<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18863

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHNKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQSEYHASWRICHFPCKRQHILFLSVVQQQQQQLQQQQQQQQHLIKLHHQNQQQVPGLLFLLLASLLQCEPWPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVSTCGPQWSTCSPWLCQQYAPAEPLHFQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALPGPWLTCFSHLSAAPALPHPPVASCPALHQLNGLTHLCPAVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKTLHTAHGGSTGAWIPTPHRPRWPRPNSGSSLCQPLLTPVLGPAHSFAAMTAIHGPTHPAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length658
PositionTail
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.05
Grand average of hydropathy-0.532
Instability index74.48
Isoelectric point9.03
Molecular weight72126.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18863
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.92|      25|      26|     214|     238|       1
---------------------------------------------------------------------------
  214-  238 (53.80/16.61)	LLQCEPWP.PMQQ...PQ..PPP.TQALPQQL
  241-  266 (40.36/10.40)	MHHPQHHQ.PPPQ...PQ..QPPvAQNQPSQL
  328-  358 (31.77/ 6.43)	SLPMLSSPsPGQQvqtPQsmPPP.PQPSPQPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.84|      24|      26|     364|     387|       2
---------------------------------------------------------------------------
  104-  122 (28.36/ 6.15)	RGPGQSLGGMGSL........GAMGQ..P
  371-  398 (38.68/10.88)	ALPGPWLTCFSHLSAAP.alPHPPVAscP
  399-  421 (30.06/ 6.94)	AL..HQLNGLTHLCPA..vnPSSVMS..P
  488-  509 (28.74/ 6.33)	RWPRP..NSGSSLC.QPlltP..VLG..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.90|      28|     123|     163|     198|       4
---------------------------------------------------------------------------
  163-  198 (42.38/30.42)	PCKrqhilFLSVVQQQ....QQQLQQQQQQQQHLiklHHQ
  292-  323 (49.51/20.21)	PLK.....FVSTCGPQwstcSPWLCQQYAPAEPL...HFQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.63|      11|      26|     616|     626|       5
---------------------------------------------------------------------------
  616-  626 (23.59/12.21)	NPFLQSVHR.CM
  644-  655 (19.03/ 8.59)	NTWAQSVHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      15|      34|      87|     103|       9
---------------------------------------------------------------------------
   87-  103 (25.33/16.67)	SLTGGPAAGAAgiGMPP
  124-  138 (31.40/14.83)	SLSGQPPPGTS..GMAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18863 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPA
2) KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVS
3) PWPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
4) RRMINKIDKNEDRKKDLSKMKTLHTAHGGSTGAWIPTPHRPRWPRPNSGSSL
322
73
219
447
371
145
284
498










Molecular Recognition Features






MoRF SequenceStartStop




NANANA