<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18829

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTSAYYAAITETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGAEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSNKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLASSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQRISPWDIFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPASTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHISYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSAQRFSHQTLQQTPMIGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQTAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPMNWVGDSMEWSRGGRQGIAP
Length2187
PositionKinase
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.07
Grand average of hydropathy-0.508
Instability index57.05
Isoelectric point6.62
Molecular weight243876.62
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18829
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     165.22|      15|      15|    2054|    2068|       1
---------------------------------------------------------------------------
 2054- 2068 (35.97/14.14)	QQQQQQQQQQQQQQQ
 2079- 2093 (30.21/10.74)	QQQQQQQQYHIRQQQ
 2094- 2108 (31.32/11.40)	QQQILRQQQQQQQQQ
 2109- 2123 (35.97/14.14)	QQQQQQQQQQQQQQQ
 2124- 2138 (31.75/11.65)	QQQHQQQQQQQTAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     742.38|     216|     231|     349|     577|       2
---------------------------------------------------------------------------
  216-  440 (276.08/194.81)	.........GSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISAQSTSTlPTTPAPQPPTSSTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS
  441-  673 (328.94/205.49)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSS
  676-  813 (137.36/75.51)	FEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.87|      76|     233|    1596|    1685|       4
---------------------------------------------------------------------------
 1470- 1554 (107.57/60.60)	QKSMSlLSQQPFLSLVltcLKGQDEQREGLLTSLySQVHQIVNNWRDDQYLDDCKPKQLMheaLKLRLNLVGGmFDTV......QRSTQQ.T
 1603- 1685 (117.30/84.61)	QGSME.ENKRAYMNLV...KKLQKELGERQSDSL.EKVRQLLPLPKQTRDVITCEPQGSL...IDTKGNKIAG.FDSIfkkeglQVSTKQrI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     329.24|      58|      76|    1844|    1906|       5
---------------------------------------------------------------------------
 1759- 1796 (29.02/ 7.30)	.....................PEKKAPEPPktDKPGAAPASTE......E..R.KKKSTK...GKKRSQPA..
 1797- 1847 (50.70/17.36)	TktedygMGPGRSGPY.GV........TVP....PDLLHHANPG...SIS..H.ISYRQSsigLYTQNQP...
 1849- 1906 (107.22/49.51)	P......AGGPRVDPYRPVRLPMQKLPTRP..TYPGVLPTTMTGVM.GLE..P.SSYKTS...VYRQQQPAVP
 1910- 1952 (46.02/16.97)	...................RL.RQQLQAKI..QSQGML..GQSSVH.QMT..PsSSYGLQ...TSQGYTPYVS
 1962- 2008 (60.37/31.98)	P......A.GTMVPP......SYSSQPYQS..THPSTNPTLVDPTR.HLQqrP.SGY.......VHQQAPT..
 2010- 2049 (35.91/11.22)	.........GHGLTSAQ..RFSHQTLQQTP..MIGTMTPLSAQGVQaGVR..S.TS.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     259.47|      83|     153|     874|    1026|       6
---------------------------------------------------------------------------
  924- 1016 (130.46/218.08)	LCivAVLRHYhaCLILNQDQMAqVFEGLCGVVKHG.......MNRSDGSSaerciLAYLYDLYTSCSHLKSKFGELFSDF..CSKVKNTI..YCNVEPSESNMR
 1077- 1170 (129.01/69.41)	LC..AELTGY..CKSLSAEWLG.VLKALCCSSNNGtcgfndlLCNVDVSD.....LSFHDSLATFVAILIARQCLLLEDLirCAAIPSLLnaACSEQDSEPGAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.51|      34|     200|    1233|    1266|       7
---------------------------------------------------------------------------
 1233- 1266 (59.38/31.86)	AELKGS..GFTVTGG.AEELPEEEGGG.G..SGGRRQGGR
 1397- 1426 (28.81/11.49)	....GS..S...SGStASNMPSSNKTK.PvlSSLERSGVW
 1433- 1467 (41.32/19.83)	AKLPTSvqGHVLKAA.GEEL..EKGQHlA..SSSRKERDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      24|    1561|    1574|      13
---------------------------------------------------------------------------
 1561- 1574 (24.50/18.21)	LLEIIISGTV..DMQS
 1585- 1600 (20.20/13.49)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18829 with Med12 domain of Kingdom Metazoa
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