P.......................V.....PGTpPS.SKAKS....PI
 1156- 1190 (36.11/ 6.19)	................SSGSgG.SHMSGTSSS..............S..G.MK.S.......................S...SGLGS.SG.S.LSQ...kTP
 1197- 1244 (56.90/14.81)	TAS........SSSFSSSGS.S.MSSSQNQHGSS.......KGKSPS..RNKK.P.......................S...LT..A.VI.DKLKH....GV
 1245- 1306 (42.77/ 8.95)	VTSgpggedplDGQMGVSTN.S.SSHPMSSKHNM.......SGGEFQ..GKRE.K.......................SdkdKSKVS.TSgSSVDS....SK
 1406- 1476 (36.94/ 6.54)	YQN........SPS.SDDGI.R.PLPEYSTEKHK.......KHKKEK..KKVKdKdrdrdrdkdrdkkkshsikpeswS...KSPIS.SD.QSL......SM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     244.76|      50|      50|     253|     302|       2
---------------------------------------------------------------------------
  215-  251 (49.71/25.28)	....PSF.SSITSANSVDLPACFFL.KFPQPIPVSRA.................F...VQKL...Q..
  253-  302 (94.87/55.64)	CTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNM...............RF...YAALPGQQHC
  313-  353 (43.58/21.16)	.......DGRSLQGTLVSKIT.F...QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  363-  418 (56.61/29.93)	SPGLLQFEV....CPLSE..SRFSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.48|      17|      20|     470|     487|       3
---------------------------------------------------------------------------
  470-  486 (35.50/11.80)	PPASSPGYGMTTGNNPM
  492-  507 (26.04/ 6.25)	PTNTFPGGPITTLFN.M
  558-  573 (27.94/ 6.99)	PPPVSSMAG.NTKNHPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.69|      39|      49|    1311|    1351|       4
---------------------------------------------------------------------------
 1311- 1351 (59.92/32.27)	SKNVGSTGVAKiIISKHDGGSPSiKAKVTLQKP....GES.SGEGL
 1358- 1401 (62.77/27.14)	SKNYGSPLISG.STPKHERGSPS.HSKSPAYTPqnldSESeSGSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     232.76|      42|     117|     512|     553|       5
---------------------------------------------------------------------------
  512-  547 (53.82/22.93)	...................................KDRH......ESVGHGED..F.SK.......V.SQ.....NP.ILTSLLQITGNGGSTI
  548-  607 (39.17/14.42)	GSSPTP....phhtpppvssmagntknhpmlmnllKD.........N..PAQD..F.ST.......L.YG.....SS.PLER..QNSSSGSPRM
  612-  665 (38.50/14.03)	GSNKT...................kkkkssrlppeKPKH......QT...EDD..F.QRelfsmdvD.SQ.....NP.IFD..VNMTADTLDTP
  666-  732 (29.56/ 8.82)	HITPAPsqcstppttypqpvphpqpsiqrmvrlssSD.........SI..GPD..V.TD.......IlSD.....IA.EEASKLPSTSDDGPAI
  733-  779 (26.04/ 6.78)	G......................................tplrdsSSSGHSQStlFdSD.......V.FQtnnneNP.YTDPADLIADAAGSPS
  780-  812 (45.66/18.19)	SDSPT.................................N......HFFHDGVD..F...................NPdLLNSQSQ.SGFGEEYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.74|      37|      49|      75|     112|       6
---------------------------------------------------------------------------
   75-  112 (60.44/47.80)	NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  125-  163 (62.30/44.34)	NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.93|      13|      51|     836|     848|       8
---------------------------------------------------------------------------
  836-  848 (24.99/11.13)	GVPMLGGDNGESK
  871-  883 (20.94/ 8.13)	GPADLMEHHSGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      13|      35|     820|     832|      10
---------------------------------------------------------------------------
  820-  832 (23.80/17.06)	DNDDFK..GFASQAL
  856-  870 (17.34/10.09)	DTVDFSiiSVAGKAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18881 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
2) FNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFN
3) KNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGP
4) LLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQAD
866
505
467
798
1511
795
500
856










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFD
2) IKAKVTLQ
3) IRPLPEYSTEKHKKHKKEKKKVKDKDRD
4) ITIQIPK
5) KPSLTAVIDKLKHGV
6) RLSPDFMIGEEDDDLMDV
7) VAKIIISKH
807
1334
1416
992
1230
1489
1319
813
1341
1443
998
1244
1506
1327