<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18849

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWWCIPVVPATGQEDHLISLFLFGCPFYWFFFFLFSIFFSVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPTISQPGFSAGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQPLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPSNPESSDKWWHSYRLPSSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKIWQDKQPHVQPVHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKIKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQVEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCKLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGSAGPLAPNSGSTAPPAGSAFNPSSNGSSTNPATSSSTSGSSVPPVSSSASAPSISQISTTSSSGFTGSVGGQNPSTGGSSADRTQGNLGCGGDTEPGQSSSQPSQDGQESITERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILITGNLHSSPNSSPVPSPGSPGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2147
PositionMiddle
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.08
Grand average of hydropathy-0.369
Instability index58.97
Isoelectric point5.63
Molecular weight235914.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     198.84|      28|      28|     971|     998|       1
---------------------------------------------------------------------------
  384-  402 (23.89/ 6.46)	.........PGFS.....AGTSSSS..SLPPPASS
  954-  981 (42.52/18.08)	QMNTPVTLNSAAP.....ASNSGAG..VLPSPATP
  982- 1009 (41.86/17.67)	RFSVPTPRTPRTP.....RTPRGGG..TASGQGSV
 1501- 1522 (29.02/ 9.66)	NPSSNGSSNPATS.....SSTSGSS..V.......
 1524- 1552 (24.75/ 7.00)	....PVSSSASAPsisqiSTTSSSG..FTGSVGGQ
 1553- 1581 (36.79/14.51)	NPSTGGSSADRT......QGNLGCGgdTEPGQSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.81|      25|      27|    1796|    1822|       2
---------------------------------------------------------------------------
 1796- 1822 (40.53/26.96)	I...ALPNRSRRSKVSarKIGLQKLWEWCI
 1825- 1852 (40.29/21.15)	VqmtSLPWRVVIGRLG..RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.73|      13|      20|     876|     894|       3
---------------------------------------------------------------------------
  876-  894 (18.60/19.77)	PsfqpfvGSSMFAPLKMLP
  904-  916 (27.13/12.24)	P......DACLFRPSWAIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.78|      20|      20|    1625|    1644|       4
---------------------------------------------------------------------------
 1625- 1644 (37.03/26.84)	YTAEEDSTS...GNFWLLSLMRC
 1645- 1667 (31.75/21.68)	YTEMLDNLPehmRNSFILQIVPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.44|      11|      27|    1461|    1471|       5
---------------------------------------------------------------------------
 1461- 1471 (23.11/11.69)	LIPPKYQT.PPA
 1485- 1496 (17.33/ 6.46)	LAPNSGSTaPPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.19|      25|      27|    1054|    1078|       6
---------------------------------------------------------------------------
 1054- 1078 (49.69/29.14)	DSVMNIFKDRNFDSC.CICACN..MNIK
 1081- 1108 (39.50/21.68)	DVGLYIPDSSNEDQYrCTCGFSaiMNRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     428.01|     111|     112|     417|     528|       7
---------------------------------------------------------------------------
  417-  523 (186.28/90.81)	................QKRPLI..PFHHRPS.VAEELCMEQDTPGQKLGLAGIDSSLEV.SSSRKY........................D.KQMAVPSRNTSKQM....NL.............NPMDSPHS........................................PISPLPPTLSPQPRGQETESLDPPSVPVNPAL.....YGNG
  525-  658 (124.54/58.85)	ELQP..................lsTLDDRTVlVGQRLPLMAEVSETAL.YCGIRPS.NP.ESSDKWwhsyrlpssddaefrppelqgercD.AKMEVNSESTALQR....LLaqpnkrfkiwqdkQPHVQPVH........................................FLDPLP..LSQQP.G...DSLGEVN...DPYT.....FEDG
  659-  823 (117.19/51.97)	DIKYiftankkckqgtEKDSLK..KIKSEDG.FGTK...DVTTPGHSTPVPDGKNAMSIfSSATKT........................DvRQDNAAGRAGSSSLtqvtDL.............AP..SLHDldnifdnsdddelgavspalrsskmptvgtedrplgkdgrAAVPYPPTVADLQRMFPT....PPSLEQHPAFspvmnYKDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.76|      74|    1266|      93|     172|       8
---------------------------------------------------------------------------
   93-  172 (115.18/91.71)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAP..FQVLVSPYgLNGTLTGQAykmSDPATR.KL
 1362- 1438 (124.58/77.43)	PENEA.LLEGAKTFF.RDLSAVYEMCKLGQHKPICKVLRDGIMRVGKTVAQklTDELVSEW.FNQPWSGEE...NDNHSRlKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.16|      17|      22|    1968|    1987|       9
---------------------------------------------------------------------------
 1968- 1987 (29.05/20.66)	PFPDDMDNDIGIlitGN..LHS
 1993- 2011 (29.11/13.33)	PVPSPGSPGIGV...GShfQHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.37|      11|      20|    1313|    1323|      10
---------------------------------------------------------------------------
 1313- 1323 (21.66/11.86)	SPEPLPI.PTLL
 1334- 1345 (16.71/ 6.87)	SPFSLPFwERLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      20|      24|    1909|    1928|      12
---------------------------------------------------------------------------
 1909- 1928 (32.55/20.14)	VFGRSTALNMQSSQLNTPQD
 1934- 1953 (31.53/19.22)	ILVFPTSSTIQVAPANYPNE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18849 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAVGPSRPPTISQPGFSAGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKLGLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQ
2) ECILNRTQSKRSQMSTPTLEEEPANNPATWDFV
3) ITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGMQSATSHLGSQDGGMITMHSPKRSGKIPPKLH
4) NLHSSPNSSPVPSPGSPGIGVGSHFQHSRSQGERLLSREAP
5) PPKYQTPPAAAQGQATPGSAGPLAPNSGSTAPPAGSAFNPSSNGSSTNPATSSSTSGSSVPPVSSSASAPSISQISTTSSSGFTGSVGGQNPSTGGSSADRTQGNLGCGGDTEPGQSSSQPSQDGQESITERERIGIPTEPDSA
6) PSLHDLDNIFDNSDDDELGAVSPALRSSKMPTVGTEDRPLGKDGRAAVP
7) TEKDSLKKIKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTD
8) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
371
320
242
1984
1463
742
674
941
527
352
310
2024
1606
790
739
1038










Molecular Recognition Features






MoRF SequenceStartStop




NANANA