<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18831

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPATGATGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQALQPQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQPQQQLKFVRAPMVVQQPQVQPQVQQPQTAVQTAQTTQMAAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYEANPFLKSVHRRMTARLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length746
PositionTail
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.03
Grand average of hydropathy-0.763
Instability index86.93
Isoelectric point9.50
Molecular weight82398.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18831
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     202.77|      37|      37|     150|     186|       1
---------------------------------------------------------------------------
  261-  294 (52.09/ 7.33)	.QP.........QPP..MQQPPMQQPQP...PPSQalpQQLQQMH...HPQ....H
  295-  338 (48.57/ 6.27)	HQP.........PPQPQQPPVAQNQPSQlppQSQT...QPLVSQAQALPGQmlyaQ
  339-  372 (54.15/ 7.95)	PQQ.........Q..LKFVRAPM.VVQQ...PQVQ...PQVQQPQTAVQTA....Q
  373-  418 (47.96/ 6.09)	TTQmaapgvqvgQSSLPMLSSPSPGQQV...QTPQ...SMPPPPQPSPQPG....Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.68|      19|      20|     152|     170|       2
---------------------------------------------------------------------------
  166-  184 (41.63/12.66)	QQQQQQFQ.QQQAALQQQQQ
  198-  215 (29.01/ 6.31)	.QFQAVVQ.QQQQQLQQQQQ
  232-  251 (35.03/ 9.34)	QQQQQQLQrMAQLQLQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      17|      28|     431|     458|       3
---------------------------------------------------------------------------
  431-  450 (31.38/12.15)	PAPSPssfLPSP.SPQPSQSP
  462-  479 (29.28/ 6.82)	PSPGP...LNTPvNPSSVMSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.27|      21|      39|      80|     101|       4
---------------------------------------------------------------------------
   81-  101 (39.75/21.71)	PMNALQSLTGGPATGATGIGM
  103-  123 (41.52/18.37)	PRGPGQSLGGMGGLGAMGQPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      27|     521|     547|       5
---------------------------------------------------------------------------
  512-  539 (35.23/19.74)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  544-  568 (39.17/14.79)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18831 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPATGATGIGMPPRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) QQQQQQALQPQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQPQQQLKFVRAPMVVQQPQVQPQVQQPQTAVQTAQTTQMAAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
70
253
148
496










Molecular Recognition Features






MoRF SequenceStartStop




NANANA