<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18881

Description Mediator of RNA polymerase II transcription subunit 1
SequenceTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNSSVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDGPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGESKFKANNQADTVDFSIISVAGKALGPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLAGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1511
PositionMiddle
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.05
Grand average of hydropathy-0.685
Instability index54.29
Isoelectric point8.79
Molecular weight160391.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     462.25|      50|      50|    1012|    1061|       1
---------------------------------------------------------------------------
  912-  962 (53.32/13.33)	LAG........PGLDSKPGK.R....SRTPSNDG.......KSKDKP..PKRK.K.......................A...DTEGK.SP.SHSSSnrpfTP
  963- 1011 (43.48/ 9.25)	PTS........TG.....GS.K.SPGSSGRSQTP.......PGVATPpiPKIT.I.......................Q...IPKGTvMV.GKPSS...hSQ
 1012- 1061 (87.84/27.62)	YTS........SGSVSSSGS.K.SHHSHSSSSSS.......SSASTS..GKMK.S.......................S...KSEGS.SS.SKLSS....SM
 1062- 1112 (54.15/13.67)	YSS........QGSSGSSQS.KnSSQSGGKPGSSpitkhglSSGSSS..TKM..............................KPQG......KPSS....LM
 1115- 1155 (50.75/12.26)	SLS........KPNISPS.......HSRPPGGSD.......KLAS.....PMK.P.......................V.....PGTpPS.SKAKS....PI
 1156- 1190 (36.11/ 6.19)	................SSGSgG.SHMSGTSSS..............S..G.MK.S.......................S...SGLGS.SG.S.LSQ...kTP
 1197- 1244 (56.90/14.81)	TAS........SSSFSSSGS.S.MSSSQNQHGSS.......KGKSPS..RNKK.P.......................S...LT..A.VI.DKLKH....GV
 1245- 1306 (42.77/ 8.95)	VTSgpggedplDGQMGVSTN.S.SSHPMSSKHNM.......SGGEFQ..GKRE.K.......................SdkdKSKVS.TSgSSVDS....SK
 1406- 1476 (36.94/ 6.54)	YQN........SPS.SDDGI.R.PLPEYSTEKHK.......KHKKEK..KKVKdKdrdrdrdkdrdkkkshsikpeswS...KSPIS.SD.QSL......SM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     244.76|      50|      50|     253|     302|       2
---------------------------------------------------------------------------
  215-  251 (49.71/25.28)	....PSF.SSITSANSVDLPACFFL.KFPQPIPVSRA.................F...VQKL...Q..
  253-  302 (94.87/55.64)	CTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNM...............RF...YAALPGQQHC
  313-  353 (43.58/21.16)	.......DGRSLQGTLVSKIT.F...QHPGRVPLILNL..............iRHqvaYNTLIGS..C
  363-  418 (56.61/29.93)	SPGLLQFEV....CPLSE..SRFSVSFQH...PVNDSLvcvvmdvqdsthvscKL...YKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.48|      17|      20|     470|     487|       3
---------------------------------------------------------------------------
  470-  486 (35.50/11.80)	PPASSPGYGMTTGNNPM
  492-  507 (26.04/ 6.25)	PTNTFPGGPITTLFN.M
  558-  573 (27.94/ 6.99)	PPPVSSMAG.NTKNHPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.69|      39|      49|    1311|    1351|       4
---------------------------------------------------------------------------
 1311- 1351 (59.92/32.27)	SKNVGSTGVAKiIISKHDGGSPSiKAKVTLQKP....GES.SGEGL
 1358- 1401 (62.77/27.14)	SKNYGSPLISG.STPKHERGSPS.HSKSPAYTPqnldSESeSGSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     232.76|      42|     117|     512|     553|       5
---------------------------------------------------------------------------
  512-  547 (53.82/22.93)	...................................KDRH......ESVGHGED..F.SK.......V.SQ.....NP.ILTSLLQITGNGGSTI
  548-  607 (39.17/14.42)	GSSPTP....phhtpppvssmagntknhpmlmnllKD.........N..PAQD..F.ST.......L.YG.....SS.PLER..QNSSSGSPRM
  612-  665 (38.50/14.03)	GSNKT...................kkkkssrlppeKPKH......QT...EDD..F.QRelfsmdvD.SQ.....NP.IFD..VNMTADTLDTP
  666-  732 (29.56/ 8.82)	HITPAPsqcstppttypqpvphpqpsiqrmvrlssSD.........SI..GPD..V.TD.......IlSD.....IA.EEASKLPSTSDDGPAI
  733-  779 (26.04/ 6.78)	G......................................tplrdsSSSGHSQStlFdSD.......V.FQtnnneNP.YTDPADLIADAAGSPS
  780-  812 (45.66/18.19)	SDSPT.................................N......HFFHDGVD..F...................NPdLLNSQSQ.SGFGEEYF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.74|      37|      49|      75|     112|       6
---------------------------------------------------------------------------
   75-  112 (60.44/47.80)	NFDEFSKHLKGLVNlYNLP..GDNKLKTKMYLALQSLEQD
  125-  163 (62.30/44.34)	NAGPLDKILHGSVG.YLTPrsGGHLMNLKYYVSPSDLLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.93|      13|      51|     836|     848|       8
---------------------------------------------------------------------------
  836-  848 (24.99/11.13)	GVPMLGGDNGESK
  871-  883 (20.94/ 8.13)	GPADLMEHHSGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.14|      13|      35|     820|     832|      10
---------------------------------------------------------------------------
  820-  832 (23.80/17.06)	DNDDFK..GFASQAL
  856-  870 (17.34/10.09)	DTVDFSiiSVAGKAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18881 with Med1 domain of Kingdom Metazoa
Unable to open file!