<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18830

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQALQPQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQPQQQLKFVRAPMVVQQPQVQPQVQQPQTAVQTAQTTQMAAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYEANPFLKSVHRRMTARLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length675
PositionTail
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.04
Grand average of hydropathy-0.827
Instability index90.34
Isoelectric point9.50
Molecular weight75735.04
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18830
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.51|      35|      37|     178|     212|       1
---------------------------------------------------------------------------
  178-  212 (79.73/17.40)	QQQQQQQQQQALQPQPPMQQPPMQQPQP...PP.SQALP
  213-  251 (55.78/ 9.75)	QQLQQMHHPQHHQPPPQPQQPPVAQNQPsqlPPqSQTQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.27|      19|      19|      98|     116|       3
---------------------------------------------------------------------------
   98-  116 (38.13/ 9.87)	QQQFQQQQAALQQQQQQQQ
  326-  344 (32.14/ 6.78)	GQQVQTPQSMPPPPQPSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.55|      19|      19|     134|     152|       4
---------------------------------------------------------------------------
  134-  152 (34.20/ 8.33)	QQQQQLQQQQQQQQHLIKL
  155-  173 (34.34/ 8.40)	QNQQQIQQQQQQLQRMAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.52|      43|      47|     516|     562|       5
---------------------------------------------------------------------------
  377-  402 (29.66/ 7.66)	.QSPVTART..........PQNFSVPSPgPLNTPVNP...............
  516-  562 (70.91/36.29)	IRSPVFNHSLYRTFV....PAMTAIHGP.PITAPVVCtrkrKLEEDERQSIP
  565-  606 (58.95/23.76)	LQGEV..ARLDPKFLvnldPSHCSNNG....TVHLIC....KLDDKDLPSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.49|      25|      47|     301|     325|       6
---------------------------------------------------------------------------
  271-  295 (35.89/11.96)	QLKFVRAPMV.VQQPQVqPQVQQPQT
  301-  325 (47.17/18.41)	QTTQMAAPGVQVGQSSL.PMLSSPSP
  347-  364 (33.43/10.56)	Q......PGSQ.PNSNV.SSGPAPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.39|      28|     125|     485|     512|       7
---------------------------------------------------------------------------
  461-  481 (28.46/ 6.93)	........TDPSKRCPL...KTLQ.KCEIALEK
  482-  511 (48.05/16.18)	LknDMAVPTPPPPPVPP...TKQQYLCQPLLDA
  608-  638 (43.88/14.21)	L..ELSVPADYPAQSPLwidRQWQYEANPFLKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18830 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQQQQQALQPQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYAQPQQQLKFVRAPMVVQQPQVQPQVQQPQTAVQTAQTTQMAAPGVQVGQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
182
425










Molecular Recognition Features






MoRF SequenceStartStop




NANANA