<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18872

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGIGGQQAPPGLGPILEDQARPSQNLLQLRPPQSQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGTNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length707
PositionUnknown
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.06
Grand average of hydropathy-0.234
Instability index58.27
Isoelectric point8.46
Molecular weight74116.10
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18872
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.51|      20|      20|     350|     369|       2
---------------------------------------------------------------------------
  350-  369 (38.83/10.06)	VAPGSGLAPT.......AQPGAPSM.AG
  640-  667 (30.68/ 6.13)	PPPQTGVPPPqaslhhlQPPGAPSWpAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.04|      26|     283|     322|     348|       5
---------------------------------------------------------------------------
  232-  258 (42.74/ 8.77)	GGSAPgPLQPKQP.VPLPPAAPSGATLS
  322-  348 (48.30/13.27)	QAPAP.PLPPGPPgAPKPPPASQPSLVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.82|      31|     111|      39|      69|       7
---------------------------------------------------------------------------
   39-   69 (58.34/32.65)	YLLPAIEYFNGGPPAETDFGGDYG..GTQYSLV
  151-  183 (50.47/27.25)	YLLPAVESTTYSGCTTENLVQQIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.43|      15|      66|     616|     630|       8
---------------------------------------------------------------------------
  374-  387 (26.50/ 6.93)	GGVSGP.SPAQLGA.P
  616-  630 (33.83/11.20)	GAPQGP.PGTNPGANP
  682-  695 (26.10/ 6.69)	GGPRGPvP..QPGLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     464|     487|      10
---------------------------------------------------------------------------
  464-  487 (34.11/31.35)	LFrnSRMVQF.HFTNKDLESLKGLY
  493-  515 (37.50/26.64)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      15|      23|     422|     436|      11
---------------------------------------------------------------------------
  422-  436 (28.29/15.17)	KLTRSL.PCQVYVNHG
  447-  462 (21.42/ 9.82)	KLIMQLiPQQLLTTLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18872 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGIGGQQAPPGLGPILEDQARPSQNLLQLRPPQSQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGTNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
232
544
390
707










Molecular Recognition Features






MoRF SequenceStartStop




NANANA