<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18861

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHNKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQSEYHASWRICHFPCKRQHILFLSVVQQQQQQLQQQQQQQQHLIKLHHQNQQQVPGLLFLLLASLLQCEPWPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALPGPWLTCFSHLSAAPALPHPPVASCPALHRTLGPSDGLTHLCPAVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKTLHTAHGGSTGAWIPTPHRPRWPRPNSGSSLCQPLLTPVLGPAHSFAAMTAIHGPTHPAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length710
PositionTail
OrganismRhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Colobinae> Rhinopithecus.
Aromaticity0.04
Grand average of hydropathy-0.489
Instability index74.72
Isoelectric point9.40
Molecular weight77301.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP18861
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     200.11|      43|      47|     216|     258|       1
---------------------------------------------------------------------------
  216-  258 (96.62/23.27)	QCEP..WPPMQQPQP..PPTQALPQQLQQMHHPQHHQPPPQP.......QQPPV
  260-  307 (49.49/ 8.57)	QNQPsqLPPQSQTQPlvSQAQALPGQML......YTQPPLKFvrapmvvQQPPV
  365-  402 (53.99/ 9.98)	GRQP..MAQVSQSSL..PMLSS.PSPGQQVQTPQSMPPPPQP.......S....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.63|      11|      27|     668|     678|       3
---------------------------------------------------------------------------
  668-  678 (23.59/13.05)	NPFLQSVHR.CM
  696-  707 (19.03/ 9.23)	NTWAQSVHQaCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.79|      34|     173|     456|     490|       8
---------------------------------------------------------------------------
  456-  490 (57.07/34.71)	DGLTHL.C.......PAVNPSSVMSPAgSSQAEEQQYLDKLKQ
  623-  664 (54.73/28.91)	NGTVHLiCklddkdlPSVPPLELSVPA.DYPAQSPLWIDRQWQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.94|      22|     119|     184|     205|      11
---------------------------------------------------------------------------
  184-  205 (40.92/21.25)	QQQQQQQHLIKLHHQNQQQVPG
  308-  329 (38.02/19.15)	QPQVQQQTAVQTAQAAQMVAPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.73|      11|      20|      88|      98|      12
---------------------------------------------------------------------------
   88-   98 (20.20/ 9.52)	LTGGPAAGAAG
  110-  120 (20.53/ 9.81)	LGGMGSLGAMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18861 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVRPALP
2) KSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVS
3) PHPPVASCPALHRTLGPSDGLTHLCPAVNPSSVMSPAGSSQAEEQQYLDKLKQ
4) PWPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALP
5) RRMINKIDKNEDRKKDLSKMKTLHTAHGGSTGAWIPTPHRPRWPRPNSGSSL
298
73
438
219
499
421
145
490
283
550










Molecular Recognition Features






MoRF SequenceStartStop




NANANA