<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18828

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTSAYYAAITETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGAEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSNKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLASSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQRISPWDIFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPASTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHISYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSAQRFSHQTLQQTPMIGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQHQQQQQQQTAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPMNWVGDSMEWSRGGRQGIAP
Length2153
PositionKinase
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.07
Grand average of hydropathy-0.493
Instability index56.32
Isoelectric point6.61
Molecular weight240064.56
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18828
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     294.09|      44|      45|    2017|    2060|       1
---------------------------------------------------------------------------
 1895- 1931 (49.64/15.53)	....TSVY.........RQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVH
 1932- 1978 (59.90/20.16)	QmtpSSSYGLQTSQ...GYTPYVSHVGLQQHTGPADPTRHLQQRPSGYVH
 1979- 2021 (58.19/19.39)	Q...QA.PTYGHGL...TSAQRFSHQTLQQTPMIGTMTPLSAQGVQAGVR
 2022- 2065 (80.76/29.58)	S...TSILPEQQQQ...QQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIR
 2066- 2100 (45.60/13.70)	.....Q...QQQQQilrQQQQQQQQQQQQQQQQQQHQQQQQQQ.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.58|      46|     338|    1767|    1814|       2
---------------------------------------------------------------------------
 1767- 1812 (64.23/41.04)	..........P...KTDKPGAApASTEERKKKSTKGKKRSQPATKTEDYGMGPgRSGPY
 1813- 1858 (64.69/32.79)	GV.....tvpPdllHHANPGS..ISHISYRQSSIGLYTQNQPLPA....G.GP.RVDPY
 1860- 1890 (29.66/10.64)	PVrlpmqklpT...RPTYPGVL...................PTTMTGVMGLEP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.90|      42|     338|     660|     704|       3
---------------------------------------------------------------------------
  586-  634 (61.09/28.69)	SESERVEFFNLVlLFCELIRHDvFShnMYTCTLISRGDlafGAPGPRPP
  663-  704 (79.81/43.37)	SESMDIDPSSSV.LFEDMEKPD.FS..LFSPTMPCEGK...GSPSPEKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      14|     663|     122|     135|       4
---------------------------------------------------------------------------
  122-  135 (24.94/15.38)	GTKPLTQLAKKVPI
  786-  799 (25.11/15.55)	GTAETDQLAPIVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     325.75|     108|     663|     837|     972|       5
---------------------------------------------------------------------------
  837-  958 (151.59/154.42)	SHYDQ..HQVTAQVSRNVLEQITSFALGMSYhLPlvqhvQFIFDLME....YSLSISGL.IDFAIQLLNELSVVEAELL.....LKSSDLVGSYTtslCLCivAVLRHYhaCLILNQDQMAqVFEGLCGVVKHG
  987- 1106 (174.16/116.60)	SKFGElfSDFCSKVKNTIYCNVEPSESNMRW.AP.....EFMIDTLEnpaaHTFTYTGLgKSLSENPANRYSFVCNALMhvcvgHHDPDRVNDIA...ILC..AELTGY..CKSLSAEWLG.VLKALCCSSNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     240.33|      73|     143|    1126|    1207|       6
---------------------------------------------------------------------------
 1126- 1207 (109.97/89.89)	DSLATFVAILIARQCLLLEdliRCaaIPSLLNAACSEQDSEPGARLTCRiLLHLFKTPQLNPCQSDGNKPTvgiRSSCDRHL
 1276- 1348 (130.36/80.14)	DVYAKYVLRSICQQEWVGE...RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICYPHRLLDNEDGENPQ...RQRIKRIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18828 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPASTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHISYRQSSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVM
2) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
3) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSV
4) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVN
5) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQG
6) QQQQQQQQQQHQQQQQQQTAPPQPQPQSQPQVAAGLQPQAQGQLPRLGTQPMNWVGDSMEWSRGGRQGIAP
7) TPYVSHVGLQQHTGPADPTRHLQQRPSGYVHQQAPTYGHGLTSAQRFSHQTLQQTPMIGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
1736
687
627
15
1888
2083
1948
1886
726
674
63
1946
2153
2061










Molecular Recognition Features






MoRF SequenceStartStop




1) EERKKK
2) MAAFGI
1780
1
1785
6