<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18820

Description Mediator complex subunit 23
SequenceMETQLQSIFEEVVVSASNCRMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQVLYYHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKIRKARRQGQTWRTLYGHVPVLRSLDFLLECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNESDIITHFVQSSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVEPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRERKFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNAMNAREENPWVPDDTYYCRLIGRLFPNPAAHALHVTCVELMALAVSGNEVGNALLNVVLKSQPLVPRENITSWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAVNSGSPASQANQVPVSLPVTQ
Length1327
PositionTail
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.10
Grand average of hydropathy-0.007
Instability index46.76
Isoelectric point7.95
Molecular weight152009.02
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18820
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.51|      18|      18|     253|     270|       1
---------------------------------------------------------------------------
  253-  270 (32.82/19.72)	PYDKDLFEPQTALLRYVL
  273-  290 (31.70/18.80)	PYSRDMVCNMLGLNKQVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.46|      18|      18|    1011|    1028|       2
---------------------------------------------------------------------------
 1011- 1028 (34.59/26.08)	IGSLKDNRPQG.WCLSDTY
 1029- 1047 (28.87/20.32)	LKNAMNAREENpWVPDDTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.00|      15|      20|     959|     978|       3
---------------------------------------------------------------------------
  959-  978 (18.08/22.64)	PVSKSLETLldHlggLYKFH
  981-  995 (30.92/17.39)	PVTYLYNTL..H...YYEMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.04|      30|     597|     677|     706|       4
---------------------------------------------------------------------------
  677-  706 (56.94/40.93)	HVTDFFTG...SDSIQGTWC..KDILQTIMSFTPH
 1259- 1293 (44.10/29.92)	HMKYMFTGdsvKEQVEKIICnlKPALKLRLRFITH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.40|      19|      20|    1145|    1163|       5
---------------------------------------------------------------------------
 1145- 1163 (36.50/22.00)	YPFRLFDFTACHQSYSEMS
 1166- 1184 (33.90/19.90)	YTLALAHAVWHHSSIGQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.75|      15|      21|     385|     399|       7
---------------------------------------------------------------------------
  385-  399 (28.46/18.02)	FLLECIPVPDINKPQ
  404-  418 (29.29/18.77)	FAMTCIWIHLNRKAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.28|      16|      21|     912|     927|       9
---------------------------------------------------------------------------
  912-  927 (27.69/18.84)	LYFEGLAEQVEPPVQI
  934-  949 (29.58/20.70)	IYFGNVCLRFLPVFDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.51|      10|      23|     748|     758|      10
---------------------------------------------------------------------------
  748-  758 (15.88/14.50)	WKsMSNESDII
  774-  783 (20.63/13.22)	WK.MLLETDHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.67|      13|      21|     874|     886|      11
---------------------------------------------------------------------------
  874-  886 (22.12/14.31)	NDFRNRVSDFVKE
  895-  907 (26.55/18.76)	NDWHTKHMNYHKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18820 with Med23 domain of Kingdom Metazoa
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