<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP18783

Description Mediator of RNA polymerase II transcription subunit 16
SequenceRPAAGGMMDLAYVCEWEKWPKSTHCPSVPLACAWSCRNLIAFTTDLRSDDQGAGLLPGPWTVHPSVEGLRCHLLPTGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDPNRKDKFPAITHLKFLARDMSEQVSLLCQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAIKRPRTAGPAVHFKAMQLSWTSLALVGIDNYGKLSMLRISPSMGHTLDVNLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQNAALQQVLSTRILAMKASLCRLSPCTVARVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGVLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPTLPGSATSLQLDGLIRAPGQPRIDHLRRLHLGAYPTEECKACARCGCVTMLKSPNRTTAVKQWEQRWIKNC
Length809
PositionTail
OrganismPropithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi coquereli)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Strepsirrhini> Lemuriformes> Indriidae> Propithecus.
Aromaticity0.07
Grand average of hydropathy0.067
Instability index45.98
Isoelectric point8.44
Molecular weight89123.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP18783
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.04|      19|     182|     540|     559|       1
---------------------------------------------------------------------------
  540-  559 (32.02/26.47)	STL..KSLLRPHFLNTPdKSPG
  722-  742 (32.03/20.73)	SRLqpKQPLRLHFGKAP.TLPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     529.17|     112|     298|     118|     229|       2
---------------------------------------------------------------------------
   17-  112 (95.76/49.48)	.......................EKW...PKSTH.....CPSV..PLA..CAWSCR......NLIAFTTdlrSDDQGAGL.LPGPWTV.............HPSVEGLrCH..L..........LPTGSRLLSADADGqikcwsmadhlanSWESSVGSLVEG
  118-  229 (181.92/100.34)	LSWLHNGVKLALHVEKSGASSFGEKF...SRVKF.....SPSL..TLF..GGKPME......GWIAVTV...SGLVTVSL.LKPSGQV.............LTSTESL.CR..LRGRVALADIAFTGGGNIVVATADG.............SSASPVQFYKVC
  236-  359 (117.89/62.54)	KCRIDTEILPSLFMRCTTDPNRKDKFpaiTHLKFlardmSEQV..SLLcqTSSIVE......CW.SLRK...EGLPVNNI.FQQISPVvgdkqpmilkwriLSATNDL.DR..VSA.VALPKLP......ISLTNTDL.............KVASDTQFY...
  418-  527 (133.60/71.82)	LSW....TSLAL....VGIDNYG.KL...SMLRI.....SPSMghTLD..VNLALRhllfllEYCMVTG...YDWWDILLhVQPS.MV.............QSLVEKL.HEeyTRQNAALQQVLST...RILAMKASL.............CRLSPCTVARVC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP18783 with Med16 domain of Kingdom Metazoa
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