<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18821

Description Mediator complex subunit 23
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKCIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNESDIITHFVQSSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVEPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERKFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGNEVGNALLNVVLKSQPLVPRENITSWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVNSGSPASQANQVDTLT
Length1315
PositionTail
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.10
Grand average of hydropathy-0.020
Instability index46.45
Isoelectric point6.91
Molecular weight150434.97
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18821
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     522.51|     193|     562|     207|     554|       1
---------------------------------------------------------------------------
  159-  380 (294.40/387.32)	QLLAAREVIAY...ILERNACLLpAYFAVTE......IRKLYPEGKLPH.W.LLGnlvsDF...VDTFRPTARI...................NSICGRCSLLPVVNNSGAICnSWKLDPAT....LRFpLKgLLPYDKD...LFEPQTALLRYvLEQP....YS................RDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAmeRSETEEKFDDGGTSQLLWQHL.....SSQLIF.FVLFQFASFPHmvlslhqkcipvpdinkpQSTHAFAMTCI
  501-  620 (51.69/63.86)	KLAHAKSSVALapaLVETYSRLL.VYMEIESlgikgfISQLLPTVFKSHaWgILHtlleMFsyrMHHIQPHYRVqllshlhtlaavaqtnqnqLHLCVESTALRLITALG....SSEVQPQF....TRF...............................................................................................................................................................
  899- 1061 (176.42/79.73)	..................................................................................................QSPYLPI..YFGNVC..LRFLPVFdiviHRF.LE.LLPVSKSletLLDHLGGLYKF.HDRPvtylYNtlhyyemhlrerkflkRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNA..REENPWVPDDTYYCRLIGRLVdtmagKSPGPFpNCDWRFNEFPN..................PAAHALHVTCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.26|      35|     300|     798|     835|       3
---------------------------------------------------------------------------
  798-  835 (58.17/44.99)	IEILNDMVWkynIVTLDRLILCLAMRSHEGNEAQVCY.F
 1104- 1139 (59.10/37.17)	ITALPEPYW...IVLHDRIVSVISSPSLTSETEWVGYpF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.28|      50|     662|      22|      89|       4
---------------------------------------------------------------------------
   29-   89 (79.08/82.74)	TPEDEKTKLISCL.GAFRQF........................WGGLSQESheqciQWIVKFIhgQHSPKrisfLYDCL..AMAVET
  675-  751 (75.19/38.48)	TPHNWASHTLSCFpGPLQAFfkqnnvpqesrfnlkknveeeyrkWKSMSNES.....DIITHFV..QSSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.58|      26|     372|     864|     893|       6
---------------------------------------------------------------------------
  864-  893 (47.53/37.03)	LQNDWHTKHMNY.........HKKYpeklYFEG..LAEQVE
 1230- 1266 (39.05/21.45)	LNVDQCSTHLNYmdpicdflyHMKY....MFTGdsVKEQVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18821 with Med23 domain of Kingdom Metazoa
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