<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18785

Description Mediator of RNA polymerase II transcription subunit 13
SequenceTMSSSVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPSFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPVNKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISRCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSTSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNTDNTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSSGLCEEEIADKVASWDFVEATQKTNCSCLRHKNLKPRNAGQQGQAASLGQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRISVNDDVGMDTDSASQRLVIAAPDSQVRFSNIRTNDVAKTPQMHGTEMSNSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHLYHQMPTPDPLIPSKPMEDRIDSMSQSFPPQFQDAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREPGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLPSGPAMPFIKDGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLPDDLILLLQDQCTNLFSPFGAADQDPFPKSGVINNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLAAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQSLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLAPAASSTMTMTSGVAVSTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMSSNAAGSMSTQASTVQNGQMGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMVIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2172
PositionMiddle
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.08
Grand average of hydropathy-0.407
Instability index53.09
Isoelectric point5.40
Molecular weight239244.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18785
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.17|      39|      62|     463|     503|       1
---------------------------------------------------------------------------
  463-  503 (65.80/45.05)	EKSEKPQKRPLTPfhHRISVNDDVGMDTDSA..SQRLV..IAAPD
  526-  568 (68.37/40.02)	EMSNSPQPPPLSP..HPCDVVDEGVTKTPSTpqSQHLYhqMPTPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.20|      15|      32|     929|     945|       2
---------------------------------------------------------------------------
  929-  945 (25.20/20.52)	LPPIK......LPEEciYRQSWT
  958-  978 (24.01/11.70)	MPFIKdgdgsnMDQE..YGPAYT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     266.92|      57|      69|     766|     822|       3
---------------------------------------------------------------------------
  718-  751 (24.14/ 8.27)	.......................NSERE...PG...............KKhKVEDGTSSVTvlSHE.EDAMSLFSP
  766-  822 (95.22/58.58)	PPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPG...............SK.KSANGSDDKA..SCK.ESKTGNLDP
  838-  892 (85.42/51.65)	PPS...LEQHIMGFSPMNMNNKEYGSMDTTPGG...............TV.LEGNSSSIGA..QFKiEVDEGFCSP
 1480- 1544 (62.14/35.17)	PTSQSLITPPQM....TNTGNA.NTPSATLAPAasstmtmtsgvavstSV.ATANSTLTTA..STS.SSSSSNL..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.71|      67|     712|     286|     360|       4
---------------------------------------------------------------------------
  286-  360 (108.62/57.96)	PQSDIPTPSSVGSSHCSTSCLGVHQVPASTRDPamssvTLTPPTSPEEVQtvDPQSAQKWVKFSSvSDGFNTDNT
  979- 1045 (125.09/52.27)	PQTHTSFGMPPSSAPPSNGGAGILPSPSTPRFP.....TPRTPRTPRGAG..GPASAQGSVKYEN.SDLYSPAST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     257.23|      78|     326|    1615|    1697|       5
---------------------------------------------------------------------------
 1615- 1697 (135.23/86.99)	MDRDKVGIPTDGD.SHAVTYPPAIVVYIID.PFTYENKDESTNSSNVWTLGL.LRCFLEMVQTLPPHIkstvsVQIIPCQYLLQPV
 1942- 2022 (122.00/69.65)	MQTSQLNTPQDTScTHILVFPTSASVQVASaTYTTENLDLAFNPNNDGADGMvIFDLLDTGDDLDPDI.....INILPASPTGSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.79|      17|     326|    1255|    1285|       9
---------------------------------------------------------------------------
 1255- 1271 (32.03/34.52)	KSSCLHPWSKRNDVSMQ
 1293- 1309 (32.76/ 8.90)	KKRTVRPWGVQGPLTWQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18785 with Med13 domain of Kingdom Metazoa
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