<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18832

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGATGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQALQPQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQPQQQLKFVRAPMVVQQPQVQPQVQQPQTAVQTAQTTQMAAPGVQMITEALTQGGMHIRARFPPTTAVSAVLSSSIPVGGQPTAQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYEANPFLKSVHRRMTARLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length786
PositionTail
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.03
Grand average of hydropathy-0.714
Instability index86.09
Isoelectric point9.55
Molecular weight86460.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18832
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     220.24|      37|      37|     150|     186|       1
---------------------------------------------------------------------------
  261-  295 (61.68/ 9.88)	QPQPP..MQQPPMQQPQP...PPSQalpQQLQQMH...HPQ....HH
  296-  339 (54.03/ 7.67)	QPPPQPQQPPVAQNQPSQlppQSQT...QPLVSQAQALPGQmlyaQP
  340-  373 (50.55/ 6.66)	QQQ..LKFVRAPM.VVQQ...PQVQ...PQVQQPQTAVQTA....QT
  418-  452 (53.99/ 7.65)	QPTAQVGQSSLPM..LSS...PSPG...QQVQTPQSMPPPP....QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.82|      19|      20|     152|     170|       2
---------------------------------------------------------------------------
  150-  168 (38.87/10.58)	QTQLQ.LQQVALQQQQQQQQ
  169-  185 (32.14/ 7.44)	QQQFQ.QQQAALQQQQQQ..
  200-  218 (37.54/ 9.96)	QAVVQ.QQQQQLQQQQQQQQ
  235-  254 (35.26/ 8.90)	QQQLQrMAQLQLQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.54|      17|      19|      86|     102|       3
---------------------------------------------------------------------------
   86-  102 (33.56/14.04)	QSLTGGPATGATGIGMP
  108-  124 (33.98/14.31)	QSLGGMGGLGAMGQPMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.37|      27|      28|     453|     479|       4
---------------------------------------------------------------------------
  453-  479 (54.97/26.39)	SPQPGQ.P..GSQP.NSNV.SSGP..AP.SPSSFL
  483-  517 (28.40/ 8.86)	SPQPSQsPvtARTPqNFSVpSPGPlnTPvNPSSVM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      29|      38|     531|     561|       6
---------------------------------------------------------------------------
  531-  561 (40.72/31.70)	LDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
  568-  597 (46.90/27.46)	LDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18832 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPATGATGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) KFVRAPMVVQQPQVQPQVQQPQTAVQTAQTTQMAAPGVQMITEALTQGGMHIRARFPPTTAVSAVLSSSIPVGGQPTAQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQPQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQPQQ
70
344
253
148
536
341










Molecular Recognition Features






MoRF SequenceStartStop




1) HIRAR
394
398