<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18810

Description Uncharacterized protein
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQPTDPNLEWTQISTRYLREQLAKISDFYHMASNMGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANNSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKEREEARHQLKKITKDILKILNKKSTTETGVGDEGQKSRKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNDDFTMRGLRRDGNADDIWTAAQNSKACGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMSLFNPSGIGSADASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTAADEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQHQQQRLLRQAQSRPFQQGQPGDQAALFAAQVRPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTAQQQAGSVVLSPSYNSRAYSATHSNPALMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGAGIDAVLTSAHPNLPSVSLPQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTSYGHPSHF
Length2141
PositionKinase
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.07
Grand average of hydropathy-0.422
Instability index57.68
Isoelectric point7.98
Molecular weight239518.23
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18810
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     659.65|     143|     151|    1814|    1958|       1
---------------------------------------------------------------------------
 1713- 1813 (148.11/77.03)	.YHTHPMPKPRSYYLEPLPLPPEEEEEEPTSpvSQEPERKSAELSD......QGKTAA.........................DEEKKTKGRKRKTK....................SSSRVDEYPQ.SNIYRVPPNYSPISSQMMHHPQSTLW
 1814- 1958 (250.90/143.80)	GYNLVGQPQQPGFFLQNQSLAPGGSRLDPTG..SFVPTNTKQALSNML....QRRSGAMMQ..PPSLHAITSQQQLIQMKLLQQHQQQRLLRQAQSRPFqQGqPGDQAALFAAQVR.PSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTAQQQ
 1959- 2061 (145.62/75.59)	AGSVVLSPSY.............NSR.......AYSATHSNPALMERLrqiqQQPSGYVQQqaSPYLQPLTGSQRL.........NHQAL....QQSPL.VG.AGIDAVLTSAHPNlPSVSLPQDP.............MRPRQ.P..QVRQQQ
 2065- 2136 (115.01/57.85)	QMQQPQQPPQPQQSSQPQS.........................................Q..TLGLQAMQPQQPLFPRQGLQQTQQQQ.................QTA...ALVR....QLQKQLSSNQPQ...QGVTSYG............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.23|      34|      43|     882|     916|       2
---------------------------------------------------------------------------
  882-  916 (57.35/34.83)	CIVAVL.RRYHSCLILNPdQTAQVFEGLCGVVKHVV
  927-  961 (54.88/29.21)	CILAYLyDLYVSCSHLRS.KFGDLFSSACSKVKQTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     146.31|      62|     203|    1352|    1423|       4
---------------------------------------------------------------------------
 1184- 1222 (35.58/16.10)	MMLGDAKIGSNNVSSLKNDD...FTMRGLRRdGnaddIWTAA....................................................................................................................................................................
 1352- 1379 (26.18/ 8.17)	..........................................qnskacgksisietanlreyaryvlrticqqewvgehclkeperlctdkelildpvlsnmqaqkllqlicyphgikectegdnlqrqhikrilqnleqwtlrqswlelqlmikqclkdpgsgsvaemnnLLDNIAKATIEVFQQSADLNNNS.......SNSGM
 1380- 1460 (84.54/74.46)	SLFNPSGIGSADASSTRQNGiktFLSSSERR.G....VWLVA........................................................................................................................pliarlptsVQGRVLKAAGEELEKGQHLGSSSkkerdrqKQKSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.70|      34|     203|    1043|    1078|       5
---------------------------------------------------------------------------
 1043- 1078 (57.03/34.55)	TVLSSEWLG..VLKA...LCCSSNHVwgFNDVLCTVDVSDL
 1249- 1287 (50.67/24.23)	TICQQEWVGehCLKEperLCTDKELI..LDPVLSNMQAQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.44|      15|     203|    1304|    1318|       8
---------------------------------------------------------------------------
 1304- 1318 (27.14/15.76)	DNLQ.RQHIKRILQ...NL
 1490- 1501 (16.63/ 6.72)	..LQ.NQ.VNQILS...NW
 1508- 1526 (16.68/ 6.77)	DDIKaRQMMHEALQlrlNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.04|      19|     609|     376|     395|       9
---------------------------------------------------------------------------
  376-  395 (34.07/25.48)	PSALVWNYS.....TNDNkSANPGS
  986- 1009 (29.97/17.12)	PSARSINYSmlgkiLSDN.AANRYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18810 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQQQAGSVVLSPSYNSRAYSATHSNPALMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGAGIDAVL
2) PGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPSLHA
3) QQRLLRQAQSRPFQQGQPGDQAALFAAQVRPSPQLPQYPGLQQAQTMPQGYTMYGTQMPL
4) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTAADEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
5) SAHPNLPSVSLPQDPMRPRQPQVRQQQRLLQMQQPQQPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTSYGHPSHF
1955
1824
1892
1722
2035
2033
1874
1951
1806
2141










Molecular Recognition Features






MoRF SequenceStartStop




NANANA